In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the num...In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the number and strength of theenzyme-substrate interaction. By means of nuclear magnetic resonance(NMR), usingcytidine 2′-, 3′- and 5′-monophosphate(2′-, 3′- and 5′-CMP) as inhibitors,Meadows et al. investigated the base orientation relative to the ribose moiety展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘In enzyme-catalyzed reactions, there is not only a substrate-inducedconformational change in enzyme, but also an enzyme-induced conformational changein substrate.This "induced fit" serves to maximize the number and strength of theenzyme-substrate interaction. By means of nuclear magnetic resonance(NMR), usingcytidine 2′-, 3′- and 5′-monophosphate(2′-, 3′- and 5′-CMP) as inhibitors,Meadows et al. investigated the base orientation relative to the ribose moiety
