期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
特应性皮炎动物模型表皮分化蛋白表达的改变 被引量:5
1
作者 杨军 seung hun lee +4 位作者 黄晓波 Kenneth R.Feingold Peter M.Elias 史月君 蔄茂強 《中国皮肤性病学杂志》 CAS 北大核心 2006年第12期730-733,共4页
目的观察特应性皮炎(AD)除真皮T细胞浸润和皮肤增厚外,是否有表皮细胞的分化和增生异常。方法利用反复外涂半抗原的方法制作AD动物模型。在观察该模型皮肤生理学改变的同时,利用免疫组化的方法对表皮分化蛋白的表达和角质形成细胞的增... 目的观察特应性皮炎(AD)除真皮T细胞浸润和皮肤增厚外,是否有表皮细胞的分化和增生异常。方法利用反复外涂半抗原的方法制作AD动物模型。在观察该模型皮肤生理学改变的同时,利用免疫组化的方法对表皮分化蛋白的表达和角质形成细胞的增生进行观察。结果AD组角质层的水分含量明显降低;皮肤水分丢失量及pH明显增高。与对照组相比,AD组表皮兜甲蛋白(loricrin)的表达明显减少;在角质层,中间丝相关蛋白(Filaggrin)和外皮蛋白(involucrin)的表达强度稍微减低,但表达部位有明显地改变。正常时仅表达在角质层,而在AD组其颗粒层和棘细胞层均有较强的染色。抗增生细胞核抗体染色显示,AD的表皮增生极其活跃。HE染色显示AD的表皮明显增厚。结论利用反复外涂半抗原的方法可成功制作AD动物模型,AD除皮肤生理的异常外,还伴有表皮增生和分化的异常。 展开更多
关键词 分化 增生 透过表皮水分丢失 异位性皮炎模型
下载PDF
Self Consistent Calibration of Detectors and Sources for Hard and Soft X-Ray Diagnostics
2
作者 Danilo Pacella Afra Romano +3 位作者 seung hun lee Federica Causa Lori Gabellieri Wonho Choe 《Modern Instrumentation》 2014年第3期13-23,共11页
X-Ray sources, detectors and optical components are now used in a wide range of applications. What is crucial is the absolute calibration of such devices to permit a quantitative assessment of the system under study. ... X-Ray sources, detectors and optical components are now used in a wide range of applications. What is crucial is the absolute calibration of such devices to permit a quantitative assessment of the system under study. A new X-ray laboratory has been built in Frascati (ENEA) to develop diagnostics for nuclear fusion experiments and study applications of these X-ray techniques in other domains, like new material science, non destructive tests and so on. An in-house developed selfconsistent calibration procedure is described that permits the absolute calibration of sources (X-ray emitted fluxes) and detectors (detection efficiencies) as function of the X-ray photon energy, in the range 2 - 120 keV. The calibration procedure involves the use of an in-house developed code that also predicts the spectral response of any detector in any experimental condition that can be setup in the laboratory. The procedure has been then applied for the calibration and characterisation of gas and solid state imaging detectors, such as Medipix-2, GEM gas detector, CCD camera, Cd-Te C-MOS imager, demonstrating the versatility of the method developed here. 展开更多
关键词 X-RAY Detector X-RAY Source ABSOLUTE CALIBRATION Plasma Physics DIAGNOSTICS
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部