Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma

AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.

Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

瞄准：尽管位于自体免疫的肝炎(AIH ) 下面的病原的机制仍然保持不清楚，免疫系统被认为为疾病的前进批评。细胞的有免疫力的回答可以在 AIH 被连接到肝细胞损坏。最近，许多注意集中于在有效 T 调停房间的有免疫力的回答的产生在单音的原子房间上表示的 costimulatory 分子的批评功能。与 AIH 从病人在单音的原子房间上表示的 costimulatory 分子的分析可以在 AIH 给我们卓见进肝细胞损坏的病原的机制。方法：单音的原子房间(PBMC ) 与 AIH (34 个盒子) 和健康控制(25 个盒子) 从病人被拿的外部血。渗透的单音的原子房间(LIMC ) 与 AIH (18 个盒子) 从病人被拿的肝，有长期的丙肝(CH-C )(13 个盒子) 的病人和有脂肝(2 个盒子) 的病人。用流动血细胞计数，房间为 costimulatory 分子的表示被分析，例如 CD80， CD86，和 CD152 (CTLA-4 ) 。结果与象到 corticosteroids 的 corticosteroids 管理和反应的 gammaglobulin，组织学的等级，存在或缺席的水平那样的临床的数据相比。结果：CD80+ ， CD86+ 和 CD152+ PBMC 的层次显著地作为与健康控制相比与 AIH 在病人被减少。由对比，那些房间比在有 AIH 的病人的 PBMC 在 LIMC 是显著地更高的。特别，不管疾病活动的度， CD86+ LIMC 的水平与 AIH 在病人显示出显著增加，尽管 CD86+ 房间是很少在 PBMC 在场。CD86+ 房间的层次显著地是在场的在里面在有 AIH 的病人的高频率比在有 CH-C 的病人。而且，有有 CD86+ LIMC 的高水平的 AIH 的病人显示出好回答到 corticosteroids，而有 CD86+ LIMC 的底层的 AIH 的 2 个盒子没反应很好。结论：这些结果建议那 LIMC 过去表示的 costimulatory 分子象 CD80 和 CD86 那样看起来在 AIH 的致病起一个作用。特别，在 LIMC 上表示的 CD86 分子可能为 AIH 的诊断并且为 AIH 上的 corticosteroids 的治疗学的效果的预言是有用的。