Study on the Clinical Application of Nutritional Management Combined with Clinical Monitoring of Glycated Albumin in Diabetic Nephropathy Dialysis Patients

Objective:To explore the clinical application of nutritional management combined with clinical monitoring of glycated albumin(GA)in diabetic nephropathy(DN)dialysis patients.Methods:A total of 20 diabetic nephropathy dialysis patients admitted to the People’s Hospital of Guandu District from January 2022 to February 2023 were included in the study.They were randomly divided into a conventional group(n=10)and an observation group(n=10).The study evaluated the blood glucose control,nutritional status,dialysis efficacy,and quality of life scores of both groups.Results:Before the intervention,there were no significant differences in fasting plasma glucose(FPG),GA,serum albumin,body mass index(BMI),dialysis efficiency values,urea clearance rate,or quality-of-life scores between the two groups(P>0.05).After the intervention,the observation group showed significantly lower FPG and GA levels,higher serum albumin,dialysis efficiency values,urea clearance rate,and improved quality-of-life scores compared to the conventional group(P<0.05),with no difference in BMI(P>0.05).Conclusion:Nutritional management combined with clinical monitoring of glycated albumin has a significant effect on the clinical application of diabetic nephropathy dialysis patients.It can effectively improve patients’blood glucose control and nutritional status,reduce the risk of complications,and enhance the quality of life,demonstrating clinical value for broader application.

Research Progress on the Efficacy and Safety of Different Basal Insulins in the Treatment of Type 2 Diabetes Mellitus

Objective:To evaluate the efficacy and safety of different basal insulins in the treatment of type 2 diabetes mellitus(T2DM).Methods:The current research progress on different basal insulins was evaluated,with efficacy indicators including fasting plasma glucose(FPG)and glycated hemoglobin(HbAic),and safety indicators focusing mainly on weight change and the incidence of hypoglycemia.Results:Several different basal insulins showed similar metabolic control effects in terms of fasting plasma glucose and glycated hemoglobin.However,the risk of hypoglycemia was lower with insulin glargine 300(Glar-300),insulin degludec 100(Deg-100),and insulin degludec 200(Deg-200)compared to insulin glargine 100(Glar-100).Additionally,Glar-300 had the least impact on weight.Conclusion:For the treatment of T2DM,different basal insulins have similar therapeutic effects,but there are differences in the incidence of hypoglycemic events and their impact on weight.Rational insulin selection and dosage adjustments should be made based on the different patient groups.

The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice

In this study,Tremella fuciformis residues as raw material,dietary fibers from tremella were prepared by multiple enzymes.The structure of dietary fibers from tremella was studied by Fourier transform infrared(FTIR),X-ray diffraction analysis(XRD)and scanning electron microscopy(SEM).We analyzed their lipidlowering properties in vitro(water holding,oil holding swelling cholesterol and sodium cholate binding capacitises)and the hypolipidemic effects in mice.The results showed that tremella dietary fibers presented the infrared absorption spectrum characteristics of polysaccharides and the characteristic diffraction peaks of cellulose type I.SEM results indicated that the surface of insoluble dietary fiber(IDF)was porous,while the soluble dietary fiber(SDF)was relatively compact and spongy.IDF exhibited significantly higher water holding,oil holding,and swelling binding capacities than the corresponding SDF.However,SDF exhibited significantly higher viscosity than IDF.The results showed tremella dietary fibers were significant in swelling,water holding and oil holding,cholesterol and bile acids.In vivo experiment results in mice indicated that SDF has the best effect on hyperlipidemia mice than IDF and total dietary fiber(TDF).SDF showed that the total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)contents dropped by 28.33%,18.65%,and 48.97%,respectively,while high density lipoprotein cholesterol(HDL-C)content increased by 43.80%.Compared with the high-fat control(HCM)group,the arteriosclerosis index(AI)and liver index(LI)of the SDF group mice showed significant differences,indicating that SDF has a good auxiliary effect of lowering blood lipids.The administration of tremella fibers improved the lipid metabolism disorderly situation of hyperlipidemia mice.These results provide a reference for further research and rational development of T.fuciformis.

