Asymptotic Performance Limits of Vehicular Location and Velocity Detection Towards 6G mmWave Integrated Communication and Sensing

In this paper,joint location and velocity estimation(JLVE)of vehicular terminals for 6G integrated communication and sensing(ICAS)is studied.We aim to provide a unified performance analysis framework for ICAS-based JLVE,which is challenging due to random fading,multipath interference,and complexly coupled system models,and thus the impact of channel fading and multipath interference on JLVE performance is not fully understood.To address this challenge,we exploit structured information models of the JLVE problem to render tractable performance quantification.Firstly,an individual closedform Cramer-Rao lower bound for vehicular localization,velocity detection and channel estimation,respectively,is established for gaining insights into performance limits of ICAS-based JLVE.Secondly,the impact of system resource factors and fading environments,e.g.,system bandwidth,the number of subcarriers,carrier frequency,antenna array size,transmission distance,spatial channel correlation,channel covariance,the number of interference paths and noise power,on the JLVE performance is theoretically analyzed.The associated closed-form JLVE performance analysis can not only provide theoretical foundations for ICAS receiver design but also provide a perfor mance benchmark for various JLVE methods。

初诊大肿块弥漫性大B细胞淋巴瘤患者临床特征及预后分析

目的:分析初诊时伴有大肿块的弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者的临床特征与预后因素。方法:回顾性分析2018年1月至2021年9月郑州大学第一附属医院收治的194例大肿块DLBCL患者的临床资料,其中大肿块定义为肿瘤最大直径(maximum tumor diameter,MTD)≥7.5 cm,根据大肿块所在部位将患者分为:腹盆腔组、胸腔组、头颈部组。结果:194例大肿块DLBCL患者中位总生存(median overall survival,mOS)期为16(0~50)个月,患者1、3年总生存(overall survival,OS)率分别为75.6%、66.2%。1、3年无进展生存(progression-free survival,PFS)率分别为55.9%和44.1%。患者一线治疗后达到完全缓解(complete response,CR)、部分缓解(partial response,PR)、疾病稳定(stable disease,SD)、疾病进展(progressive disease,PD)分别为45例(23.2%)、78例(40.2%)、11例(5.7%)、60例(30.9%),一线治疗客观缓解率(overall response rate,ORR)为63.4%。单因素分析结果显示,年龄、Ann Arbor分期、β2-微球蛋白水平(β2-microglobulin,β2-MG)、有无中枢侵犯、是否放疗、大肿块所在部位是影响大肿块DLBCL患者OS的预后因素(P<0.05);Cox回归模型多因素分析结果显示,年龄>60岁、Ann Arbor分期Ⅲ/Ⅳ期、大肿块所在部位为腹盆腔组、头颈部组是大肿块DLBCL的独立不良预后因素(P<0.05)。腹盆腔组患者分期较晚、B症状多见、β2-微球蛋白水平多升高、C反应蛋白水平较高、Ki-67值较高;胸腔组年轻患者比例较高、临床分期较早、非GCB亚型更多见。腹盆腔组、胸腔组、头颈部组3组患者的3年OS率分别为60.4%、84.4%和54.2%,差异具有统计学意义(P<0.01)。结论:大肿块DLBCL患者肿瘤负荷高,一线治疗缓解率低、疾病进展率高,年龄>60岁、临床分期晚、大肿块所在腹盆腔组和头颈部组的患者预后较差。

Pharmacognosy Identification of Yi Medicinal Material Campanula colorata

[Objectives] To study the original plant,traits and microscopic identification for Yi medicinal material Campanula colorata,and provide experimental data for its identification and medicinal use. [Methods] Plant identification,trait identification,powder identification and paraffin slice identification were adopted in the study. [Results]It was found that the original plant of Campanula colorata was characterized by stiff hairs,slightly thicker root than stem,serrated leaf margin,tubular bell-shaped corolla and blue-purple color; traits were featured by odorlessness,and bitter taste after slight sweetness; the microscopic identification characteristics were that the laticifer was sporadic,containing reddish brown or yellow brown materials,and the oil droplets and nonglandular hairs were common. [Conclusions] The original plant,trait and microscopic identification characteristics were obvious for Yi medicinal material Campanula colorata,which could provide a reference for developing quality standards and identifying the original plant of Campanula colorata,and provide the basis for further research and development.

