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Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells 被引量:3
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作者 Indrajit Srivastava santosh k. misra +3 位作者 Fatemeh Ostadhossein Enrique Daza Jasleena Singh Dipanjan Pan 《Nano Research》 SCIE EI CAS CSCD 2017年第10期3269-3284,共16页
Relationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal application. Here, we report the systema... Relationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal application. Here, we report the systematic synthesis of sub-50 nm carbon nanoparticles (CNP) presenting neutral, anionic, and cationic surface functionalities. A subset of CNPs with -10, 20, and 40 nm hydrodynamic sizes were synthesized with neutral surface headgroups. For the first time, the cellular internalization of these CNPs was systematically quantified in various stages of breast cancer cells (early, late, and metastatic), thereby providing a parametric assessment of charge and size effects. Distinct activities were observed when these systems interacted with cancer cells in various stages. Our results indicated that metastatic breast cancer could be targeted by a nanosystem presenting anionic phosphate groups. On the contrary, for patients in late stage of cancer, drugs could be delivered with sulfonate functionalized carbon nano- particles, which have higher probability of intracellular transport. This study will facilitate the better understanding of nanoparticle-biological entity interaction, and the integration of this knowledge with pathophysiology would promote the engineering of nanomedicine with superior likelihoods of crossing the endocytic "barrier" for drug delivery inside cancerous cells. 展开更多
关键词 personalized medicine ENDOCYTOSIS surface charge size carbon nanoparticles
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An anisotropic propagation technique for synthesizing hyperbranched polyvillic gold nanoparticles 被引量:2
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作者 Aaron S. Schwartz-Duval santosh k. misra +3 位作者 Prabuddha Mukhejee Elyse Johnson Alvin S. Acerbo Dipanjan Pan 《Nano Research》 SCIE EI CAS CSCD 2016年第10期2889-2903,共15页
Of late, many synthesis processes have been studied to develop irregular nano-rnorphologies of gold nanostructures for biomedical applications in order to increase the efficacy of nanoparticle theranostics, tune the p... Of late, many synthesis processes have been studied to develop irregular nano-rnorphologies of gold nanostructures for biomedical applications in order to increase the efficacy of nanoparticle theranostics, tune the plasmonic absorbance spectra, and increase the sensitivity of biomolecule detection through surface enhanced Raman spectroscopy. Here we report, a novel, non-seed mediated versatile single pot synthesis method capable of producing hyperbranched gold "nano-polyvilli" with more than 50-90 branching nanowires propagating from a single origin within each structure. The technique was capable of achieving precise tuning of the branch propagation where the branching could be controlled by varying the duration of incubation, temperature, and hydrogen ion concentration. 展开更多
关键词 gold nanoparticles surface enhanced Raman spectroscopy (SERS) ANISOTROPY asymmetric nanocrystallization
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