一例日沟维肠杆菌污染化妆品情况分析

按照《化妆品安全技术规范》(2015年版)对1批化妆品中菌落总数和6批化妆品中防腐剂进行检测;用VITEK MS微生物质谱检测系统和16s rRNA基因测序对化妆品中的污染菌进行鉴定;每月转接一次观察日沟维肠杆菌置常温条件下存活情况;用日沟维肠杆菌对5批次含羟苯甲酯的化妆品进行防腐剂挑战试验。结果显示,1批菌落总数超标的化妆品,其污染菌鉴定为日沟维肠杆菌,该批化妆品使用的防腐剂含量为0.15%羟苯甲酯。日沟维肠杆菌在常温营养条件较好的情况下可存活10个月以上。羟苯甲酯含量为0.2%的3批化妆品和羟苯甲酯含量为0.1%+双咪唑烷基脲1批化妆品通过了日沟维肠杆菌防腐剂挑战试验。羟苯甲酯含量为0.1%的化妆品未通过日沟维肠杆菌防腐剂挑战试验。日沟维肠杆菌对化妆品中常用防腐剂羟苯甲酯具有耐药性,选择该类防腐剂时推荐使用日沟维肠杆菌进行防腐剂挑战试验判定其适用性。

Effect of Tremella fuciformis polysaccharide on the stalling and flavor of tteok during storage

The effect of Tremella fuciformis polysaccharide(TFP)on the retrogradation property and aroma profile changes of tteok during storage was investigated.Results indicated that addition of TFP significantly increased the stability to thermal and mechanical shearing of starch,decreased short-term retrogradation,the hardness and the retrogradation enthalpy(ΔH)of tteok during storage,but had no significant effect on the amylopectin chain length of tteok.The possible mechanism for the retarding staling effect of TFP is related to the interaction between TFP and starch chains that interferes with the alignment of starch chains.Electronic nose and g as chromatography-mass spectrum(GC-MS)analysis results showed that the difference in the concentrations of volatile compounds and fatty acids of tteoks at different storage time gradually increased with the advancement of storage period.The addition of TFP to tteok inhibited the development of unpleasant volatile compounds,probably by delaying the oxidation and decomposition of lipids and preserving the antioxidant phenolic compounds in tteok,thus slowing down the flavor deterioration of tteok and contributing to flavor maintainace.Overall,this study could help food manufacturers to choose a high-effective and natural polysaccharide to control the retrogradation rate and flavor loss of tteok.

Healthy function and high valued utilization of edible fungi

Edible fungi are large fungi with high added value that can be utilized as resources.They are rich in high-quality protein,carbohydrate,various vitamins,mineral elements and other nutrients,and are characterized by high protein,low sugar,low fat and low cholesterol.In addition,edible fungi contain a variety of bioactive substances,such as polysaccharides,dietary fiber,steroids,polyphenols,and most of these compounds have antioxidant,anti-tumor and other physiological functions.This review comprehensively discusses the bioactive components and functional characteristics of edible fungi(such as antioxidant,anti-aging,hypolipidemic activities,etc.).Then the recent developments and prospect in the high-valued utilization of edible fungi are discussed and summarized.The objective of this review is to improve the understanding of health-promoting properties of edible fungi,and provide reference for the industrial production of edible fungi-based health products.

Response of the sensorimotor cortex of cerebral palsy rats receiving transplantation of vascular endothelial growth factor 165-transfected neural stem cells

Neural stem cells are characterized by the ability to differentiate and stably express exogenous ge- nes. Vascular endothelial growth factor plays a role in protecting local blood vessels and neurons of newborn rats with hypoxic-ischemic encephalopathy. Transplantation of vascular endothelial growth factor-transfected neural stem cells may be neuroprotective in rats with cerebral palsy. In this study, 7-day-old Sprague-Dawley rats were divided into five groups： （1） sham operation （control）, （2） cerebral palsy model alone or with （3） phosphate-buffered saline, （4） vascular en- dothelial growth factor 165 ＋ neural stem cells, or （5） neural stem cells alone. The cerebral palsy model was established by ligating the left common carotid artery followed by exposure to hypox- ia. Phosphate-buffered saline, vascular endothelial growth factor ＋ neural stem cells, and neural stem cells alone were administered into the sensorimotor cortex using the stereotaxic instrument and microsyringe. After transplantation, the radial-arm water maze test and holding test were performed. Immunohistochemistry for vascular endothelial growth factor and histology using hematoxylin-eosin were performed on cerebral cortex. Results revealed that the number of vas- cular endothelial growth factor-positive cells in cerebral palsy rats transplanted with vascular endothelial growth factor-transfected neural stem cells was increased, the time for finding water and the finding repetitions were reduced, the holding time was prolonged, and the degree of cell degeneration or necrosis was reduced. These findings indicate that the transplantation of vascu- lar endothelial growth factor-transfected neural stem cells alleviates brain damage and cognitive deficits, and is neuroprotective in neonatal rats with hypoxia ischemic-mediated cerebral palsy.