BTK抑制剂在中枢神经系统淋巴瘤中的治疗作用及安全性分析

目的:研究布鲁顿酪氨酸激酶(Bruton's tyrosine kinase,BTK)抑制剂治疗复发/难治性中枢神经系统淋巴瘤(relapsed/refractory central nervous system lymphoma,R/R CNSL)的有效性和安全性。方法:回顾性分析郑州大学第一附属医院2018年10月至2021年10月收治的43例R/R CNSL患者,分别使用BTK抑制剂单药、BTK抑制剂联合化疗、BTK抑制剂联合免疫治疗方案,BTK抑制剂包括伊布替尼、泽布替尼、奥布替尼,初始剂量分别为(420~560)mg/d、320 mg/d、(100~150)mg/d,分析治疗后的最好疗效和不良反应。结果:BTK抑制剂单药组(A组)、BTK抑制剂联合化疗组(B组)、BTK抑制剂联合免疫治疗组(C组)的客观缓解率(objective response rate,ORR)分别为44.4%、85.7%和76.9%,B组的ORR高于A、C组,原发中枢神经系统淋巴瘤(primary CNSL,PCNSL)患者的ORR(78.6%vs.66.7%)高于继发中枢神经系统淋巴瘤(secondary CNSL,SCNSL)患者,两者的无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)差异均无统计学意义(均P>0.05)。3/4级不良反应主要为白细胞减少、血小板减少、贫血。贫血。结论:BTK抑制剂单药及联合方案对R/R CNSL患者疗效可,不良反应可耐受。

Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China

Background：The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods：A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles（DDGS） as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography（HPLC） in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,（AFB,）,deoxynivalenol（DON）,zearalenone（ZEA） and ochratoxin A（OTA） in the ingredients and complete feeds.Results：DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions：This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China＇s Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA.

Shorter alkyl chain in thieno[3,4-c]pyrrole-4,6-dione(TPD)-based large bandgap polymer donors – Yield efficient non-fullerene polymer solar cells

Typically,conjugated polymers are composed of conjugated backbones and alkyl side chains.In this contribution,a cost-effective strategy of tailoring the length of alkyl side chain is utilized to design highperforming thieno[3,4-c]pyrrole-4,6-dione(TPD)-based large bandgap polymer donors PBDT-BiTPD(Cχ)(χ=48,52,56),in which x represents the alkyl side chain length in term of the total carbon number.A combination of light absorption,device,and morphology examinations make clear that the shorter alkyl side chains yield(i) higher crystallinity and more predominant face-on crystallite orientation in their neat and BHJ blend films,(ii) higher charge mobilities(6.7×10^(-4) cm~2 V^(-1) s^(-1) for C48 vs.3.2×10^(-4) cm~2 V^(-1) s^(-1) for C56),and negligible charge recombination,consequently,(iii) significantly improved fill-factor(FF) and short current(J_(SC)),while almost the same open circuit voltage(V_(OC)) of ca.0.82 V in their corresponding BHJ devices.In parallel,as alkyl side chain lengths decrease from C56 to C48,power conversion efficiencies(PCEs) increased from 7.8% for C56 to 11.1% for C52,and further to14.1% for C48 in their BHJ solar cells made with a narrow bandgap non-fullerene acceptor Y6.This systematic study declares that shortening the side chain,if providing appropriate solubility in device solution processing solvents,is of essential significance for developing high-performing polymer donors and further improving device photovoltaic performance.

Study on In vitro Regeneration System of Melon

[ Objective] This study aimed to optimize the in vitro regeneration system of melon. [ Method] Melon variety Nanxiang91023 was selected as experi- mental materials, with the cotyledons and hypocotyls as explants, different types and concentrations of growth regulators were supplemented at different stages of tis- sue culture, to explore the simple and effective medium formula for regeneration of melon. [ Result] MS ＋ 1.5 mg/L of 6-BA ＋0.2 mg/L of LAA was the optimal medium for induction and proliferation of callus; MS ＋ 1.0 mg/L of 6-BA ＋ 0. 2 mg/L of 2, 4-D was the optimal medium for differentiation of adventitious buds; MS ＋ 1.0 mg/L of ZT ＋ 0.2 mg/L of LAA was the optimal medium for rooting of seedlings. On the basis of above conditions, melon seedlings had high roofing rate and strong roots. [ Conclusion] This study provided a guarantee for the further genetic transformation of improved melon varieties.

