Background: Extracorporeal membrane oxygenation (ECM-O)-has become an established treatment for severe respiratory distress in a range of pediatric conditions. This study describes the histopathological features in a ...Background: Extracorporeal membrane oxygenation (ECM-O)-has become an established treatment for severe respiratory distress in a range of pediatric conditions. This study describes the histopathological features in a series of 22 children receiving ECMO therapy in whom open lung biopsy was carried out. Aims: To describe the histopathological features of open lung biopsies in children receiving ECMO therapy. Study design: Retrospective review of clinical material. Subjects: Children receiving ECMO therapy in whom open lung biopsy was carried out. Results: In those investigated in infancy, open lung biopsy allowed a definite diagnosis to be made of the underlying condition in more than 90%of cases. In older children, the histopathological changes were more nonspecific and, although providing useful clinical information, a definitive diagnosis could often not be made. In about a quarter of cases, there are additional pathological features, which may be related to ECMO treatment, such as significant intraalveolar haemorrhage, but ECMO does not in itself impair the diagnostic usefulness of open lung biopsy in these selected patients. Conclusion: Open lung biopsy provides clinically useful information in infants receiving ECMO therapy. The histopathological changes may be complex and represent both the effects of ECMO and progression of the underlying disease.展开更多
Objective: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. Design: Observational study. Setting: Teaching hospital. Patient(s): Healthy women at 10-14 weeks of gestation. Inte...Objective: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. Design: Observational study. Setting: Teaching hospital. Patient(s): Healthy women at 10-14 weeks of gestation. Intervention(s): Surgical termination of pregnancy for nonmedical reasons. Main Outcome Measure(s): Products of conception were blindly examined histologically with regard to the extent of decidual endovascular trophoblast invasion. Result(s): Samples were obtained from 20 nulliparous and 10 parous women. The presence of normal intradecidual endovascular trophoblast invasion was identified with a similar frequency in both groups (P=.28). However, the proportion of decidual vessels with endovascular trophoblast invasion was significantly higher in parous women (60% ) compared with nulliparous women (32% , P < .001). Conclusion(s): Endovascular trophoblast invasion in early pregnancy is more extensive in parous women who already had an uncomplicated pregnancy than in nulliparous women.展开更多
文摘Background: Extracorporeal membrane oxygenation (ECM-O)-has become an established treatment for severe respiratory distress in a range of pediatric conditions. This study describes the histopathological features in a series of 22 children receiving ECMO therapy in whom open lung biopsy was carried out. Aims: To describe the histopathological features of open lung biopsies in children receiving ECMO therapy. Study design: Retrospective review of clinical material. Subjects: Children receiving ECMO therapy in whom open lung biopsy was carried out. Results: In those investigated in infancy, open lung biopsy allowed a definite diagnosis to be made of the underlying condition in more than 90%of cases. In older children, the histopathological changes were more nonspecific and, although providing useful clinical information, a definitive diagnosis could often not be made. In about a quarter of cases, there are additional pathological features, which may be related to ECMO treatment, such as significant intraalveolar haemorrhage, but ECMO does not in itself impair the diagnostic usefulness of open lung biopsy in these selected patients. Conclusion: Open lung biopsy provides clinically useful information in infants receiving ECMO therapy. The histopathological changes may be complex and represent both the effects of ECMO and progression of the underlying disease.
文摘Objective: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. Design: Observational study. Setting: Teaching hospital. Patient(s): Healthy women at 10-14 weeks of gestation. Intervention(s): Surgical termination of pregnancy for nonmedical reasons. Main Outcome Measure(s): Products of conception were blindly examined histologically with regard to the extent of decidual endovascular trophoblast invasion. Result(s): Samples were obtained from 20 nulliparous and 10 parous women. The presence of normal intradecidual endovascular trophoblast invasion was identified with a similar frequency in both groups (P=.28). However, the proportion of decidual vessels with endovascular trophoblast invasion was significantly higher in parous women (60% ) compared with nulliparous women (32% , P < .001). Conclusion(s): Endovascular trophoblast invasion in early pregnancy is more extensive in parous women who already had an uncomplicated pregnancy than in nulliparous women.
