Chinese expert consensus on transradial access in percutaneous peripheral interventions

Transradial access(TRA)is a safe and comfortable approach and the preferred access for percutaneous coronary intervention.However,TRA is not widely used for peripheral interventions.Currently,there is a lack of data on patient selection,appropriate medical devices,complication prevention,and TRA adoption.Therefore,the Chinese Society of Interventional Oncology of the China Anti-Cancer Association organized nationwide experts to establish a Working Group of China Expert Consensus on TRA in percutaneous peripheral interventions in 2022,and jointly formulated this consensus to better promote the application of TRA in peripheral interventions to guide clinicians on patient selection,technical recommendations,and physician training.This consensus mainly focuses on the current situation,advantages and limitations of TRA in peripheral interventions,anatomical characteristics of the radial artery,patient selection,technical aspects,prevention and management of complications,radiation dose,and learning curve.A consensus was reached through a literature evaluation and by referring to the opinions of the expert group.

Hyperthermia inhibits hypoxia-induced epithelial-mesenchymal transition in HepG2 hepatocellular carcinoma cells

AIM:To investigate the effect of hyperthermia on hy-poxia-induced epithelial-mesenchymal transition (EMT) in HepG2 hepatocellular carcinoma (HCC) cells, and its mechanism. METHODS:Cells were treated with hyperthermia at 43 ℃ for 0.5 h, followed by incubation under hypoxic or normoxic conditions for 72 h. Cell morphology was observed. Expressions of E-cadherin and vimentin were determined by immunofluorescence assay or Western blot. The protein and mRNA expressions of Snail were also determined by Western blot and reverse transcrip-tion-polymerase chain reaction. Cell migratory capacity was evaluated. RESULTS:Hypoxia induced EMT in HepG2 cells, which was evidenced by morphological, molecular and func-tional changes, including the formation of a spindle shape and the loss of cell contact. The expression of E-cadherin was decreased but the expression of vimentin was increased; also, the migratory capability was increased by 2.2 ± 0.20-fold as compared with normoxia. However, those effects were inhibited by hyperthermia pretreatment. Furthermore, protein synthesis and mRNA expression of Snail in the cells were enhanced by hy-poxia as compared with normoxia, and also significantly inhibited by hyperthermia pretreatment. CONCLUSION:Hyperthermia may inhibit hypoxia-induced EMT in HepG2 HCC cells, and the mechanism may involve inhibition of induced expression of Snail.

Percutaneous stenting of malignant superior vena cava syndrome in a patient with persistent left and absent right superior vena cava

Stent placement is the preferred means of managing malignant obstruction of the superior vena cava(SVC). Persistent left and absent right SVC is a very rare venous anomaly. We here report the case of a 58-year-old man who underwent percutaneous stenting for malignant persistent left and absent right SVC obstruction caused by advancement of adenocarcinoma of the upper lobe of the left lung. The patient became symptom-free one day after endovascular stenting through the right femoral vein. However, he experienced repeated supraventricular tachycardia during the procedure. To our knowledge, this is the first report of stenting for malignant SVC obstruction with this congenital anomaly.

A non-uniform allowance allocation method based on interim state stiffness of machining features for NC programming of structural parts

For thin-walled parts,uniform allowance to each machining surface is allocated by the traditional machining method.Considering the sequence of the adjacent machining features,it may cause poor stiffness for some side walls due to a minor wall thickness,which may cause the deformation of the final formed parts to be large,or deduce machining efficiency for some machining features due to too thick remains.In order to address this issue,a non-uniform allowance allocation method based on interim state stiffness of machining features for the finishing of thin-walled structural parts is proposed in this paper.In this method,the interim state model of machining features is constructed according to the machining sequence of the parts,and the stiffness of the side wall is taken as the evaluation index to allocate reasonable allowance value to the corresponding machining surface to ensure the stiffness requirement of the parts in the machining process.According to the finite element simulation results,the non-uniform allowance allocation method proposed in this paper can effectively improve the stiffness of the parts and reduce the deformation of the parts,when compared with the traditional uniform allowance machining method.

Common trunk of the right accessory renal artery and right inferior phrenic artery originating from the thoracic artery:An unreported variation

Accessory renal arteries(ARAs)are common and usually originate from the abdominal aorta and the renal artery.Inferior phrenic arteries(IPAs)can also arise from the abdominal aorta or its branches.In this paper,we present the first case of a common trunk of the right ARA and right IPA arising from the thoracic artery at the level of T10,which was discovered by multidetector-row computed tomography in pretherapeutic evaluation and clearly confirmed by selective angiography.It is important to recognize this anatomical variation when performing cardiovascular and interventional radiological procedures.

