Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)

The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system.

A Therapeutic Sheep in Metastatic Wolf’s Clothing: Trojan Horse Approach for Cancer Brain Metastases Treatment

Early-stage brain metastasis of breast cancer(BMBC), due to the existence of an intact blood–brain barrier(BBB), is one of the deadliest neurologic complications. To improve the efficacy of chemotherapy for BMBC, a Trojan horse strategy-based nanocarrier has been developed by integrating the cell membrane of a brain-homing cancer cell and a polymeric drug depot. With the camouflage of a MDA-MB-231/Br cell membrane, doxorubicin-loaded poly(D, L-lactic-co-glycolic acid) nanoparticle(DOX-PLGA@CM) shows enhanced cellular uptake and boosted killing potency for MDA-MB-231/Br cells. Furthermore, DOX-PLGA@CM is equipped with naturally selected molecules for BBB penetration, as evidenced by its boosted capacity in entering the brain of both healthy and early-stage BMBC mouse models. Consequently, DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, slows down cancer progression, reduces tumor burden, and extends the survival time for the BMBC animal.Furthermore, the simplicity and easy scale-up of the design opens a new window for the treatment of BMBC and other brain metastatic cancers.

Dynamic Fatigue Reliability Analysis of Transmission Gear Considering Failure Dependence

Multiple failuremodes and strength degradation are usually inherent in the gear transmission system,which brings new challenges for conducting fatigue reliability analysis and design.This paper proposes a novel dynamic fatigue reliability analysis method for failure dependence and strength degradation based on the combination of theCopula function and Gamma process.Firstly,the dynamic simulation model of the gear transmission system is established to obtain the dynamic stress-time history.The Gamma process is then used to describe the strength degradation to establish the dynamic stress-strength interference model.The marginal distribution functions of tooth contact fatigue and dedendumbending fatigue are calculated respectively based on the dynamic interferencemodel.Finally,the joint distribution of the two failure modes can be obtained by the t-Copula function to characterize the failure dependence,and so the dynamic fatigue reliability considering failure dependence can be estimated.The effectiveness of the proposed method is illustrated with examples.The results reveal the temporal law of reliability and the effects of failure dependence on dynamic fatigue reliability.

Micromechanical modeling of longitudinal tensile behavior and failure mechanism of unidirectional carbon fiber/aluminum composites involving fiber strength dispersion

This paper examines the longitudinal tensile behavior and failure mechanism of a new unidirectional carbon fiber reinforced aluminum composite through experiments and simulations.A Weibull distribution model was established to describe the fiber strength dispersion based on single-fiber tensile tests for carbon fibers extracted from the composite.The constitutive models for the matrix and interface were established based on the uniaxial tensile and single-fiber push-out tests,respectively.Then,a 3D micromechanical numerical model,innovatively considering the fiber strength dispersion by use of the weakest link and Weibull distribution theories,was estab-lished to simulate the progressive failure behavior of the composite under longitudinal tension.Due to the dispersion of fiber strength,the weakest link of the fiber first fractures,and stress concentra-tion occurs in the surrounding fibers,interfaces,and matrix.The maximum stress concentration fac-tor for neighboring fibers varies nonlinearly with the distance from the fractured fiber.Both isolated and clustered fractured fibers are present during the progressive failure process of the composite.The expansion of fractured fiber clusters intensifies stress concentration and material degradation which in turn enlarges the fractured fiber clusters,and their mutual action leads to the final collapse of the composite.

Synthesis of Tetrathiophosphates from White Phosphorus

Comprehensive Summary,A transition-metal-free one-pot direct synthesis of tetrathiophosphates(R^(1)S)_(2)P(S)SR^(2) from white phosphorus(P_(4)),through intermediate sodium alkyltetrathiophosphates(R^(1)S)_(2)P(S)SNa,is presented.In the presence of NaSH,various disulfides such as diaryl disulfidbges and dialkyl disulfides are easily coupled with P_(4) to give sodium alkyltetrathiophosphates(R^(1)S)_(2)P(S)SNa in almost quantitative yield,which react with alkyl halides in one pot to generate(R^(1)S)_(2)P(S)SR2.Furthermore,S-(2-cyanoethyl)-substituted tetrathiophosphates(R^(1)S)_(2)P(S)SCH_(2)CH_(2)CN are successfully designed as a kind of tetrathiophosphorylation reagent to react with diaryl iodonium salts involving deprotection-dealkylation process.

