Objective：It has been reported that the intravenous anesthetic propofol（PPF）has anti-inflammatory effects in vitro and in patients.The purpose of this study was to investigate whether PPF has anti-inflammatory effe...Objective：It has been reported that the intravenous anesthetic propofol（PPF）has anti-inflammatory effects in vitro and in patients.The purpose of this study was to investigate whether PPF has anti-inflammatory effects in lipopolysaccharide（LPS）-induced septic shock by inhibiting the induction of pro-inflammatory cytokinesinterleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）and high mobility group box 1（HMGB1）in rats.Methods：Thirty six male Wistar rats were randomly assigned to one of three groups（control group,PPF＋LPS group and LPS group;n=12 per group）.Control group rats received a 0.9%NaCl solution（NS）by the tail vein.The PPF＋ LPS group rats received PPF（10 mg/kg bolus,followed by infusion at 10 mg/（kg·h）through a femoral vein catheter）1 h before LPS（7.5 mg/kg）administration via the tail vein.The LPS group rats received injection of LPS（7.5 mg/kg）via the tail vein.Hemodynamic effects were recorded as well as mortality rates,and plasma cytokine concentrations（TNF-α,IL-6,HMGB1）were measured for the 24-h observation period.Results：The mean arterial pressure and heart rate of the PPF＋LPS group were more stable than those of the LPS group.The mortality at 24 h after the administration of the LPS injection was much higher in the LPS group（58.3%）compared to the PPF＋ LPS group（25.0%）.Plasma concentrations of cytokines（IL-6 and TNF-α）and HMGB1 were significantly reduced in the PPF＋LPS group compared to the LPS group（P0.05）.Conclusion：Pretreatment with PPF reduced the mortality rate of rats and attenuated the pro-inflammatory cytokine responses in an endotoxin shock model through an anti-inflammatory action inhibiting induction of HMGB1.展开更多
文摘Objective：It has been reported that the intravenous anesthetic propofol（PPF）has anti-inflammatory effects in vitro and in patients.The purpose of this study was to investigate whether PPF has anti-inflammatory effects in lipopolysaccharide（LPS）-induced septic shock by inhibiting the induction of pro-inflammatory cytokinesinterleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）and high mobility group box 1（HMGB1）in rats.Methods：Thirty six male Wistar rats were randomly assigned to one of three groups（control group,PPF＋LPS group and LPS group;n=12 per group）.Control group rats received a 0.9%NaCl solution（NS）by the tail vein.The PPF＋ LPS group rats received PPF（10 mg/kg bolus,followed by infusion at 10 mg/（kg·h）through a femoral vein catheter）1 h before LPS（7.5 mg/kg）administration via the tail vein.The LPS group rats received injection of LPS（7.5 mg/kg）via the tail vein.Hemodynamic effects were recorded as well as mortality rates,and plasma cytokine concentrations（TNF-α,IL-6,HMGB1）were measured for the 24-h observation period.Results：The mean arterial pressure and heart rate of the PPF＋LPS group were more stable than those of the LPS group.The mortality at 24 h after the administration of the LPS injection was much higher in the LPS group（58.3%）compared to the PPF＋ LPS group（25.0%）.Plasma concentrations of cytokines（IL-6 and TNF-α）and HMGB1 were significantly reduced in the PPF＋LPS group compared to the LPS group（P0.05）.Conclusion：Pretreatment with PPF reduced the mortality rate of rats and attenuated the pro-inflammatory cytokine responses in an endotoxin shock model through an anti-inflammatory action inhibiting induction of HMGB1.