Evaluation of Ambient Air Quality and Its Changing Trend in Jinan City during 2013-2020

Based on the automatic monitoring data of ambient air in Jinan City from 2013 to 2020,the changing trend and characteristics of air quality in Jinan City during 2013-2020 were analyzed by using the fuzzy comprehensive evaluation,air quality index(AQI)and ambient air quality comprehensive index methods.The three methods are different in principle,purpose of use,and characterization methods,but the conclusions are consistent.The ambient air quality in Jinan City was improved significantly from 2013 to 2020.The prime pollutants were mainly PM_(2.5)and PM_(10),but the impact on air quality declined,and the impact of O_(3)on air quality increased.The complex pollution characteristics were obvious.Air pollution was the most severe in winter and lighter in summer.

In vitro Antioxidant Activity of Extracts from Eleutherine plicata Herb by Different Extraction Methods

[Objectives] To study in vitro antioxidant activity of extracts from Eleutherine plicata Herb by different extraction methods.[Methods]1,1-diphenyl-2-picrylhydrazyl( DPPH) free radical scavenging method,2,2'-Azinobis( 3-ehtylbenzothiazolin-6-sulfnic acid) diammonium salt( ABTS) free radical scavenging method,and iron ion reduction ability determination method were applied to measure the extracts of Eleutherine plicata Herb by ethanol extraction,water extraction,and ethanol extraction after water extraction,and comparison was made with positive control Vc( vitamin C). [Results]The ethanol extract,water extract,and ethanol extract after water extraction of Eleutherine plicata Herb had a high DPPH free radical,ABTS free radical scavenging activity,and reducing activity. [Conclusions]E. plicata Herb is a natural antioxidant with high potential.

一种用于肼氧化-复合海水电解制氢的富吡啶氮碳纸

丰富的中性海水有望替代高纯淡水用于绿氢制备,然而基于过渡金属材料催化的直接海水电解会因析氯反应(ClER)引发严重的腐蚀问题并造成二次重金属污染,且析氧反应(OER)的动力学缓慢.本工作中,我们报道了一种稳定的富吡啶氮的碳纸(N-CP-800),可以有效地催化肼氧化反应(HzOR),以取代中性海水中的OER用于节能制氢.结合电化学实验、原位衰减全反射-表面增强傅里叶变换红外光谱表征和密度泛函理论计算,我们发现:相较于吡咯氮和石墨氮,zig和arm构型的吡啶氮更有利于决速步(^(*)H+N_(2)H_(1))的质子脱附,以促进肼氧化反应.因此,N-CP-800在中性介质中进行HzOR时,仅需0.78 V(相对于可逆氢电势)便可达到10 mA cm^(-2),低于其OER/ClER竞争反应.当N-CP-800与非贵金属析氢催化剂CoP耦合进行HzOR-复合海水电解时,仅需1.56 V的电压即可达到10 mA cm^(-2),并能稳定运行200 h,优于Pt/C和RuO_(2)标准电极对催化的海水电解.

Clinical observation on prevention and treatment of radiation-induced parotid-gland injury in patients with nasopharyngeal carcinoma by Compound Sarcandra Glabra

Objective:To investigate the protective effect of the Compound Sarcandra Glabra on radiation injury of parotid glands in patients with nasopharyngeal carcinoma.Methods:Sixty patients with primary nasopharyngeal carcinoma in the First Affiliated Hospital of Guangxi Medical University from June 2018 to January 2019 were collected,which were divided into treatment group and control group using a random number table.All patients were treated by a combination of 9-field intense-modulated radiotherapy and chemotherapy.The treatment group was given the Compound Sarcandra Glabra orally every day from 3 days before radiotherapy to the end.The degree of xerostomia(dry mouth)of patients was compared between the two groups at the end of radiotherapy and 3 months after radiotherapy by the chi-square test.The maximal adsorption and secretion rates of the parotid glands were compared between groups before radiotherapy,at the end of radiotherapy and 3 months after radiotherapy by the independent sample t-test.Results:The symptoms of dry mouth were alleviated in the treatment group,and the degree of dry mouth significantly differed between groups at the end of radiotherapy and 3 months after radiotherapy(χ2=6.696 and 10.977,P<0.05).There were no significant differences in the maximal adsorption and secretion rates of the parotid glands between groups before radiotherapy(t=0.974 and4.646,P>0.05);however,both variables were significantly higher in the treatment group at the end of radiotherapy and 3 months after radiotherapy(t=2.920 and 5.037;t=2.820 and 2.213,P<0.05).Patients presented no liver and kidney injury after radiotherapy.Conclusions:Oral administration of the Compound Sarcandra Glabra can effectively prevent radiation injury of the parotid glands in patients with nasopharyngeal carcinoma,thereby alleviating the degree of dry mouth after radiotherapy.

