The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in athero...The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in atherosclerotic lesions,the role adipokines in the atherosclerotic process remains to be elucidated.Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity.Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease.Vascular infl ammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation.Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio.The therapeutic goal concerning vaspin is to fi ght atherosclerosis and related diseases,as well as to maintain vascular health.展开更多
Recently,muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases.Skeletal muscle plays a vital role in coordinating the activity and metabolism of end...Recently,muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases.Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines,especially irisin.Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues.Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defi ned by homeostatic model assessment.Irisin reduces endothelial damage by inhibiting infl ammation and oxidative stress,thus playing a key role in maintaining endothelial cell function.Unsurprisingly,low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis.We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.展开更多
文摘The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers.Although adipokine concentrations have been shown to be increased signifi cantly in atherosclerotic lesions,the role adipokines in the atherosclerotic process remains to be elucidated.Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity.Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease.Vascular infl ammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation.Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio.The therapeutic goal concerning vaspin is to fi ght atherosclerosis and related diseases,as well as to maintain vascular health.
文摘Recently,muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases.Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines,especially irisin.Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues.Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defi ned by homeostatic model assessment.Irisin reduces endothelial damage by inhibiting infl ammation and oxidative stress,thus playing a key role in maintaining endothelial cell function.Unsurprisingly,low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis.We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.
