Objectives:To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might in-fluence their postnatal skin maturation. Study design:In 22 preterm infants (GA 23-27 weeks),tran...Objectives:To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might in-fluence their postnatal skin maturation. Study design:In 22 preterm infants (GA 23-27 weeks),transepidermal water loss(TEWL) was determined at postnatal ages (PNA) of 0,3,7,14,and 28 days. At a PNA of 7 days,the infants were randomized to care at either 50%or 75%RH. Results:TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days,TEWL was about twice as high in infants nursed at 75%RH (22 ±2 g/m2 h) than in those nursed at 50%RH(13 ±1 g/m2 h; P < 0.001). Conclusions:The results indicate that the level of RH influences skin barrier development,with more rapid barrier formation in infants nursed at a lower RH.The findings have an impact on strategies for promoting skinbarrier integrity in extremely preterm infants.展开更多
Aim: To study cognitive function at 10 y of age in a cohort of children who re quired neonatal intensive care within the Uppsala Neonatal Follow-up Study. Met hods: 226 children, who were born in 1986-1989 and had req...Aim: To study cognitive function at 10 y of age in a cohort of children who re quired neonatal intensive care within the Uppsala Neonatal Follow-up Study. Met hods: 226 children, who were born in 1986-1989 and had required neonatal intens ive care (NIC) and 72 full-term, healthy control children were enrolled in the study. NIC children were grouped according to gestational age (group I, 23-31 w k; subgroup IA, 23-27 wk; IB 28-31 wk; group II, 32-36 wk; group III, > 36 wk ), with infants with congenital malformation (IWCM) included and excluded from t he main groups. The Kaufman Assessment Battery for Children (K-ABC) was adminis tered and results were analysed in relation to the K-ABC global scales: sequent ial, simultaneous, mental processing composite and achievement. Results: The gre at majority of children had well-developed cognitive function, reaching scores at an average level or above. When groups were compared, full-term children tha t required NIC (group III) showed lower scores than controls on all scales measu red by the K-ABC. Preterm children from all the studied groups (groupsIA, IB, I I) showed poorer performance than controls in the simultaneous processing scale, and group IA scored lower than controls in the achievement scale. The incidence of major cognitive impairment (IQ < 70) was low in NIC children ( < 5%), but c hildren from group IA showed significant higher frequency of impairment in the s imultaneous, mental processing composite and achievement scales. Children from g roup IA presented a high frequency of discrepancy between the K-ABC scales, wit h lower simultaneous and higher sequential scores. Analysis with IWCM excluded f rom the main groups revealed identical results. Conclusion: Most children who ne eded neonatal intensive care had developed well their cognitive function at 10 y of age. The long-term effect of neonatal intensive care on cognitive function was more evident in extremely preterm infants (group IA), especially in tasks in volving simultaneous ways of processing information.展开更多
文摘Objectives:To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might in-fluence their postnatal skin maturation. Study design:In 22 preterm infants (GA 23-27 weeks),transepidermal water loss(TEWL) was determined at postnatal ages (PNA) of 0,3,7,14,and 28 days. At a PNA of 7 days,the infants were randomized to care at either 50%or 75%RH. Results:TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days,TEWL was about twice as high in infants nursed at 75%RH (22 ±2 g/m2 h) than in those nursed at 50%RH(13 ±1 g/m2 h; P < 0.001). Conclusions:The results indicate that the level of RH influences skin barrier development,with more rapid barrier formation in infants nursed at a lower RH.The findings have an impact on strategies for promoting skinbarrier integrity in extremely preterm infants.
文摘Aim: To study cognitive function at 10 y of age in a cohort of children who re quired neonatal intensive care within the Uppsala Neonatal Follow-up Study. Met hods: 226 children, who were born in 1986-1989 and had required neonatal intens ive care (NIC) and 72 full-term, healthy control children were enrolled in the study. NIC children were grouped according to gestational age (group I, 23-31 w k; subgroup IA, 23-27 wk; IB 28-31 wk; group II, 32-36 wk; group III, > 36 wk ), with infants with congenital malformation (IWCM) included and excluded from t he main groups. The Kaufman Assessment Battery for Children (K-ABC) was adminis tered and results were analysed in relation to the K-ABC global scales: sequent ial, simultaneous, mental processing composite and achievement. Results: The gre at majority of children had well-developed cognitive function, reaching scores at an average level or above. When groups were compared, full-term children tha t required NIC (group III) showed lower scores than controls on all scales measu red by the K-ABC. Preterm children from all the studied groups (groupsIA, IB, I I) showed poorer performance than controls in the simultaneous processing scale, and group IA scored lower than controls in the achievement scale. The incidence of major cognitive impairment (IQ < 70) was low in NIC children ( < 5%), but c hildren from group IA showed significant higher frequency of impairment in the s imultaneous, mental processing composite and achievement scales. Children from g roup IA presented a high frequency of discrepancy between the K-ABC scales, wit h lower simultaneous and higher sequential scores. Analysis with IWCM excluded f rom the main groups revealed identical results. Conclusion: Most children who ne eded neonatal intensive care had developed well their cognitive function at 10 y of age. The long-term effect of neonatal intensive care on cognitive function was more evident in extremely preterm infants (group IA), especially in tasks in volving simultaneous ways of processing information.
