Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent p...Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent publication,CAR is well established as a xenosensor for drugs and energy metabolism with newer implications in the regulation of normal liver physiology and liver regeneration.展开更多
Metabolic(dysfunction)associated fatty liver disease(MAFLD),previously known as non-alcoholic fatty liver disease,is the most common cause of chronic liver disease worldwide.Many risk factors contribute to the pathoge...Metabolic(dysfunction)associated fatty liver disease(MAFLD),previously known as non-alcoholic fatty liver disease,is the most common cause of chronic liver disease worldwide.Many risk factors contribute to the pathogenesis of MAFLD with metabolic dysregulation being the final arbiter of its development and progression.MAFLD poses a substantial economic burden to societies,which based on current trends is expected to increase over time.Numerous studies have addressed various aspects of MAFLD from its risk associations to its economic and social burden and clinical diagnosis and management,as well as the molecular mechanisms linking MAFLD to end-stage liver disease and hepatocellular carcinoma.This review summarizes current understanding of the pathogenesis of MAFLD and related diseases,particularly liver cancer.Potential therapeutic agents for MAFLD and diagnostic biomarkers are discussed.展开更多
基金supported by the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydney,Australia,and the National Health and Medical Research Council of Australia (NHMRC),Australia Program and Investigator Grants (No.AAP2008983,APP1053206,APP1196492)supported by project grants from Cancer Council NSW,Australia (No.APP1145008 to JG and LQ,APP1070076 to CL and LQ),Cancer Institute NSW,Australia grants 15/TRC/1-01 and 2021/ATRG2028,and an NHMRC Program Grant (No.APP1149976 to JG).
文摘Constitutive androstane receptor(CAR)is a nuclear receptor that is encoded by the gene NR113(nuclear receptor subfamily 1 group I member 3)and is almost exclusively expressed in the liver.1 As reported in our recent publication,CAR is well established as a xenosensor for drugs and energy metabolism with newer implications in the regulation of normal liver physiology and liver regeneration.
基金JG is supported by the Robert W.Storr Bequest to the Sydney Medical Foundation,University of Sydneyand National Health and Medical Research Council of Australia(NHMRC)Program and Investigator Grants(AAP2008983,APP1053206,APP1196492)LQ is supported by NSW Cancer Council grants(APP1145008,APP1070076).
文摘Metabolic(dysfunction)associated fatty liver disease(MAFLD),previously known as non-alcoholic fatty liver disease,is the most common cause of chronic liver disease worldwide.Many risk factors contribute to the pathogenesis of MAFLD with metabolic dysregulation being the final arbiter of its development and progression.MAFLD poses a substantial economic burden to societies,which based on current trends is expected to increase over time.Numerous studies have addressed various aspects of MAFLD from its risk associations to its economic and social burden and clinical diagnosis and management,as well as the molecular mechanisms linking MAFLD to end-stage liver disease and hepatocellular carcinoma.This review summarizes current understanding of the pathogenesis of MAFLD and related diseases,particularly liver cancer.Potential therapeutic agents for MAFLD and diagnostic biomarkers are discussed.
