Objective:To evaluate the protective effects of honey compound syrup on sperm count and testis tissue in rats.Methods:Thirty rats were randomly assigned to five groups.The control group received 1 mL normal saline wit...Objective:To evaluate the protective effects of honey compound syrup on sperm count and testis tissue in rats.Methods:Thirty rats were randomly assigned to five groups.The control group received 1 mL normal saline with dimethyl sulfoxide intraperitoneally;the busulfan group received busulfan 10 mg/kg body weight at the first and twenty-first days of the experiment via intraperitoneal injection;the last three groups received busulfan 10 mg/kg body weight to induce azoospermia,and then received 1.0,1.5,or 2.0 mg/kg honey compound syrup,respectively,after induction of azoospermia.After administration,the testis and epididymis of all rats were removed.Then,reproductive organ weight and sperm parameters(sperm concentration,epididymal sperm reserve and daily sperm production)were measured.After hematoxylin-eosin staining,seminiferous tubule cells and diameters were assessed.Results:Busulfan damaged the testis tissue and impaired spermatogenesis.Administration of honey compound syrup in three doses improved testis tissue and spermatogenesis.The protective effects of honey compound syrup may relate to the antioxidant properties of honey and other compounds in this syrup.Conclusions:Administration of honey compound syrup could be an ameliorative agent for the side effects of chemotherapy drugs such as busulfan on the male reproductive system.展开更多
Asthma is chronic inflammation of the airways characterized by airway hyper-responsiveness,wheezing,cough,and dyspnea.Asthma affects>350 million people worldwide.The Th2 immune response is a major contributor to th...Asthma is chronic inflammation of the airways characterized by airway hyper-responsiveness,wheezing,cough,and dyspnea.Asthma affects>350 million people worldwide.The Th2 immune response is a major contributor to the pathophysiology of asthma.Targeted therapy modulating cell signaling pathways can be a powerful strategy to design new drugs to treat asthma.The potential molecular pathways that can be targeted include IL-4-IL-13-JAK-STAT-MAP kinases,adiponectin-iNOS-NF-κB,PGD2-CRTH2,IFNs-RIG,Wnt/β-catenin-FAM13A,FOXC1-miR-PI3K/AKT,JNK-Gal-7,Nrf2-ROS,Foxp3-RORγt,CysLTR,AMP,Fas-FasL,PTHrP/PPARγ,PAI-1,FcɛRI-LAT-SLP-76,Tim-3-Gal-9,TLRs-MyD88,PAR2,and Keap1/Nrf2/ARE.Therapeutic drugs can be designed to target one or more of these pathways to treat asthma.展开更多
基金This study was supported by Shahid Beheshti University of Medical Sciences(grant number:184)。
文摘Objective:To evaluate the protective effects of honey compound syrup on sperm count and testis tissue in rats.Methods:Thirty rats were randomly assigned to five groups.The control group received 1 mL normal saline with dimethyl sulfoxide intraperitoneally;the busulfan group received busulfan 10 mg/kg body weight at the first and twenty-first days of the experiment via intraperitoneal injection;the last three groups received busulfan 10 mg/kg body weight to induce azoospermia,and then received 1.0,1.5,or 2.0 mg/kg honey compound syrup,respectively,after induction of azoospermia.After administration,the testis and epididymis of all rats were removed.Then,reproductive organ weight and sperm parameters(sperm concentration,epididymal sperm reserve and daily sperm production)were measured.After hematoxylin-eosin staining,seminiferous tubule cells and diameters were assessed.Results:Busulfan damaged the testis tissue and impaired spermatogenesis.Administration of honey compound syrup in three doses improved testis tissue and spermatogenesis.The protective effects of honey compound syrup may relate to the antioxidant properties of honey and other compounds in this syrup.Conclusions:Administration of honey compound syrup could be an ameliorative agent for the side effects of chemotherapy drugs such as busulfan on the male reproductive system.
文摘Asthma is chronic inflammation of the airways characterized by airway hyper-responsiveness,wheezing,cough,and dyspnea.Asthma affects>350 million people worldwide.The Th2 immune response is a major contributor to the pathophysiology of asthma.Targeted therapy modulating cell signaling pathways can be a powerful strategy to design new drugs to treat asthma.The potential molecular pathways that can be targeted include IL-4-IL-13-JAK-STAT-MAP kinases,adiponectin-iNOS-NF-κB,PGD2-CRTH2,IFNs-RIG,Wnt/β-catenin-FAM13A,FOXC1-miR-PI3K/AKT,JNK-Gal-7,Nrf2-ROS,Foxp3-RORγt,CysLTR,AMP,Fas-FasL,PTHrP/PPARγ,PAI-1,FcɛRI-LAT-SLP-76,Tim-3-Gal-9,TLRs-MyD88,PAR2,and Keap1/Nrf2/ARE.Therapeutic drugs can be designed to target one or more of these pathways to treat asthma.
