Invasive fungal diseases(IFD)impact morbidity,mortality,hospital stay and healthcare costs in critically ill patients,constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individua...Invasive fungal diseases(IFD)impact morbidity,mortality,hospital stay and healthcare costs in critically ill patients,constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individuals but become life-threatening in cases of immunodeficiency,young infants,disrupted mucosal barriers or polyantibiotic therapy,highlighting the role of immune surveillance in IFD control.^(2)展开更多
基金This work was supported by the Spanish Ministerio de Economía y Competitividad(SAF-2016-80535-R)co-financed by the European Development Regional Fund“A way to achieve Europe”to F.L.M.V.-d-A.,C.C.,S.C.-L.,I.S.,and E.C.are recipients of fellowships from the Ministerio de Economía y Competitividad(BES-2014-069237+4 种基金BES-2017-082107)the Ministerio de Educación Cultura y Deporte(FPU15/02897)the Fundação para a Ciência e a Tecnologia(SFRH/BD/75738/2011and the European Community Seventh Framework Program(BIOTRACK,FP7/2007/2013229673).
文摘Invasive fungal diseases(IFD)impact morbidity,mortality,hospital stay and healthcare costs in critically ill patients,constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individuals but become life-threatening in cases of immunodeficiency,young infants,disrupted mucosal barriers or polyantibiotic therapy,highlighting the role of immune surveillance in IFD control.^(2)