Isolation,purification,structural characteristic and antioxidative property of polysaccharides from A.cepa L.var.agrogatum Don

Allium cepa L.var.agrogatum Don(ALAP)is commonly consumed in China as well as other regions and has various beneficial health effects.A novel acidic polysaccharide(named ALAP-21)was obtained from ALAP by ultrasonic and microwave-assisted extraction and purification using DEAE-52 anion exchange and Sephadex G-100 columns.The monosaccharide composition,structural and antioxidative properties of ALAP-21 were investigated by GC–MS chromatography,FT-IR and NMR spectroscopies and three antioxidative activity tests in vitro.The results showed that ALAP-21 was a heteropolysaccharide composed of glucose,galacturonic acid,mannose,galactose,arabinose,rhamnose,xylose,fructose and glucuronic acid with a relative molar ratio of 26.282:27.546:11.400:4.781:2.467:2.445:3.622:1.106:1.753,owning(1→4)-β-d-Glcp,(1→4)-β-d-GalAp6Me3OA,(1→4)-β-d-Galp6OMe,(1→2)-β-l-Rhap,(1→4)-β-d-Manp glycosidic linkages.(1→4)-β-d-Glcp and(1→4)-β-d-GalAp6Me3OA residues might be the main components of the sugar chain backbone of ALAP-21.Furthermore,ALAP-21 exhibited high potential for DPPH radicals(82.02%),hydroxyl radicals(53.33%)and superoxide anion radicals(50.28%).These results provide a reference for further research and rational development of ALAP polysaccharides.

Resting-state connectivity in the default mode network and insula during experimental low back pain

Functional magnetic resonance imaging studies have shown that the insular cortex has a signif- icant role in pain identification and information integration, while the default mode network is associated with cognitive and memory-related aspects of pain perception. However, changes in the functional connectivity between the defauk mode network and insula during pain remain unclear. This study used 3.0 T functional magnetic resonance imaging scans in 12 healthy sub- jects aged 24.8 ± 3.3 years to compare the differences in the functional activity and connectivity of the insula and default mode network between the baseline and pain condition induced by intramuscular injection of hypertonic saline. Compared with the baseline, the insula was more functionally connected with the medial prefrontal and lateral temporal cortices, whereas there was lower connectivity with the posterior cingulate cortex, precuneus and inferior parietal lobule in the pain condition. In addition, compared with baseline, the anterior cingulate cortex exhibited greater connectivity with the posterior insula, but lower connectivity with the anterior insula, during the pain condition. These data indicate that experimental low back pain led to dysfunction in the connectivity between the insula and default mode network resulting from an impairment of the regions of the brain related to cognition and emotion, suggesting the impor- tance of the interaction between these regions in pain processing.

A fiber Bragg grating based earth and water pressures transducer with three-dimensional fused deposition modeling for soil mass

A novel fiber Bragg grating(FBG)sensor with three-dimensional(3D)fused deposition modeling(FDM)approach is proposed for effective stress measurement in soil mass.The three-diaphragm structure design is developed to measure earth and water pressures simultaneously.The proposed transducer has advantages of small size,high sensitivity,low cost,immunity to electromagnetic interference and rapid prototyping.The working principle,design parameters,and manufacturing details are discussed.The proposed transducer was calibrated for earth and water pressures measurement by using weights and a specially designed pressure chamber,respectively.The calibration results showed that the wavelength of the transducer was proportional to the applied pressure.The sensitivity coefficients of the earth and water pressures were 12.633 nm/MPa and 6.282 nm/MPa,respectively.Repeated tests and error analysis demonstrated the excellent stability and accuracy of the earth and water pressure measurements.The performance of the proposed transducer was further verified by a model experimental test and numerical analysis,which indicated that the proposed transducer has great potential for practical applications.

An improved bearing fault detection strategy based on artificial bee colony algorithm

The operating state of bearing affects the performance of rotating machinery;thus,how to accurately extract features from the original vibration signals and recognise the faulty parts as early as possible is very critical.In this study,the one‐dimensional ternary model which has been proved to be an effective statistical method in feature selection is introduced and shapelet transformation is proposed to calculate the parameter of one‐dimensional ternary model that is usually selected by trial and error.Then XGBoost is used to recognise the faults from the obtained features,and artificial bee colony algorithm(ABC)is introduced to optimise the parameters of XGBoost.Moreover,for improving the performance of intelligent algorithm,an improved strategy where the evolution is guided by the probability that the optimal solution appears in certain solution space is proposed.The experimental results based on the failure vibration signal samples show that the average accuracy of fault signal recognition can reach 97%,which is much higher than the ones corresponding to traditional extraction strategies.And with the help of improved ABC algorithm,the performance of XGBoost classifier could be optimised;the accuracy could be improved from 97.02%to 98.60%compared with the traditional classification strategy.

