Aim:We aimed to study the clinical and pathological characteristics of liver transplant recipients with hepatocellular carcinoma recurrence.Methods:We reviewed the data for 26 patients who had tumor recurrence after d...Aim:We aimed to study the clinical and pathological characteristics of liver transplant recipients with hepatocellular carcinoma recurrence.Methods:We reviewed the data for 26 patients who had tumor recurrence after deceased donor liver transplant for hepatocellular carcinoma at the Johns Hopkins Hospital from January 2005 to December 2015.Results:In total,88%of recipients were males.The mean age was 59 years.On explant,poor differentiation was detected in 43%,while 73%had microvascular invasion.Overall,62%were diagnosed to be outside of Milan criteria.Out of these,15%met the criteria for downstaging.Twenty(77%)patients had pre-transplant alpha fetoprotein levels≥20 ng/mL.In 54%of patients,the location of hepatocellular carcinoma(HCC)recurrence was extrahepatic,followed by intrahepatic in 31%and both intra-and extrahepatic in 15%.The post-transplant tumor recurrence was diagnosed at a mean of 427 days(range 34-1502).Fifty percent of HCC recurrences were diagnosed within one year following liver transplant.Twenty(77%)patients received treatment for their recurrent HCC:external radiation(n=10),surgical resections(n=8;brain 4,spine 2,bone 1,and Whipple surgery 1),sorafenib(n=7),locoregional therapy(n=5).Overall,24 out of 26(92%)recipients died within four years after the transplant.Conclusion:HCC recurrence after liver transplant is infrequent.More than fifty percent of HCC recurrences following liver transplant are extrahepatic.Despite better recipient selection for liver transplant,the curative options are limited in recurrent cases and associated with extremely poor outcomes.展开更多
基金This Research is partially supported by NIH GrantsR44 CA165312-Development of a urine test for the early detection of liver cancer.U01 CA230690-Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer
文摘Aim:We aimed to study the clinical and pathological characteristics of liver transplant recipients with hepatocellular carcinoma recurrence.Methods:We reviewed the data for 26 patients who had tumor recurrence after deceased donor liver transplant for hepatocellular carcinoma at the Johns Hopkins Hospital from January 2005 to December 2015.Results:In total,88%of recipients were males.The mean age was 59 years.On explant,poor differentiation was detected in 43%,while 73%had microvascular invasion.Overall,62%were diagnosed to be outside of Milan criteria.Out of these,15%met the criteria for downstaging.Twenty(77%)patients had pre-transplant alpha fetoprotein levels≥20 ng/mL.In 54%of patients,the location of hepatocellular carcinoma(HCC)recurrence was extrahepatic,followed by intrahepatic in 31%and both intra-and extrahepatic in 15%.The post-transplant tumor recurrence was diagnosed at a mean of 427 days(range 34-1502).Fifty percent of HCC recurrences were diagnosed within one year following liver transplant.Twenty(77%)patients received treatment for their recurrent HCC:external radiation(n=10),surgical resections(n=8;brain 4,spine 2,bone 1,and Whipple surgery 1),sorafenib(n=7),locoregional therapy(n=5).Overall,24 out of 26(92%)recipients died within four years after the transplant.Conclusion:HCC recurrence after liver transplant is infrequent.More than fifty percent of HCC recurrences following liver transplant are extrahepatic.Despite better recipient selection for liver transplant,the curative options are limited in recurrent cases and associated with extremely poor outcomes.