Indoor distribution and personal exposure of cooking-generated PM2.5 in rural residences of China:A multizone model study

The fine particulate matter(PM2.5)emitted during cooking is a significant contributor to household air pollution in rural China,resulting in millions of premature deaths annually.Since cooking is an internal pollution source,the indoor concentration of cooking-generated PM2.5 can vary among different rooms in multizone rural residences.This study provides a comprehensive understanding of indoor PM2.5 from cooking in rural residences by utilizing on-site investigations to gather information on cooking behavior and dwelling layout in three Chinese villages,and subsequently simulating indoor spatiotemporal concentrations of cooking-generated PM2.5 using a multizone model.Our findings indicate that the type of zone significantly influences the zonal concentration of PM2.5,with the highest concentrations found in kitchens(i.e.,13.9 to 188.0μg/m3)and lowest in non-adjacent zones to the kitchen(i.e.,0.01 to 7.5μg/m3)among all the modeled conditions.More importantly,the study also assesses the resulting personal exposures for occupants with different time-spent patterns,revealing that the main cook at home and preferring to stay in the adjacent rooms to the kitchen are at the highest risk for personal exposure.The highest personal exposure levels of cooking-generated PM2.5 are 28.5±30.1μg/m3,which is 34 times that of occupants who stay away from the kitchen.The study provides a deeper scientific insight into the indoor spatial distribution and personal exposure to cooking-generated PM2.5 in rural residences,which is crucial for developing effective interventions to mitigate the detrimental health impacts of household air pollution in rural areas.

An unusual cause of cyanosis after intra-extra cardiac Fontan procedure: anastomotic leakage between conduit and inferior vena cava

A child aged 7 years was admitted to our hospital nearly 5 years after an intra-extra cardiac Fontan operation due to aggravated cyanosis.He was diagnosed with pulmonary atresia(PA),atrial septal defect,patent ductus arteriosus(PDA)and thickened tricuspid valve with severe regurgitation 1 month after being born,which was considered PA with intact ventricular septum(IVS)with severely hypoplastic right ventricle and was similar to functional single ventricle.

An Optimization Approach for Stiffener Layout of Composite Stiffened Panels Based on Moving Morphable Components(MMCs)

An explicit topology optimization method for the stiffener layout of composite stiffened panels is proposed based on moving morphable components(MMCs).The skin and stiffeners are considered as panels with different bending stiffnesses,with the use of equivalent stiffness method.Then the location and geometric properties of composite stiffeners are determined by several MMCs to perform topology optimization,which can greatly simplify the finite element model.With the objective of maximizing structural stiffness,several typical cases with various loading and boundary conditions are selected as numerical examples to demonstrate the proposed method.The numerical examples illustrate that the proposed method can provide clear stiffener layout and explicit geometry information,which is not limited within the framework of parameter and size optimization.The mechanical properties of composite stiffened panels can be fully enhanced.

Trace Nb-doped Na_(0.7)Ni_(0.3)Co_(0.1)Mn_(0.6)O_(2) with suppressed voltage decay and enhanced low temperature performance

The P2-type manganese-based Na_(0.7)MnO_(2) cathode materials attract great interest due to their high theoretical capacity.However,these materials suffer from rapid capacity fading,poor rate performance and severe voltage decay resulting from phase transition and sluggish reaction kinetics.In this work we report a novel Nb-doped Na_(0.7)[Ni_(0.3)Co_(0.1)Mn_(0.6)]_(1-x)Nb_(x)O_(2) with significantly suppre ssed voltage decay and enhanced cycling stability.The strong Nb-O bond can efficiently stabilize the TMO fra mework,and the as prepared material demonstrates much lower discharge midpoint voltage decay(0.132 V) than that of pristine one(0.319 V) after 200 cycles.Consequently,a remarkably improved cycling perfo rmance with a capacity retention of 87.9% after 200 cycle at 0.5 C is achieved,showing a 2.4 fold improvement as compared to the control sample Na_(0.7)Ni_(0.3)Co_(0.1)Mn_(0.6)O_(2)(~37% rotation).Even at 2 C,a capacity retention of 68.4% is retained after 500 cycles.Remarkably,the as prepared material can be applied at low temperature of-20℃,showing a capacity retention of 81% as compared to that at room temperature.

