The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes

Background:High concentrations of low-density lipoprotein cholesterol(LDL-C)have been a known risk factor for cardiovascular diseases.Also,the role of oxidized LDL(ox-LDL)in forming atherosclerosis plaque has been proven.However,it has not yet been proven that atherogenic LDL-C byproducts like ox-LDL will decrease by keeping the LDL levels at the desired level.This study aimed to examine the relationship between LDL-C and ox-LDL in different LDL-C values in patients with type 2 diabetes(T2D).Methods:In this cross-sectional study,347 patients with T2D who received statins were enrolled.LDL-C values were defined into four groups as LDLC<55 mg/dL,55 mg/dL≤to<70 mg/dL,70 mg/dL≤to<100 mg/dL and LDLC≥100 mg/dL.Total cholesterol,triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and ox-LDL were studied in the four defined groups.Results:Ox-LDL levels were not different among the four groups(p=0.30).In addition,LDL-C and ox-LDL levels had no significant correlation(r=0.480,p=0.376).Additionally,based on this study analysis,ox-LDL levels were significantly correlated with TG levels(r=0.119,p<0.05)and TG/HDL ratio(r=0.390,p<0.01).Conclusions:It is concluded that ox-LDL levels were not associated with different LDL-C level categories from<55 mg/dL to>100 mg/dL in patients with T2D.However,the revealed association of ox-LDL with TG level and TG/HDL ratio may be considered in the clinic.