A survey on hearing acuity of centenarians in Hainan Province

Objective: This study aimed to investigate hearing acuity of centenarians in Hainan Province and provide basis for interventional considerations.Method: Door-to-door follow-up was conducted to investigate hearing acuity of centenarians(aged 100 years or above) in Hainan Province. Physical examination, pure tone audiometry and acoustic impedance test were performed, and the results were analyzed.Result: A total of 460 centenarians(920 ears) were tested by pure tone audiometry. The rate of normal hearing was 0.2%, the rate of mild hearing loss was 1.5%, 12% for moderate hearing loss, 33.9% for moderate to severe hearing loss, 37.4% for severe hearing loss is and 15% for profound hearing loss. Acoustic impedance test was performed in 340 centenarians(668 ears). Tympanogram was type A in 41.2% of the ears, type As in 34.1% ears,type Ad in 6.4%, type B in 11.8%, and type C in 4.9% of the ears, while no response was elicited in 1.5% of the ears.Conclusion: Age related sensorineural hearing loss is prevalent among centenarians in Hainan Province. A probably beneficial intervention may be the use of hearing aids for effective communication.

高效液相色谱法同时测定祛痘类化妆品中的10种抗痤疮类化学成分及质谱确证

建立了同时检测祛痘类化妆品中的10种抗痤疮类成分(过氧苯甲酰、螺内酯、他卡西醇、他扎罗汀、阿维A、异维甲酸、维甲酸、依曲替酯、维胺酯、阿达帕林)的高效液相色谱-紫外筛查、定量方法及液相色谱-质谱定性确证方法。样品经甲醇提取后,经Agilent ZORBAX Extend-C18(4.6×250 mm,5μm)色谱柱分离,以甲醇和乙酸水溶液为流动相梯度洗脱,PDA检测器多波长检测,外标法定量。结果表明,方法的回收率为80.8%~102.7%,相对标准偏差小于3.0%,10种抗痤疮类成分在各自的质量浓度范围内均呈良好的线性关系(相关系数均≥0.9998),检出限为0.1~1.0 mg/kg。该方法具有前处理步骤简单、分析时间短、准确性好等特点,适用于化妆品中祛痘类化妆品中的10种抗痤疮类成分的定性筛查及含量测定。

Usage Count： A New Indicator to Detect Research Fronts

Purpose： Research fronts build on recent work, but using times cited as a traditional indicator to detect research fronts will inevitably result in a certain time lag. This study attempts to explore the effects of usage count as a new indicator to detect research fronts in shortening the time lag of classic indicators in research fronts detection. Design/methodology/approach： An exploratory study was conducted where the new indicator ＂usage count＂ was compared to the traditional citation count, ＂times cited,＂ in detecting research fronts of the regenerative medicine domain. An initial topic search of the term ＂regenerative medicine＂ returned 10,553 records published between 2000 and 2015 in the Web of Science （WoS）. We first ranked these records with usage count and times cited, respectively, and selected the top 2,000 records for each. We then performed a co-citation analysis in order to obtain the citing papers of the co-citation clusters as the research fronts. Finally, we compared the average publication year of the citing papers as well as the mean cited year of the co-citation clusters. Findings： The citing articles detected by usage count tend to be published more recently compared with times cited within the same research front. Moreover, research fronts detected by usage count tend to be within the last two years, which presents a higher immediacy and real-time feature compared to times cited. There is approximately a three-year time span among the mean cited years （known as ＂intellectual base＂） of all clusters generated by usage count and this figure is about four years in the network of times cited. In comparison to times cited, usage count is a dynamic and instant indicator. Research limitations： We are trying to find the cutting-edge research fronts, but those generated based on co-citations may refer to the hot research fronts. The usage count of older highly cited papers was not taken into consideration, because the usage count indicator released by WoS only reflects usage logs after February 2013. Practical implications： The article provides a new perspective on using usage count as a new indicator to detect research fronts.Originality/value： Usage count can greatly shorten the time lag in research fronts detection, which would be a promising complementary indicator in detection of the latest research fronts.

