Natural extracellular vesicles(EVs)play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges.Investigating the origins and working mechanisms of...Natural extracellular vesicles(EVs)play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges.Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities,especially regarding the occurrence and development of diseases.Additionally,due to their vesicular structure,EVs(in small molecules,nucleic acids,proteins,etc.)could act as efficient drug-delivery carriers.Herein,we describe the sources and biological functions of various EVs,summarize the roles of EVs in disease diagnosis and treatment,and review the application of EVs as drug-delivery carriers.We also assess the challenges and perspectives of EVs in biomedical applications.展开更多
基金funded by the National Natural Science Foundation of China(31901007,81630023,81970852,and 82000962)CAMS Innovation Fund for Medical Sciences,China(2018-I2M-3-006 and 2019-I2M-5-022,China)+6 种基金China Postdoctoral Science Foundation(2020T130006ZX)the Open Project Fund provided by Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS(NSKF202019,China)the State Key Laboratory Special Fund 2060204the National Key R&D Program of China(2016YFC0905200)the program for the Changjiang scholars and innovative research team(IRT13082,China)the Beijing Bai-Qian-Wan talent project(2019A32,China)the Public Welfare Development and Reform Pilot Project(2019-10,China)
文摘Natural extracellular vesicles(EVs)play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges.Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities,especially regarding the occurrence and development of diseases.Additionally,due to their vesicular structure,EVs(in small molecules,nucleic acids,proteins,etc.)could act as efficient drug-delivery carriers.Herein,we describe the sources and biological functions of various EVs,summarize the roles of EVs in disease diagnosis and treatment,and review the application of EVs as drug-delivery carriers.We also assess the challenges and perspectives of EVs in biomedical applications.