Porphyrin-based metal-organic framework nanocrystals for combination of immune and sonodynamic therapy

Immune therapy based on programmed death-ligand 1(PD-L1)is widely used to treat human tumors.The current strategies to improve immune checkpoint blockade therapy fail in rescuing increased expression of PD-L1 in tumor issues.Here,we for the first time synthesized the metal-organic framework(MOF)nanocrystals of rare-earth element dysprosium(Dy)coordinated with tetrakis(4-carboxyphenyl)porphyrin(TCPP),which show well-defined two-dimensional morphologies.The MOF nanocrystals of Dy-TCPP could apparently reduce PD-L1 expression in tumor cells both in vitro and in vivo,and therefore display effective tumor treatment through immune therapy without any immune checkpoint inhibitor drugs.Considering the sensitivity of TCPP ligand toward ultrasound,the prepared Dy-TCPP can also realize sonodynamic therapy(SDT)besides immune therapy.In addition,the Dy-TCPP nanocrystals can efficiently obtain T_(2)-weight magnetic resonance imaging(MRI)of tumor sites.Our study provides the Dy-TCPP nanocrystals as promising diagnostic MRI-guided platforms for the combined treatment on tumors with SDT and immune therapy.Moreover,this strategy succeeds in reducing the elevated expression of PD-L1 in tumor cells,which might serve as a novel avenue for tumor immunotherapy in future.

Diagnosis,treatment,and potential causative mutations of cryptogenic plastic bronchitis

To the Editor:Plastic bronchitis(PB)is a rare pulmonary disease characterized by the production of branching bronchial casts that fill the airways.It is less common in adults than in children,and occurs after 1%to 4%of Fontan surgeries.[1]

Robust bound states in the continuum in a dual waveguide system

Bound states in the continuum(BICs)provide a fascinating platform to route/manipulate waves with ultralow loss by patterning low-refractive-index materials on a high-refractive-index substrate.Principally,the phase of leaking channels can be manipulated via tuning the structural parameters to achieve destructive interference(i.e.,the BIC condition),surprisingly leading to the total elimination of dissipation to the continuum of the substrate.Despite recent developments in BIC photonics,the BIC conditions can only be satisfied at specified geometric sizes for waveguides that dim their application prospects.Here,we propose a dual waveguide system that support BICs under arbitrary waveguide sizes by solely changing the intervals between the two waveguides.Our calculation results show that robust BICs in such architectures stem from the interaction(destructive interference)between leaking waves from the two waveguides.Furthermore,a cladding layer is introduced to improve the fabrication tolerance and reduce the sensitivity of the low-loss condition on the waveguide intervals of the presented dual waveguide system.The proposed approach offers an intriguing solution to establish a BIC concept and may be helpful to improve the potential of BIC photonic devices and circuits.

Clinical characteristics of pulmonary hypertension in bronchiectasis

作为 bronchiectasis 的复杂并发症，肺的高血压(PH ) 与增加的死亡被联系。然而，血液动力学的特征和肺的动脉的高血压的功效(哼) 在有 bronchiectasis 和 PH 的病人的治疗仍然保持未知。有双边的 bronchiectasis 和并发的 PH 的病人在学习被包括。在基线并且在后续期间的耐心的特征，以及幸存，被分析。这观察研究与 51.5 年的吝啬的年龄在 36 个病人被进行(范围， 1774 年) 。走距离的 6 min 是 300.8 搠睯 吗？？

通过金属有机框架材料产生巯基-烯点击反应促进声动力-饥饿疗法治疗肿瘤

缺氧的肿瘤微环境(TME)限制了声动力疗法(SDT)杀灭癌细胞的效果,而且癌细胞中过量的谷胱甘肽(GSH)进一步加剧了这种疗效限制.同时,癌症饥饿疗法作为一种有前途的临床治疗手段已得到越来越多的认可,但基于葡萄糖氧化酶(GOx)的饥饿疗法的疗效也因缺氧问题而受到限制.甘油醛-3-磷酸脱氢酶(GAPDH)是一种关键的糖酵解酶,可作为缺氧情况下饥饿疗法的靶点.本文提出利用二维金属有机框架(MOF)实现巯基-烯点击反应,达到对肿瘤进行SDT和饥饿疗法联合治疗的目的.实验结果表明,因所制备的MOF材料和癌细胞中硫醇物质发生巯基-烯点击反应,该MOF可以在TME中无氧消耗GSH和GAPDH.进一步的体外和体内实验表明,所制备的MOF材料可以有效地杀死癌细胞.这项研究有望为巯基-烯点击反应在SDT疗法和癌症饥饿疗法的应用中开辟一条前景广阔的道路.

Adaptive dynamic sliding mode control for space manipulator with external disturbance

In this paper,a novel adaptive dynamic sliding mode control(ADSMC)methodology is developed for space manipulator control systems with external disturbance.The proposed ADSMC approach can make the systems stable and accurately track the desired signals in the presence of external disturbances.Firstly,the simplified dynamic model of the manipulator is introduced.Then,the proposed adaptive dynamic sliding mode(ADSM)controller is given,which is proved to be able to guarantee high tracking accuracy via effectively estimating the disturbance boundary.Finally,experimental results show that the dynamic sliding mode controller proposed in this paper can not only track the desired trajectory,but also present strong robustness for external disturbance,meanwhile effectively reduce the chattering phenomenon generated by switching between different sliding mode surfaces.