基于翻转课堂的协作学习效果实证分析——以大学生“计算机网络与应用”课程为例

翻转课堂赋予学生充分的时间开展协作学习,从而避免传统课堂中协作学习流于形式的问题。为探究翻转课堂对学生协作学习效果的影响,本研究设计了基于翻转课堂的协作学习模式,以大学课程中的"计算机网络与应用"课程为案例,检验了该模式下翻转课堂对协作学习效果的影响。结果表明:翻转课堂对学生协作学习中面对面交流互动、个人责任、社会交往和小组协作技能以及个人协作绩效有显著影响,但对积极相互依赖以及小组自加工等影响不显著。该研究结果在一定程度上表明,翻转课堂能够促进学生协作学习中面对面交流互动,提升社会交往和小组协作技能,增强学生协作学习中的个人责任感及提高个人协作学习绩效,翻转课堂中教学环境的提升和教师素养的提高有助于学生协作学习的开展。本研究旨在为促进师生在翻转课堂中开展协作学习提供参考。

Comparative analysis of habitation behavioral patterns in spatial configuration of traditional houses in Anhui;Jiangsu;and Zhejiang provinces of China

This study investigated the categories of spatial characteristics of traditional houses in Anhui,Jiangsu,and Zhejiang provinces of China by applying syntactic theories and conducting a comparative analysis of their different layout configurations.Six houses in the three provinces were selected as measurement samples,and statistical analysis of their spatial variables was conducted through SPSS 22.Results showed that the correlation of depth and integration in the Zhejiang and Jiangsu samples are negative,whereas the samples in Anhui show no correlation.These results further indicated that spaces with high rates of utilization in Zhejiang and Jiangsu dwellings are located at low depths in the spatial configurations,whereas the samples from Anhui show opposite findings.Different housing spatial structures reflect various habitation behavioral patterns in this area.Zhejiang and Jiangsu residents interact more closely with outside spaces in their daily lives,whereas Anhui residents have very limited interaction with outside spaces,thereby reflecting two different modes of living behavior,namely,extroversion and introversion.

可见光氧化还原催化制备β-硝基酮

β-胺基酮在天然产物和药物合成方面具有极其重要的价值.Mannich反应是合成β-胺基酮的重要方法,但仍然存在局限性:无法合成-NH_(2)未被修饰的β-氨基酮或-NH_(2)连在β-季碳上的酮.本文利用可见光诱导的氧化还原催化,由烯醇三甲基硅醚与偕溴代硝基烃在温和条件下制备各种β-硝基酮,包括硝基连在β-季碳上的酮.这些结构新颖的β-硝基酮很容易转化为β-NH_(2)酮、1,3-氨基醇、α,β-不饱和酮、β-氰基酮和γ-硝基酮.

vsx1 3' untranlated region-mediated translation difference at different developmental stages of goldfish embryos

Visual system homeobox-1 （vsxl） is important in retinal progenitor proliferation, differentiation, and function maintenance of bipolar cells in vertebrates. Recent study in Xenopus laevis has shown that vsxl 3＇ untranslated region （3＇ UTR） can mediate cell-specific translation of vsxl mRNA in the bipolar cells of the retinal inner nuclear layer （INL）. vsxl is also transcribed at the early developmental stages prior to eye formation and its spatiotemporal expression patterns are conserved in all the examined vertebrates. In order to determine whether the vsxl 3＇ UTR has a role in regulating the spatiotemporal expression of vsxl during early embryogenesis, we constructed a vsxl UTR-controlled green fluorescent protein （GFP） reporter gene system and examined the GFP expression pattern in goldfish, Carassius auratus, at different developmental stages, Our results indicated that both the vsxl 5＇ UTR and the vsxl 3＇ UTR remarkably repressed GFP expression at transcription level but did not regulate tissue-specific translation at early developmental stages. GFP protein was ubiquitously expressed in the embryos injected with GFP-sensors containing vsxl UTRs before 60 h post-fertilization （hpf）. From hatching stage （72 hpf） onwards, however, GFP protein was specifically expressed in the bipolar cells of the retinal 1NL in the vsxl 3＇UTR-GFP-sensor embryos, but was still ubiquitously expressed in the embryos injected with GFP-sensor lacking vsxl 3＇ UTR. These observations showed a significant difference of vsxl 3＇ UTR-mediated translation between early and late developmental stages and suggested that vsxl 3＇ UTR might not be involved in regulating the spatiotemporal expression of vsxl until hatching stage during embryogenesis.