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注意力缺陷多动症评价个体疾病发生率的旧测试方法是否能为发病机制提供新的信息
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作者 Rupprecht T. schellmoser s. +1 位作者 Wagner M. 王经纬 《世界核心医学期刊文摘(儿科学分册)》 2005年第12期59-60,共2页
Twelve boys with verified diagnosis of severe attention deficit hyperactivity disorder (mean age 9.2± 2.9 years) and 12 control boys were investigated. According to the DSM IV system the patients were positive re... Twelve boys with verified diagnosis of severe attention deficit hyperactivity disorder (mean age 9.2± 2.9 years) and 12 control boys were investigated. According to the DSM IV system the patients were positive regarding all aspects. None of the patients received medication at or around the time of the investigation. The boys were asked to tap a button 128 times in a frequency that felt comfortable to them. The investigation was performed with specially designed software. There was no significant difference in the mean or median intervals between tapping, However, range and spread of the tapping intervals were significantly higher in patients with hyperactivity disorder. The results show that these children perform less rhythmically although they were allowed to choose the tapping frequency themselves. There are many possible reasons for these results, ranging from social to genetic. One of the reasons could be due to changes in the genetically codedmolecular clock. In humans there are only three genes identified that code for molecular clocks (CLOCK, PER2, BMAL1). In these genes as well as in other proteins and enzymes involved in the signaling pathway, mutations and polymorphisms have been described that lead to a decreased rhythm in motor timing. 展开更多
关键词 注意力缺陷 疾病发生率 测试方法 发病机制 时间间隔 社会因素 节律性 自我感觉良好 编码基因 药物治疗
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