BACKGROUND Pulmonary Langerhans cell histiocytosis(PLCH)is a rare cystic lung disease usually affecting young adults.It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendr...BACKGROUND Pulmonary Langerhans cell histiocytosis(PLCH)is a rare cystic lung disease usually affecting young adults.It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.CASE SUMMARY A 70-year-old male patient presented with chronic cough and sputum.He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years.He had a 60 packs/year smoking history.Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment.Those two nodules were resected by means of right thoracoscopic surgery.Pathological evaluation revealed a squamous cell carcinoma and PLCH.CONCLUSION Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.展开更多
Pleomorphic xanthoastrocytoma (PXA) is usually a low grade astrocytic tumor. However, some cases show significant mitotic activity (5 or more mitosis per 10 High Power Field) and/or necrosis. These tumors are describe...Pleomorphic xanthoastrocytoma (PXA) is usually a low grade astrocytic tumor. However, some cases show significant mitotic activity (5 or more mitosis per 10 High Power Field) and/or necrosis. These tumors are described as pleomorphic xanthoastrocytomas with anaplastic features and display increased risk of recurrence. We aimed to evaluate histopathological, immunohistochemical and molecular features of PXAs with anaplastic features, by reporting three primary cases displaying recurrence. Histopathologically we observed rhabdoid-like monomorphic atypical tumoral cells with increased mitotic activity, vascular endothelial proliferation and necrosis. Immunohistochemically, astrocytic and neuronal components displayed different specific staining properties. In 2 cases p53 was immunopositive. We detected BRAF V600E mutation in 2 cases and p16 mutation in one case, by fluorescence in situ hybridization (FISH) method. Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare tumor. We have presented 3 primary APXA cases displaying all characteristic histopathological features. Two of these cases were immunopositive for p53. Therefore, we think that this marker may not be so useful in differentiating APXA from glioblastoma (GBM). Two of our three cases display BRAF V600E mutation, which is compatible with the literature.展开更多
文摘BACKGROUND Pulmonary Langerhans cell histiocytosis(PLCH)is a rare cystic lung disease usually affecting young adults.It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.CASE SUMMARY A 70-year-old male patient presented with chronic cough and sputum.He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years.He had a 60 packs/year smoking history.Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment.Those two nodules were resected by means of right thoracoscopic surgery.Pathological evaluation revealed a squamous cell carcinoma and PLCH.CONCLUSION Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
文摘Pleomorphic xanthoastrocytoma (PXA) is usually a low grade astrocytic tumor. However, some cases show significant mitotic activity (5 or more mitosis per 10 High Power Field) and/or necrosis. These tumors are described as pleomorphic xanthoastrocytomas with anaplastic features and display increased risk of recurrence. We aimed to evaluate histopathological, immunohistochemical and molecular features of PXAs with anaplastic features, by reporting three primary cases displaying recurrence. Histopathologically we observed rhabdoid-like monomorphic atypical tumoral cells with increased mitotic activity, vascular endothelial proliferation and necrosis. Immunohistochemically, astrocytic and neuronal components displayed different specific staining properties. In 2 cases p53 was immunopositive. We detected BRAF V600E mutation in 2 cases and p16 mutation in one case, by fluorescence in situ hybridization (FISH) method. Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare tumor. We have presented 3 primary APXA cases displaying all characteristic histopathological features. Two of these cases were immunopositive for p53. Therefore, we think that this marker may not be so useful in differentiating APXA from glioblastoma (GBM). Two of our three cases display BRAF V600E mutation, which is compatible with the literature.
