聚天门冬氨酸酯聚脲涂料的发展及应用研究进展

聚天门冬氨酸酯(PAE)聚脲涂料是由氨基酸酯和异氰酸酯制备的弹性材料,具有凝胶时间可控、固含量高、溶剂少、耐腐蚀、绿色环保等特点。因此,它已广泛应用于混凝土防护、防水防腐、胶黏剂、地坪涂料等众多领域,并具有广阔的发展前景。文中综述了PAE聚脲涂料的合成,并详细阐述了其合成原理、优缺点,重点介绍了不同组分和改性方法对产品性能的影响;综述了PAE聚脲涂料在不同领域的应用及应用实例。最后,对其进一步发展和应用进行了展望。

Venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock induced by adrenal lesions:a case report and review of the literature

The adrenal gland secretes a variety of hormones that regulate physiological functions,and adrenal lesions can lead to insidious or sudden onset diseases that are easily misdiagnosed.Recently,several young patients with unknown sudden and refractory cardiogenic shock or cardiac arrest(CA)were successfully treated in our emergency department by the application of venoarterial extracorporeal membrane oxygenation(VA-ECMO).These life-threatening conditions were finally determined to be caused by adrenal lesions,which highlight the bridging role of VA-ECMO.[1]

不同产地牛蒡子的指纹图谱研究

应用HPLC对九个不同产地牛蒡子药材进行指纹图谱研究。使用岛津ODS柱(4.6mm×215;150mm,5μm),以乙腈–水为流动相,梯度洗脱,流动相流速:1.0mL-min-1,柱温:25℃,检测波长:280nm,得到11个共有峰,建立了牛蒡子药材的HPLC指纹图谱可用于牛蒡子药材的专属性鉴别,九个不同产地牛蒡子药材HPLC指纹图谱中,其相似度都大于0.99,说明不同产地的牛蒡子其质量的均一性很好。

Revolutionary meta-imaging:from superlens to metalens

The refractive-lens technique has been well developed over a long period of evolution,offering powerful imaging functionalities,such as microscopes,telescopes,and spectroscopes.Nevertheless,the ever-growing requirements continue to urge further enhanced imaging capabilities and upgraded devices that are more compact for convenience.Metamaterial as a fascinating concept has inspired unprecedented new explorations in physics,material science,and optics,not only in fundamental researches but also novel applications.Along with the imaging topic,this paper reviews the progress of the flat lens as an important branch of metamaterials,covering the early superlens with super-diffraction capability and current hot topics of metalenses including a paralleled strategy of multilevel diffractive lenses.Numerous efforts and approaches have been dedicated to areas ranging from the new fascinating physics to feasible applications.This review provides a clear picture of the flat-lens evolution from the perspective of metamaterial design,elucidating the relation and comparison between a superlens and metalens,and addressing derivative designs.Finally,application scenarios that favor the ultrathin lens technique are emphasized with respect to possible revolutionary imaging devices,followed by conclusive remarks and prospects.

Metamaterials:From fundamental physics to intelligent design

Metamaterials are artificial structures with the ability to efficiently control light-field,attracting intensive attention in the past few decades.People have studied the working principles,design strategies,and fabrication methods of metamaterials,making this field cross and combine with many disciplines,including physics,material science,electronics,and chemistry.In recent years,with the rapid development of high-efficiency and multifunctional metasurfaces,which are a two-dimensional version of metamaterials,great efforts have been made to push this material to practical applications.In particular,the introduction of artificial intelligent(AI)algorithms enables metamaterials-based photonic devices that exhibit excellent performances and intelligent functionalities.In this review,we first introduce the basic concepts,working principles,design methods,and applications of metamaterials,and then focus on the rapidly developing metamaterials research combined with AI algorithms.Finally,we conclude this review with personal perspectives on the current problems and future directions of metamaterials research and developments.

Co-regulation of mitochondrial and chloroplast function: Molecular components and mechanisms

The metabolic interdependence,interactions,and coordination of functions between chloroplasts and mitochondria are established and intensively studied.However,less is known about the regulatory components that control these interactions and their responses to external stimuli.Here,we outline how chloroplastic and mitochondrial activities are coordinated via common components involved in signal transduction pathways,gene regulatory events,and post-transcriptional processes.The endoplasmic reticulum emerges as a point of convergence for both transcriptional and post-transcriptional pathways that coordinate chloroplast and mitochondrial functions.Although the identification of molecular components and mechanisms of chloroplast and mitochondrial signaling increasingly suggests common players,this raises the question of how these allow for distinct organelle-specific downstream pathways.Outstanding questions with respect to the regulation of post-transcriptional pathways and the cell and/or tissue specificity of organelle signaling are crucial for understanding how these pathways are integrated at a wholeplant level to optimize plant growth and its response to changing environmental conditions.

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins

Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus.

A review on molten sulfate salts induced hot corrosion

Hot corrosion has been extensively observed in various high temperature applications,which might cause large economic losses.To deepen the insight and understanding of hot corrosion,herein,we provide a detailed discussion on hot corrosion induced by molten sulfate salt,in which Na_(2)SO_(4)is the main chemical reactant.The hot corrosion is triggered and sustained by the negative solubility gradient of protective oxide from the oxide/salt interface to salt/gas interface.In this work,we reviewed several key factors,including temperature,gas composition,molten salt composition,alloy element and external stress,influencing the hot corrosion of alloy beneath the molten salt.The application of anti-corrosion coating seems to be the most effective and commercial mothed to mitigate hot corrosion.Therefore,the progress of the development of effective coatings,e.g.,Ni-Cr coatings,aluminide coatings,silicide coatings and MCrAlY(X)coatings,has also been summarized.