UPLC-ESI-Q-TOF/MS法测定化妆品中倍他米松及其8种类似物

建立了同时分析倍他米松及其8种类似物的超高效液相色谱-高分辨质谱联用仪(UPLC-ESI-Q-TOF/MS)的定性、定量检测方法。采用小颗粒色谱柱,梯度洗脱,电喷雾离子源正离子模式(ESI+),利用TOF采集的化合物母离子推测分子组成,子离子推测结构,并借助对照品加以确证,利用质谱一级准分子离子建立含量测定方法。对建立的检测方法进行方法学验证,发现考察范围内线性关系良好,检出浓度为0.05~0.34 mg/kg,回收率为93.1%~103.7%,相对标准偏差普遍小于6%。在对10批化妆品的分析中,有5批检出激素,并首次发现了2种新的激素添加物:倍他米松17-丙酸酯、倍他米松21-丙酸酯。

Weighted Lipschitz Estimate for Commutator of Bochner-Riesz Operators on Weighted Morrey Spaces

In this paper, we will use a method of sharp maximal function approach to show the boundedness of commutator [b,TR^δ] by Bochner-Riesz operators and the function b on weighted Morrey spaces L^p,k （ω） under appropriate conditions on the weight w, where b belongs to Lipschitz space or weighted Lipschitz space.

One Stage Reconstruction of Esophageal Atresia and Distal Tracheoesophageal Fistula in a 3250-gm Neonate: A Case Report

Esophageal atresia (EA) occurs when the upper part of the esophagus does not connect with the lower part of esophagus and stomach. Tracheoesophageal fistula (TEF) is an abnormal connection between the upper part of the esophagus and the trachea. Treatment for esophageal atresia has advanced over several decades due to improvements in surgical techniques and neonatal intensive care. The aim is to share our experience regarding the treatment of esophageal atresia with tracheoesophageal fistula. A 4-day-old neonate suffering from esophageal atresia with type IIIB tracheoesophageal fistula underwent one stage esophageal reconstruction and obtained good outcome without any complications. In this paper, a simple intra-operative technique for tracheal fistula repair and end to end esophageal anastomosis is discussed. We used a simple technique that we have found useful for ligation of tracheal fistula. Anastomosis of lower and upper esophagus without any complication like anastomotic leakage or stricture/stenosis of the neonate with EA/TEF (type IIIB), was proved to be safe and effective.

Research on Assembly and catalysis of Transition Metal Organic Complexes

We designed and synthesized ligand L1 with C3 synametry in the paper, through self-assembly with silver nitrate obtained complexes 1 of silver double helix with three nuclear, that were used to characterize its structure by NMR and mass spectrometry, the complex silver as the catalytic sites, and the ligand L of hydrogen on the nitrogen fell microphone has certain basic, that can be used as an auxiliary Methylene dehydrogenation of Isopropyl methyl cyanoacetate, thereby accelerating the reaction. Further, the introduction of a chiral ligand to give complexes 2, to achieve an asymmetric aldol reaction of methyl isocyanoacetate.

Role of adhesion molecules in cancer and targeted therapy

Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them.Various mechanisms deregulate adhesion molecules in cancer,enabling tumor cells to proliferate without restraint,invade through tissue boundaries,escape from immune surveillance,and survive in the tumor microenvironment.Recent studies have revealed that adhesion molecules also drive angiogenesis,reshape metabolism,and are involved in stem cell self-renewal.In this review,we summarize the functions and mechanisms of adhesion molecules in cancer and the tumor microenvironment,as well as the therapeutic strategies targeting adhesion molecules.These studies have implications for furthering our understanding of adhesion molecules in cancer and providing a paradigm for exploring novel therapeutic approaches.

Recentprogress in thebiomedical application of PEDOT:PSS hydrogels

Bioelectronics have gained substantial research attention owing to their potential applications in health monitoring and diagnose,and greatly promoted the development of biomedicine.Recently,poly(3,4-ethylenedioxythiophene):polystyrene sulfonate(PEDOT:PSS)hydrogels have arose as a promising candi-date for the next-generation bioelectronic interface due to its high-conductivity,versatility,flexibility and biocompatibility.In this review,we highlight the recent advances of PEDOT:PSS hydrogels,including the gelation methods and modification strategies,and summarize their wide applications in different type of sensors and tissue engineering in detail.We expect that this work will provide valuable information regarding the functionalizations and applications of PEDOT:PSS hydrogels.