Congenital syphilis(CS)is a significant public health problem worldwide.The majority of cases of CS are caused by in utero transmission.The World Health Organization launched the global elimination of CS initiative wi...Congenital syphilis(CS)is a significant public health problem worldwide.The majority of cases of CS are caused by in utero transmission.The World Health Organization launched the global elimination of CS initiative with the goal of reducing mother-to-child transmission of syphilis.The risk for CS is mainly related to three factors:(1)high matemal prevalence,(2)low coverage of antenatal care services,and(3)treatment failure.The long-acting penicillin preparations such as benzathine penicillin G are the preferred therapies for maternal syphilis.There are several challenges in preventing CS from both pregnant women and their health care providers.These problems include that prenatal care lack or delay,syphilis management flaws from health care providers,lacks of basic information,and awareness about maternal syphilis and CS by public.Many efforts have been made to solve the problems.These include that dual elimination of mother-to-child transmission(EMTCT)of both human immunodeficiency virus(HIV)and syphilis or triple EMTCT of HIV,syphilis and hepatitis B,World Health Organization country validation of EMTCT of syphilis and HIV,set up a CS case review board and a National Day to combat syphilis and CS.展开更多
Group B streptococcus(GBS)is a leading cause of neonatal infection.Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease(EOD).The obstetric measures ...Group B streptococcus(GBS)is a leading cause of neonatal infection.Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease(EOD).The obstetric measures for effective prevention of GBS EOD include universal prenatal screening by vaginal-rectal culture,correct specimen collection and processing,appropriate implementation of intrapartum antibiotic prophylaxis,and coordination with pediatric care providers.It is now recommended to universal screen GBS between 36^(0/7)and 37^(6/7)weeks of gestation and to identify groups of women who are eligible for intravenous intrapartum antibiotic prophylaxis as a means of preventing GBS EOD.展开更多
基金This research was supported by the Shenzhen Science and Technology Plan(JCYJ20180228162311024)Shenzhen Health System Key Discipline Construction Capacity Enhancement Project(SZXJ201606001)
文摘Congenital syphilis(CS)is a significant public health problem worldwide.The majority of cases of CS are caused by in utero transmission.The World Health Organization launched the global elimination of CS initiative with the goal of reducing mother-to-child transmission of syphilis.The risk for CS is mainly related to three factors:(1)high matemal prevalence,(2)low coverage of antenatal care services,and(3)treatment failure.The long-acting penicillin preparations such as benzathine penicillin G are the preferred therapies for maternal syphilis.There are several challenges in preventing CS from both pregnant women and their health care providers.These problems include that prenatal care lack or delay,syphilis management flaws from health care providers,lacks of basic information,and awareness about maternal syphilis and CS by public.Many efforts have been made to solve the problems.These include that dual elimination of mother-to-child transmission(EMTCT)of both human immunodeficiency virus(HIV)and syphilis or triple EMTCT of HIV,syphilis and hepatitis B,World Health Organization country validation of EMTCT of syphilis and HIV,set up a CS case review board and a National Day to combat syphilis and CS.
基金supported by the Shenzhen Science and Technology Plan(JCYJ20180228162311024)
文摘Group B streptococcus(GBS)is a leading cause of neonatal infection.Maternal vaginal-rectal colonization with GBS during the intrapartum period is a prerequisite for GBS early-onset disease(EOD).The obstetric measures for effective prevention of GBS EOD include universal prenatal screening by vaginal-rectal culture,correct specimen collection and processing,appropriate implementation of intrapartum antibiotic prophylaxis,and coordination with pediatric care providers.It is now recommended to universal screen GBS between 36^(0/7)and 37^(6/7)weeks of gestation and to identify groups of women who are eligible for intravenous intrapartum antibiotic prophylaxis as a means of preventing GBS EOD.
