An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacter...An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.展开更多
An efficient and facile synthesis of a library of hitherto novel 1,2,3-triazolyl-N-acetyl/N-propionylpyrazoline hybrids （16 examples） in excellent yields （90%-96%） has been accomplished from easily accessible 1,2,...An efficient and facile synthesis of a library of hitherto novel 1,2,3-triazolyl-N-acetyl/N-propionylpyrazoline hybrids （16 examples） in excellent yields （90%-96%） has been accomplished from easily accessible 1,2,3-triazolyl chalcone precursors.展开更多
基金the UGC (BSR) and DST-PURSE for financial supportDepartment of Science and Technology, New Delhi, India for funds under the IRHPA program for the purchase of a NMR spectrometer
文摘An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.
基金UGC(BSR)-India for givingfinancial support as JRF&SRF
文摘An efficient and facile synthesis of a library of hitherto novel 1,2,3-triazolyl-N-acetyl/N-propionylpyrazoline hybrids （16 examples） in excellent yields （90%-96%） has been accomplished from easily accessible 1,2,3-triazolyl chalcone precursors.
