Securines A—E,three dimeric diarymethane derivatives(1-3)and two enantiomeric diarymethane derivative monomers(4 and 5),were isolated and characterized from the medicinal plant Securidaca inappendiculata.Compounds 1 ...Securines A—E,three dimeric diarymethane derivatives(1-3)and two enantiomeric diarymethane derivative monomers(4 and 5),were isolated and characterized from the medicinal plant Securidaca inappendiculata.Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers,and compound 3 is a mesomeric diarymethane derivative dimer.Their structures were determined by a combination of spectroscopic data,X-ray crystallography,electronic circular dichroism(ECD)analysis,and computational ECD calculations.Dimeric compounds 1-3 showed moderate antiplasmodial activities with IC50 values of 0.9,1.4,and 1.5μM,respectively.展开更多
Three limonoids cipaferoids A-C （1-3） representing two different scaffolds were isolated from Cipadessa baccifera. Their structures were completely assigned by spectroscopic data, CD exciton chirality method, and X-...Three limonoids cipaferoids A-C （1-3） representing two different scaffolds were isolated from Cipadessa baccifera. Their structures were completely assigned by spectroscopic data, CD exciton chirality method, and X-ray crystallography. Compounds 2 and 3 exhibited moderate antimalarial activity with IC50 values of 9.3±0.1 and 14.7±4.8 μmol·L^-1, respectively.展开更多
基金The National Natural Science Foundation of china(No.21532007)the Druglnnovation Major Project of China(2018ZX09711001-001-005)the Biological Resources Pro-gram,CAS(KFJ-BRP-O08)of China are gratefully acknowledged.
文摘Securines A—E,three dimeric diarymethane derivatives(1-3)and two enantiomeric diarymethane derivative monomers(4 and 5),were isolated and characterized from the medicinal plant Securidaca inappendiculata.Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers,and compound 3 is a mesomeric diarymethane derivative dimer.Their structures were determined by a combination of spectroscopic data,X-ray crystallography,electronic circular dichroism(ECD)analysis,and computational ECD calculations.Dimeric compounds 1-3 showed moderate antiplasmodial activities with IC50 values of 0.9,1.4,and 1.5μM,respectively.
基金This work was financially supported by the National Natural Science Foundation （Nos. 21532007, 81273398, and 81321092） of the People＇s Republic of China.
文摘Three limonoids cipaferoids A-C （1-3） representing two different scaffolds were isolated from Cipadessa baccifera. Their structures were completely assigned by spectroscopic data, CD exciton chirality method, and X-ray crystallography. Compounds 2 and 3 exhibited moderate antimalarial activity with IC50 values of 9.3±0.1 and 14.7±4.8 μmol·L^-1, respectively.
