Hydroxycitric acid （HCA） is derived primarily from the Garcinia plant and is widely used for its anti-in- flammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this stu...Hydroxycitric acid （HCA） is derived primarily from the Garcinia plant and is widely used for its anti-in- flammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund＇s Adjuvant （CFA） emulsion containing myelin oligodendrocyte glycoprotein （35-55）. Treatment with HCA at 2 g/kg/d for 3 weeks obviously improved the symptoms of nerve injury of experimental autoimmune encephalomyelitis mice, decreased serum interleulin-6, tumor necrosis factor alpha, nitric oxide, and malondialdehyde levels, and increased superoxide dismutase and glutathione reduc- tase activities. These findings suggest that HCA exhibits neuroprotective effects on multiple sclerosis-caused nerve injury through ameliorating inflammation and oxidative stress.展开更多
基金supported by Vice Chancellor for Research,Alborz University of Medical Sciences,No.1394-01-01-1050
文摘Hydroxycitric acid （HCA） is derived primarily from the Garcinia plant and is widely used for its anti-in- flammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic effects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund＇s Adjuvant （CFA） emulsion containing myelin oligodendrocyte glycoprotein （35-55）. Treatment with HCA at 2 g/kg/d for 3 weeks obviously improved the symptoms of nerve injury of experimental autoimmune encephalomyelitis mice, decreased serum interleulin-6, tumor necrosis factor alpha, nitric oxide, and malondialdehyde levels, and increased superoxide dismutase and glutathione reduc- tase activities. These findings suggest that HCA exhibits neuroprotective effects on multiple sclerosis-caused nerve injury through ameliorating inflammation and oxidative stress.