A robust carbon coating of Na_(3)V_(2)(PO_(4))_(3)cathode material for high performance sodium-ion batteries

Na_(3)V_(2)(PO_(4))_(3)is a very prospective sodium-ion batteries(SIBs)electrode material owing to its NASICON structure and high reversible capacity.Conversely,on account of its intrinsic poor electronic conductivity,Na_(3)V_(2)(PO_(4))_(3)electrode materials confront with some significant limitations like poor cycle and rate performance which inhibit their practical applications in the energy fields.Herein,a simple two-step method has been implemented for the successful preparation of carbon-coated Na_(3)V_(2)(PO_(4))_(3)materials.As synthesized sample shows a remarkable electrochemical performance of 124.1 mAh/g at 0.1 C(1 C=117.6 mA/g),retaining 78.5 mAh/g under a high rate of 200 C and a long cycle-performance(retaining 80.7 mAh/g even after 10000 cycles at 20 C),outperforming the most advanced cathode materials as reported in literatures.

Advanced treatment of wet-spun acrylic fiber manufacturing wastewater using three-dimensional electrochemical oxidation

A three-dimensional electrochemical oxidation （3D-EC） reactor with introduction of activated carbon （AC） as particle micro-electrodes was apphed for the advanced treatment of secondary wastewater effluent of a wet-spun acrylic fiber manufacturing plant. Under the optimized conditions （current density of 500 A/m2, circulation rate of 5 mL/min, AC dosage of 50 g, and chloride concentration of 1.0 g/L）, the average removal efficiencies of chemical oxygen demand （CODer）, NH3-N, total organic carbon （TOC）, and ultraviolet absorption at 254 nm （UV2s4） of the 3D-EC reactor were 64.5%, 60.8%, 46.4%, and 64.8%, respectively; while the corresponding effluent concentrations of CODcr, NH3-N, TOC, and UV2s4 were 76.6, 20.1, and 42.5 mg/L, and 0.08 Abs/cm, respectively. The effluent concentration of CODer was less than 100 mg/L, which showed that the treated wastewater satisfied the demand of the integrated wastewater discharge standard （GB 8978-1996）. The 3D-EC process remarkably improved the treatment efficiencies with synergistic effects for CODer, NH3-N, TOC, and UV2s4 during the stable stage of 44.5%, 38.8%, 27.2%, and 10.9%, respectively, as compared with the sum of the efficiencies of a two-dimensional electrochemical oxidation （2D-EC） reactor and an AC adsorption process, which was ascribed to the numerous micro-electrodes of AC in the 3D-EC reactor. Gas chromatography mass spectrometry （GC-MS） analysis revealed that electro- chemical treatment did not generate more toxic organics, and it was proved that the increase in acute biotoxicity was caused primarily by the production of free chlorine.

Early prediction of acute kidney injury in neonates with cardiac surgery

Background Acute kidney injury(AKI)occurs in 42%-64%of the neonatal patients experiencing cardiac surgery,contributing to postoperative morbidity and mortality.Current diagnostic criteria,which are mainly based on serum creatinine and hourly urine output,are not sufficiently sensitive and precise to diagnose neonatal AKI promptly.The purpose of this review is to screen the recent literature,to summarize the novel and cost-effective biomarkers and approaches for neonatal AKI after cardiac surgery(CS-AKI),and to provide a possible research direction for future work.Data sources We searched PubMed for articles published before November 2019 with pertinent terms.Sixty-seven articles were found and screened.After excluding 48 records,19 articles were enrolled for final analysis.Results Nineteen articles were enrolled,and 18 possible urinary biomarkers were identified and evaluated for their ability to diagnose CS-AKI.Urinary neutrophil gelatinase-associated lipocalin(uNGAL),serum cystatin C(sCys),urinary human kidney injury molecule-1(uKIM-1),urinary liver fatty acid-binding protein(uL-FABP)and interleukin-18(uIL-18)were the most frequently described as the early predictors of neonatal CS-AKI.Conclusions Neonates are vulnerable to CS-AKI.UNGAL,sCys,uL-FABP,uKIM-1 and uIL-18 are potential biomarkers for early prediction of neonatal CS-AKI.Renal regional oxygen saturation by near-infrared spectroscopy is a non-invasive approach for early identification of neonatal AKI.Further work should focus on exploring a sensitive and specific combined diagnostic model that includes novel biomarkers and other complementary methods.

Combined Heat, Air, Moisture and Pollutant Simulations (CHAMPS) research for building and urban energy efficiency and environmental quality analysis

The energy and environmental performance of buildings and communities depends on how the heat,air,moisture and pollutant flows are managed and controlled in the system.Combined Heat,Air,Moisture and Pollutant Simulations(CHAMPS)research and development is vital to the optimal design and operation of building and urban energy and environmental systems.