The antiretroviral action of dC14 in vitro has been proven in previous experiments. This paper deals with the effect of dC14 in vivo.Intraperitoneal inoculation of tumor cells into mice without dC14 treatment induced ...The antiretroviral action of dC14 in vitro has been proven in previous experiments. This paper deals with the effect of dC14 in vivo.Intraperitoneal inoculation of tumor cells into mice without dC14 treatment induced ascitic tumors after a latency of 6 days and death of the mice after 11 days. Both incidence and mortality of disease were 100%. In animals receiving dC14 treatment, the incidence and mortality were less, latency and survival periods were longer. Viral sequences could be detected in tumor cells and in spleens of tumor cell inoculated animals, receiving dC14 treatment or not but could not be detected in normal animals. Studied suggest that the suppressive action of dC14 on the development of mouse SRS ascitic tumor may be through blocking gene expression of virus.展开更多
In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the num...In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the number and strength of theenzyme-substrate interaction. By means of nuclear magnetic resonance(NMR), usingcytidine 2′-, 3′- and 5′-monophosphate(2′-, 3′- and 5′-CMP) as inhibitors,Meadows et al. investigated the base orientation relative to the ribose moiety展开更多
文摘The antiretroviral action of dC14 in vitro has been proven in previous experiments. This paper deals with the effect of dC14 in vivo.Intraperitoneal inoculation of tumor cells into mice without dC14 treatment induced ascitic tumors after a latency of 6 days and death of the mice after 11 days. Both incidence and mortality of disease were 100%. In animals receiving dC14 treatment, the incidence and mortality were less, latency and survival periods were longer. Viral sequences could be detected in tumor cells and in spleens of tumor cell inoculated animals, receiving dC14 treatment or not but could not be detected in normal animals. Studied suggest that the suppressive action of dC14 on the development of mouse SRS ascitic tumor may be through blocking gene expression of virus.
基金Project supported by the National Natural Science Foundation of China.
文摘In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the number and strength of theenzyme-substrate interaction. By means of nuclear magnetic resonance(NMR), usingcytidine 2′-, 3′- and 5′-monophosphate(2′-, 3′- and 5′-CMP) as inhibitors,Meadows et al. investigated the base orientation relative to the ribose moiety
