Alpha-mangostin(AMG),a natural xanthone extracted from Garcinia mangostana Linn,has a variety of pharmacological therapeutic effects such as antioxidant activity,antibacterial activity,anticancer,and anti-inflammatory...Alpha-mangostin(AMG),a natural xanthone extracted from Garcinia mangostana Linn,has a variety of pharmacological therapeutic effects such as antioxidant activity,antibacterial activity,anticancer,and anti-inflammatory[1].However,it has poor aqueous-solubility and dissolution,which results in low bioavailability.Solid self-emulsifying drug delivery system(solid-SEDDS),an effective pharmaceutical strategy,offers the potential for enhancing the oral bioavailability of poorly water-soluble drugs[2].Therefore,solid-SEDDS is of interest as a potential method for enhancing the solubility and dissolution of AMG.展开更多
The floating drug delivery system (FDDS) has become increasingly attractive system for gastroretentive dosage forms because it can prolong gastric retention time and improve drug bioavailability (1)Using low density m...The floating drug delivery system (FDDS) has become increasingly attractive system for gastroretentive dosage forms because it can prolong gastric retention time and improve drug bioavailability (1)Using low density material of polypropylene foam powder is one of the interesting approaches for FDDS development. This floating system has initial low density so it can float immediately without lag time.展开更多
During the past few decades floating drug delivery systems(FDDSs)have been developed to prolong gastric retention time and obtain sufficient drug bioavailability[1].To avoid unpredictable time to float due to variable...During the past few decades floating drug delivery systems(FDDSs)have been developed to prolong gastric retention time and obtain sufficient drug bioavailability[1].To avoid unpredictable time to float due to variable pH of the gastric fluid in each subject and food in the stomach[2],sublimation technique is the new interesting approach to prepare noneffervescent FDDSs[3].The objective of the present study was to develop the low-density film coated floating tablets using sublimable substances.展开更多
文摘Alpha-mangostin(AMG),a natural xanthone extracted from Garcinia mangostana Linn,has a variety of pharmacological therapeutic effects such as antioxidant activity,antibacterial activity,anticancer,and anti-inflammatory[1].However,it has poor aqueous-solubility and dissolution,which results in low bioavailability.Solid self-emulsifying drug delivery system(solid-SEDDS),an effective pharmaceutical strategy,offers the potential for enhancing the oral bioavailability of poorly water-soluble drugs[2].Therefore,solid-SEDDS is of interest as a potential method for enhancing the solubility and dissolution of AMG.
文摘The floating drug delivery system (FDDS) has become increasingly attractive system for gastroretentive dosage forms because it can prolong gastric retention time and improve drug bioavailability (1)Using low density material of polypropylene foam powder is one of the interesting approaches for FDDS development. This floating system has initial low density so it can float immediately without lag time.
文摘During the past few decades floating drug delivery systems(FDDSs)have been developed to prolong gastric retention time and obtain sufficient drug bioavailability[1].To avoid unpredictable time to float due to variable pH of the gastric fluid in each subject and food in the stomach[2],sublimation technique is the new interesting approach to prepare noneffervescent FDDSs[3].The objective of the present study was to develop the low-density film coated floating tablets using sublimable substances.