Enhanced damping capacity of ferromagnetic Fe-Ga alloys by introducing structural defects

The irreversible motion of magnetic domain walls in ferromagnets can dissipate a large portion of the elastic energy,and the associated damping capacity is proportional to the magnetostriction constant.In contrast,here we found that the damping capacity of the large magnetostriction Fe-Ga alloys can be enhanced by 2-3 times through introducing structural defects including interfacial dislocations and stacking faults,despite that these defects deteriorate the magnetostriction.These structural defects were introduced by aging the BCC(body-centered-cubic)solution-treated precursor,for which the formation of mechanically harder FCT(face-centered-tetragonal)and/or FCC(face-centered-cubic)phases can result in high-density partial dislocations at the semi-coherent phase interfaces and quasi-periodically stacked nano-layer substructure inside the FCC variants.The structural defects act as extra damping sources besides the magnetic domain walls because the structural accommodation of the semi-coherent phase interfaces between BCC and FCT/FCC nanoprecipitates with different elastic moduli and the nano-layer substructure towards long-range ordered periodical stacking can dissipate a large portion of mechanical energy.These findings suggest that introducing structural defects provides fresh freedom to design high damping ferromagnetic materials.

蛭龙活血通瘀胶囊对颈动脉狭窄患者血脂及炎症反应的影响

目的:观察蛭龙活血通瘀胶囊对颈动脉狭窄患者的血脂及炎症反应的影响,评价其临床疗效。方法:颈动脉狭窄患者120例,按狭窄程度不同分为轻度、中度及重度三个亚组,各40例,各亚组随机分为对照组和治疗组,各20例。对照组给予基础治疗和阿托伐他汀钙片20 mg睡前服,治疗组在对照组基础上,予以蛭龙活血通瘀胶囊口服(1. 2 g,每日3次)。治疗周期为90 d。实验结束后观察各组患者IMT、Grouse积分、IMT变化,同时观测中医证候积分、疗效评价及血脂类、炎症反应类指标等。结果:颈动脉斑块:与治疗前比较,各组治疗后IMT、Grouse积分明显减少,与对照组比较,联用蛭龙活血通瘀胶囊能促进非稳定斑块向稳定斑块转化,以颈动脉轻度狭窄组改善更显著(P <0. 05或P <0. 01);中医证候:治疗组能明显改善不同程度颈动脉狭窄患者临床证候中医证候积分,改善患者头晕、头痛、心悸等不适(P <0. 05或P <0. 01);机制研究:与对照组比较,各组治疗后TC、TG、LDL-C含量明显降低,hs-CRP、TNF-α、IL-6的水平显著减少,以颈动脉轻度狭窄组改善最明显(P <0. 05或P <0. 01)。结论:蛭龙活血通瘀胶囊具有抗动脉粥样硬化和稳定斑块的作用,可能与其降脂、抗炎的作用有关。

Micro or nano:Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

In recent years,various particulate materials have played important roles in medical applications.However,nano-and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes.This finding provided a simple and effective way to improve the biological applications of particulate materials.Therefore,as a highly promising member,the effect of the particle size change of the magnesium metal organic framework-74(Mg-MOF74)was well worth evaluating.Here we firsth assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74(m-Mg-MOF74/n-Mg-MOF74)in detail.Our in vitro study revealed that compared to micron-sized subjects,n-Mg-MOF74 provided a wider range of safe concentrations.Furthermore,both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods,with n-Mg-MOF74 still showing lower cardiotoxicity.These advantages of nanoscale Mg-MOF74might benefit from its sustainable and balanced release of Ma^2+both inside and outside the cells.Based on the biosafety evaluation,advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were alsoperformed.Similarly,the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects.Overall,our combined data delineated the toxicity and biological behaviors of Ma-MOF74 of different scales,and sugqested nanoscale Mg-MOF74 as a better choice for future applications.This result revealed that particle size reductior might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

参照肛直线的内镜下套扎术治疗Ⅰ-Ⅲ度内痔临床效果研究

目的观察参照肛直线的内镜下套扎术(ERBL)治疗Ⅰ-Ⅲ度内痔的临床效果.方法回顾性分析2020年4月至2020年12月期间,河南省人民医院消化内科收治的67例进行参照肛直线的ERBL治疗并成功随访的Ⅰ-Ⅲ度内痔患者的临床资料,并对其一般资料、临床特点及治疗效果进行分析.结果67例患者中,Ⅰ度35例(52.2%)、Ⅱ度15例(22.4%)、Ⅲ度17例(25.4%);出血者35例(52.2%)、脱垂者9例(13.4%)、出血合并脱垂者23例(34.3%).手术成功率为100%,治疗总体有效率为88.1%(59/67),其中治愈38例(56.7%)、好转21例(31.3%)、复发2例(3.0%).术后不良事件方面,疼痛23例(34.3%),其中轻度11例(16.4%)、中度8例(11.9%)、重度4例(6.0%),疼痛患者术后用药百分比为17.4%(4/23),均为重度疼痛患者;肛门坠胀37例(55.2%)、尿潴留12例(17.9%)、发热1例(1.5%).结论参照肛直线的ERBL治疗Ⅰ-Ⅲ度内痔操作简单、安全、疗效显著.