Background and Purpose -Using 930 individuals connected in a single pedigree from an isolated population, participants of the Erasmus Rucphen Family (ERF) study, we investigated the heritability of carotid-femoral pul...Background and Purpose -Using 930 individuals connected in a single pedigree from an isolated population, participants of the Erasmus Rucphen Family (ERF) study, we investigated the heritability of carotid-femoral pulse wave velocity (PWV), carotid intima media thickness (IMT), and carotid plaque score. Methods -PWV was measured between the carotid and femoral arteries as an indicator of aortic stiffness. Common carotid IMT and plaque score, quantifying alterations in arterial wall structure, were measured by ultrasonography. Results -All 3 traits were significantly associated with classic cardiovascular risk factors. Age-and gender-adjusted heritability estimates were 0.36 for PWV, 0.41 for carotid IMT, and 0.28 for plaque score. After adjustment for appropriate risk factors, the heritabilities were 0.26, 0.35, and 0.21 for PWV, IMT, and plaque score, respectively. All heritability estimates were statistically significant (P < 0.001). Taking into account different proportions of variance associated with covariates for each trait, genetic factors explained ≈12%of the total variability for each of the pheno types. Conclusions -To our knowledge, this is the first report on the heritabi lity of PWV. The heritability estimates of IMT and plaque score were similar to those in previous reports. We conclude that genetic factors significantly contri bute to arterial structure and function in this isolated population, presenting the opportunity to locate susceptibility genes related to cardiovascular disorde rs.展开更多
Cardiac angiotensin-I converting enzyme(ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hyp...Cardiac angiotensin-I converting enzyme(ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. We investigated 4264 normotensive and 2174 hypertensive participants of the Rotterdam Study, a population based prospective cohort study. All subjects were available for followup from 1990 until 2000. Incidence rates(IR) of heart failure in normotensive subjects were the same over all genotype strata(10 per 1000 person-years). In hypertensive subjects, the IR increased with the number of D-alleles present (II:IR=13, ID: IR=18 and DD:IR=20 per 1000 person-years). Hypertensive subjects carrying the II-genotype did not have an increased risk of heart failure compared to normotensive II subjects. However, hypertensive subjects carrying one or two copies of the D-allele did have a significantly increased risk of heart failure(ID: RR: 1.4(1.1-1.9) and DD: RR: 1.5 (1.2-2.1)). Our findings suggest that the ACE I/D polymorphism may play a modifying role in the development of heart failure in hypertensive subjects.展开更多
文摘Background and Purpose -Using 930 individuals connected in a single pedigree from an isolated population, participants of the Erasmus Rucphen Family (ERF) study, we investigated the heritability of carotid-femoral pulse wave velocity (PWV), carotid intima media thickness (IMT), and carotid plaque score. Methods -PWV was measured between the carotid and femoral arteries as an indicator of aortic stiffness. Common carotid IMT and plaque score, quantifying alterations in arterial wall structure, were measured by ultrasonography. Results -All 3 traits were significantly associated with classic cardiovascular risk factors. Age-and gender-adjusted heritability estimates were 0.36 for PWV, 0.41 for carotid IMT, and 0.28 for plaque score. After adjustment for appropriate risk factors, the heritabilities were 0.26, 0.35, and 0.21 for PWV, IMT, and plaque score, respectively. All heritability estimates were statistically significant (P < 0.001). Taking into account different proportions of variance associated with covariates for each trait, genetic factors explained ≈12%of the total variability for each of the pheno types. Conclusions -To our knowledge, this is the first report on the heritabi lity of PWV. The heritability estimates of IMT and plaque score were similar to those in previous reports. We conclude that genetic factors significantly contri bute to arterial structure and function in this isolated population, presenting the opportunity to locate susceptibility genes related to cardiovascular disorde rs.
文摘Cardiac angiotensin-I converting enzyme(ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. We investigated 4264 normotensive and 2174 hypertensive participants of the Rotterdam Study, a population based prospective cohort study. All subjects were available for followup from 1990 until 2000. Incidence rates(IR) of heart failure in normotensive subjects were the same over all genotype strata(10 per 1000 person-years). In hypertensive subjects, the IR increased with the number of D-alleles present (II:IR=13, ID: IR=18 and DD:IR=20 per 1000 person-years). Hypertensive subjects carrying the II-genotype did not have an increased risk of heart failure compared to normotensive II subjects. However, hypertensive subjects carrying one or two copies of the D-allele did have a significantly increased risk of heart failure(ID: RR: 1.4(1.1-1.9) and DD: RR: 1.5 (1.2-2.1)). Our findings suggest that the ACE I/D polymorphism may play a modifying role in the development of heart failure in hypertensive subjects.
