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Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases 被引量:2
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作者 Navatha Shree Polavaram samikshan dutta +12 位作者 Ridwan Islam Arup K.Bag Sohini Roy David Poitz Jeffrey Karnes Lorenz C.Hofbauer Manish Kohli Brian A.Costello Raffael Jimenez Surinder K.Batra Benjamin A.Teply Michael H.Muders Kaustubh Datta 《Bone Research》 SCIE CAS CSCD 2021年第2期233-247,共15页
Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone met... Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone metastasis.We observed a significant upregulation of NRP2 in prostate cancer cells metastasized to bone.Here,we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating NRP2 as a promising therapeutic target.Since,osteoclasts present in the tumor microenvironment express NRP2,we have investigated the potential effect of targeting NRP2 in osteoclasts.Our results revealed NRP2 negatively regulates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone lesions.Our study further delineated the molecular mechanisms by which NRP2 regulates osteoclast function.Interestingly,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the bone.These results therefore indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis. 展开更多
关键词 METASTASIS CHEMOTHERAPY treatment
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Deubiquitination in prostate cancer progression:role of USP22 被引量:2
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作者 Nivedita Nag samikshan dutta 《Journal of Cancer Metastasis and Treatment》 CAS 2020年第1期155-167,共13页
Prostate cancer(PCa)is the leading cause of cancer death in men.With more therapeutic modalities available,the overall survival in PCa has increased significantly in recent years.Patients with relapses after advanced ... Prostate cancer(PCa)is the leading cause of cancer death in men.With more therapeutic modalities available,the overall survival in PCa has increased significantly in recent years.Patients with relapses after advanced secondgeneration anti-androgen therapy however,often show poor disease prognosis.This group of patients often die from cancer-related complicacies.Multiple approaches have been taken to understand disease recurrence and to correlate the gene expression profile.In one such study,an 11-gene signature was identified to be associated with PCa recurrence and poor survival.Amongst them,a specific deubiquitinase called ubiquitin-specific peptidase 22(USP22)was selectively and progressively overexpressed with PCa progression.Subsequently,it was shown to regulate androgen receptors and Myc,the two most important regulators of PCa progression.Furthermore,USP22 has been shown to be associated with the development of therapy resistant PCa.Inhibiting USP22 was also found to be therapeutically advantageous,especially in clinically challenging and advanced PCa.This review provides an update of USP22 related functions and challenges associated with PCa research and explains why targeting this axis is beneficial for PCa relapse cases. 展开更多
关键词 USP22 prostate cancer SAGA Deubiquitin
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