Background: Psoriasis is often associated with the risk of physical disability, social discomfort and psychological disorders. Objectives: The aim of this study was to investigate the prevalence of depressive symptoma...Background: Psoriasis is often associated with the risk of physical disability, social discomfort and psychological disorders. Objectives: The aim of this study was to investigate the prevalence of depressive symptomatology among Italian patients with psoriasis vulgaris, in order to better evaluate the disease severity in this patient population. Methods: Five thousand Italian patients with psoriasis were mailed the Center for Epidemiological Studies- DepressionScale (CES- D) questionnaire, a 20- item instrument developed to perform epidemiological studies of depressive symptomatology in the general population. Questionnaires with responses to 16 or more items were considered evaluable. Results: We received evaluable questionnaires from 2,391 patients, including 1,528 men (63.9% ) and 863 women (36.1% ). Depressive symptomatology was observed in 1,4822,391 patients (62% overall; females, 63% ; males, 61% ). Men<40 years of age were significantly more likely to report depressive symptoms than were men ≥ 40 years of age (67 vs. 58% , respectively; p= 0.002). Depressive symptomatology was more prevalent in psoriatic patients with only primary or secondary education than in psoriatic patients with higher education (51 vs. 32% , respectively; p<0.02). Conclusion: Our results are consistent with previous studies showing that psoriasis is associated with profound psychological morbidity, in particular with depression in a large number of patients. It is important to consider this association in the overall management of psoriasis.展开更多
Background: Various reports have recently shown the efficacy of narrowband ul traviolet (UV) B phototherapy at 311 nm in the treatment of early stage mycosis fungoides (MF). Objectives: To examine the effectiveness an...Background: Various reports have recently shown the efficacy of narrowband ul traviolet (UV) B phototherapy at 311 nm in the treatment of early stage mycosis fungoides (MF). Objectives: To examine the effectiveness and tolerability of mon ochromatic excimer light (MEL) at 308 nm as a first treatment for early stage MF (stage IA). Methods: Ten lesions from five patients with a clinical and histolo gical diagnosis of MF were treated with repeated applications of MEL until compl ete remission was achieved or up to a maximum of 10 applications, with a cumulat ive dose of 308 nm UVB of between 6 and 12 J cm- 2. All patients were observed every 2 weeks for 2 months, with a 1- year follow-up. Results: At present, al l patients are in complete remission, with no side-effects. Conclusions: Based on these results, MEL can be considered a useful tool in the treatment of early stage MF.展开更多
文摘Background: Psoriasis is often associated with the risk of physical disability, social discomfort and psychological disorders. Objectives: The aim of this study was to investigate the prevalence of depressive symptomatology among Italian patients with psoriasis vulgaris, in order to better evaluate the disease severity in this patient population. Methods: Five thousand Italian patients with psoriasis were mailed the Center for Epidemiological Studies- DepressionScale (CES- D) questionnaire, a 20- item instrument developed to perform epidemiological studies of depressive symptomatology in the general population. Questionnaires with responses to 16 or more items were considered evaluable. Results: We received evaluable questionnaires from 2,391 patients, including 1,528 men (63.9% ) and 863 women (36.1% ). Depressive symptomatology was observed in 1,4822,391 patients (62% overall; females, 63% ; males, 61% ). Men<40 years of age were significantly more likely to report depressive symptoms than were men ≥ 40 years of age (67 vs. 58% , respectively; p= 0.002). Depressive symptomatology was more prevalent in psoriatic patients with only primary or secondary education than in psoriatic patients with higher education (51 vs. 32% , respectively; p<0.02). Conclusion: Our results are consistent with previous studies showing that psoriasis is associated with profound psychological morbidity, in particular with depression in a large number of patients. It is important to consider this association in the overall management of psoriasis.
文摘Background: Various reports have recently shown the efficacy of narrowband ul traviolet (UV) B phototherapy at 311 nm in the treatment of early stage mycosis fungoides (MF). Objectives: To examine the effectiveness and tolerability of mon ochromatic excimer light (MEL) at 308 nm as a first treatment for early stage MF (stage IA). Methods: Ten lesions from five patients with a clinical and histolo gical diagnosis of MF were treated with repeated applications of MEL until compl ete remission was achieved or up to a maximum of 10 applications, with a cumulat ive dose of 308 nm UVB of between 6 and 12 J cm- 2. All patients were observed every 2 weeks for 2 months, with a 1- year follow-up. Results: At present, al l patients are in complete remission, with no side-effects. Conclusions: Based on these results, MEL can be considered a useful tool in the treatment of early stage MF.
