Objective: To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD). Methods:The authors prospectively follo wed 48,574 men and 77,254 women who provided information o...Objective: To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD). Methods:The authors prospectively follo wed 48,574 men and 77,254 women who provided information on physical activity in 1986 or in early adulthood. During the follow-up, a total of 252(male) and 135 (female) incident PD cases were identified. Results:In men, greater baseline ph ysical activity was associated with a lower PD risk; compared with the lowest qu intile, the multivariate relative risk (RR) of PD for the highest quintile was 0 .7 (95%CI 0.5 to 1.1; p value, test for trend = 0.007), and the inverse associa tion was still present after excluding the first 10 years of follow-up (RR = 0. 5; p value, test for trend = 0.02).Further, strenuous exercise in early adult li fe was also inversely related to PD risk in men: compared with men who regularly exercised ≤2 months/year, those with ≥10 months of strenuous exercise had a 60%lower PD risk (RR = 0.4; p value, test for trend = 0.005). In women, physical activity assessed at baseline was no t related to PD risk, whereas strenuous exercise in early adulthood tended to be inversely related to PD risk later in life(highest vs lowest categories, RR = 0 .5, 95%CI 0.2 to 1.4; pvalue, test for trend = 0.06). Conclusion: This study su ggests either that higher levels of physical activity may lower the risk of Park inson disease (PD) in men or that men predisposed to PD tend to avoid strenuous physical activity in their early adult years.展开更多
文摘Objective: To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD). Methods:The authors prospectively follo wed 48,574 men and 77,254 women who provided information on physical activity in 1986 or in early adulthood. During the follow-up, a total of 252(male) and 135 (female) incident PD cases were identified. Results:In men, greater baseline ph ysical activity was associated with a lower PD risk; compared with the lowest qu intile, the multivariate relative risk (RR) of PD for the highest quintile was 0 .7 (95%CI 0.5 to 1.1; p value, test for trend = 0.007), and the inverse associa tion was still present after excluding the first 10 years of follow-up (RR = 0. 5; p value, test for trend = 0.02).Further, strenuous exercise in early adult li fe was also inversely related to PD risk in men: compared with men who regularly exercised ≤2 months/year, those with ≥10 months of strenuous exercise had a 60%lower PD risk (RR = 0.4; p value, test for trend = 0.005). In women, physical activity assessed at baseline was no t related to PD risk, whereas strenuous exercise in early adulthood tended to be inversely related to PD risk later in life(highest vs lowest categories, RR = 0 .5, 95%CI 0.2 to 1.4; pvalue, test for trend = 0.06). Conclusion: This study su ggests either that higher levels of physical activity may lower the risk of Park inson disease (PD) in men or that men predisposed to PD tend to avoid strenuous physical activity in their early adult years.
