Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesi...Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesis and NADPH production,and increased demand for nitrogen sources[1].As an increasing understanding of cancer cell metabolism has been gained in recent years,the metabolic changes and molecular mechanisms associated with tumors in different tumor stages have been gradually revealed.展开更多
Cytosolic isocitrate dehydrogenase 1(IDH1)and its mitochondrial counterpart,IDH2,are critical TCA cycle enzymes that catalyze the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate(a-KG).Mutations ...Cytosolic isocitrate dehydrogenase 1(IDH1)and its mitochondrial counterpart,IDH2,are critical TCA cycle enzymes that catalyze the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate(a-KG).Mutations in IDH1/2 occur in∼80%of grade II-III gliomas and secondary glioblastomas,^(1–3) and in 10%to 20%of acute myeloid leukemia(AML).^(4–6) To date,all identified mutations in IDH1/2 are heterozygous,missense mutations,leading to the substitution of arginine 132 in IDH1 and arginine 172 or 140 in IDH2.展开更多
基金supported by the National Natural Science Foundation of China(81974430)the Natural Science Foundation of Guangdong Province(2019A1515012037)the National Heart,Lung,and Blood Institute,NIH,USA(5R00HL136924-03).
文摘Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesis and NADPH production,and increased demand for nitrogen sources[1].As an increasing understanding of cancer cell metabolism has been gained in recent years,the metabolic changes and molecular mechanisms associated with tumors in different tumor stages have been gradually revealed.
文摘Cytosolic isocitrate dehydrogenase 1(IDH1)and its mitochondrial counterpart,IDH2,are critical TCA cycle enzymes that catalyze the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate(a-KG).Mutations in IDH1/2 occur in∼80%of grade II-III gliomas and secondary glioblastomas,^(1–3) and in 10%to 20%of acute myeloid leukemia(AML).^(4–6) To date,all identified mutations in IDH1/2 are heterozygous,missense mutations,leading to the substitution of arginine 132 in IDH1 and arginine 172 or 140 in IDH2.
