Cancer and Germ Cells

Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes witnessed, increased global incidence of cancer, tumors, neoplasm and mortality. Objectives: Altruistic association of contraception [if any], with increasing cancer, tumor was sought after. Methods: In 2012, retrospective analysis of, prevalence of cancer, tumor in 350 patients of 20 - 35 years, 35 - 50 years, >50 years age groups, from data collected by convenient, stratified random sampling, from different geographical locations, between 2002-2012 and its association with presence, absence of contraception, abortion was undertaken;simultaneously, serum estrogen levels obtained from 105 patients, were also analyzed. From 1983-2012 clinical practice, 212 patients treated for different types of neoplasm namely breast cancer, prostate cancer, cancer cervix and benign prostatic hyperplasia were randomly allotted to the above 3 age groups and the data were analyzed for association with contraception status and possible significance. Results: 6 fold increase in cancer incidence was seen in contraceptive users among >50 years with a p value of <0.0005. Contraception was associated with 4 - 7 fold increase in tumor prevalence among >35 - >50 years with a p value of <0.0005. Endogenous estrogen had decreased to ~5-8 pg in 61% of contraceptive users with a p value of <0.0005;after hysterectomy endogenous estrogen values up to ~0.4 pg were seen. Cholesterol deprived diet, due to decreased synthesis of endogenous estrogen:androgen also was associated with 50% increase in tumor, cancer in youth without contraception. Estrogen receptors were positive in well differentiated cancers of breast, associated with reduced levels of endogenous estrogen among contraceptive users, suggesting estrogen receptor positivity could be a compensatory phenomenon;anaplastic tumors did not exhibit estrogen receptor positivity. 10 - 20 fold increase in breast cancer was seen among 20 - >50 years, in contraceptive users with a p value of <0.0005;20 - 30 fold increase in prostate cancer was seen among 35 - >50 years, in contraceptive users with a p value of <0.0005;cancer of the cervix had increased 20 - 40 fold, among 20 - 70 years, in contraceptive users with a p value of <0.0005. Conclusion: Concept is acquired contraception preventing traversal of normal path by germ cells with resultant smashed destruction of germ cells, consequent reduced endogenous estrogen:androgen surveillance, leading to agonizing faults of cellular genomic repertoire, uncontrolled multiplication preceded by no differentiation of cell cycle, metabolism, resulting in soaringly high incidence of cancers including breast, prostate and uterine cervix in both life partners. Increased estrogen receptors:androgen receptors in breast, prostate well differentiated cancers respectively are, probably a compensatory rise, secondary to the sudden artificially acquired contraception resulting in significant reduction of endogenous germ cell hormones in contraceptive users. Contraception reversal with chemotherapy, radiation therapy, surgery achieves arrest of progression of cancer, reduces incidence, prevalence of neoplasm, as a cause-effect phenomenon and not castration or anti estrogen:antiandrogens which will perpetuate, promote neoplastic diseases by decreasing endogenous estrogen:androgen.

Increasing Incidence of Diabetes Mellitus, Systemic Hypertension and Germ Cells with Endogenous Estrogen

Background: Era of contraception, abortions, [20th, 21st centuries] implemented as family welfare schemes, witnessed increased global incidence of Type 2 diabetes mellitus, systemic hypertension. Objectives: Altruistic association of contraception [if any], with increasing diabetes mellitus, systemic hypertension, was sought after. Methods: In 2012, retrospective analysis of, prevalence of diabetes mellitus, systemic hypertension, in 350 patients of 20 - 35 years, 35 - 50 years, >50 years, age groups, data collected by convenient, stratified random sampling, from different geographical locations, between 2003-2012 and its association with presence, absence of contraception, abortion was undertaken;simultaneously, serum estrogen levels obtained from 105 patients, were also analysed. Results: 10 - 45 fold increase in Type 2 diabetes mellitus was seen in contraceptive users of >20 years to >50 years;15 - 50 fold increase in incidence of systemic hypertension was seen in contraceptive users of >20 years to >50 years. Endogenous estrogen was reduced below normal in 75% of contraceptive users, and 25% of contraceptive users had low normal serum estrogen. Cholesterol deprived diet, due to decreased synthesis of endogenous estrogen, androgen also was associated with 50% increase in diabetes mellitus, systemic hypertension. Conclusion: Concept is acquired contraception, abortion status, with smashed fragmentation of germ cells, reduced endogenous estrogen, androgen, results in defaulted genomic repertoire, deranged cell metabolism, increased incidence of diabetes mellitus, systemic hypertension as part of metabolic syndrome. Contraception reversal declined the diseases as a cause and effective phenomenon.

Increasing Prevalence of Osteoporosis, Hypothyroidism and Endogenous Estrogen with Germ Cells

Background: Women were expressing disabling low back aches and weight gain attributing to puerperal sterilization, when contraception implementation as Family Welfare Program was progressing between ~1983 and ~1989. Hence we sought to identify any correlation existing with contraception. Methods: We performed a retrospective analysis of prevalence of osteoporosis and hypothyroid status, in 350 patients of 20-35 years, 35-50 years, >50 years age groups, from data collected by convenient, stratified random sampling of different geographical locations, between 1995-2012. We also analyzed its association with presence or absence of contraception and abortion. Simultaneously, serum estrogen levels obtained from 105 patients were also analyzed. Results: ~15-25 fold increase in osteoporosis was seen in contraceptive users with a p value of 20->50 years age group;we also found a 6 fold increase in hypothyroidism among contraceptive users aged >35 years [p 20 years age group [p 50 years age group [p < 0.025]. Endogenous estrogen was reduced in 61% of people using contraception with a p value of <0.0005. Conclusion: Concept is that contraception prevents traversal of normal path by germ cells, resulting in smashed fragmentation of germ cells, and consequent decreased endogenous estrogen or androgen leading to defaulted genomic repertoire, deranged cell cycle and cell metabolism resulting in metabolic syndrome, with consequent increase in osteoporosis and hypothyroid status.