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淋巴结转移率与Ⅲa-N2非小细胞肺癌临床特征和生存相关性研究 被引量:17
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作者 张善渊 王亮 +2 位作者 鲁方亮 裴宇权 杨跃 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第11期702-708,共7页
背景与目的淋巴结解剖位置是非小细胞肺癌N分期的基础,但Ⅲa-N2非小细胞肺癌生存差异显著,淋巴结转移率或与非小细胞肺癌预后有关,或可成为Ⅲa-N2非小细胞肺癌亚组评估指标。本研究探究淋巴结转移率与Ⅲa-N2非小细胞肺癌临床病理特征和... 背景与目的淋巴结解剖位置是非小细胞肺癌N分期的基础,但Ⅲa-N2非小细胞肺癌生存差异显著,淋巴结转移率或与非小细胞肺癌预后有关,或可成为Ⅲa-N2非小细胞肺癌亚组评估指标。本研究探究淋巴结转移率与Ⅲa-N2非小细胞肺癌临床病理特征和生存的相关性。方法纳入北京大学肿瘤医院胸外二科2006年1月-2016年12月期间直接手术的288例Ⅲa-N2非小细胞肺癌患者,卡方检验分析淋巴结转移率与临床病理特征相关性,Cox回归模型分析生存危险因素,Kaplan-Meier方法绘制生存曲线。结果低淋巴结转移率139例,高淋巴结转移率149例,淋巴结转移率与腺癌(χ^2=5.924,P=0.015)、最高组N2淋巴结转移(χ^2=46.136,P<0.001)、多个N2淋巴结转移(χ^2=59.347,P<0.001)、多站N2淋巴结转移(χ^2=77.387,P<0.001)及跳跃性N2淋巴结转移(χ^2=61.524,P<0.001)显著相关,与淋巴结清扫总数无关(χ^2=0.537,P=0.464)。Cox回归模型多因素分析显示,腺癌(P=0.008)、多站N2淋巴结转移(P=0.025)和淋巴结转移率(P=0.001)是IIIa-N2非小细胞肺癌无病生存的独立危险因素,高淋巴结转移率组5年无病生存率为18.1%,低淋巴结转移率组5年无病生存率为44.1%。淋巴结转移率(P<0.001)是Ⅲa-N2非小细胞肺癌总生存的独立危险因素,高淋巴结转移率组5年总体生存率为36.7%,低淋巴结转移率组5年总体生存率为64.1%。结论淋巴结转移率与病理类型、跳跃性N2淋巴结转移、纵隔淋巴结转移个数、纵隔淋巴结转移站数、最高组N2淋巴结转移密切相关。淋巴结转移率是Ⅲa-N2非小细胞肺癌生存的独立危险因素,可更有效地预测Ⅲa-N2非小细胞肺癌亚组间的生存差异。 展开更多
关键词 肺肿瘤 IIIa-N2 淋巴结转移率 生存
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DENTING AND FAILURE OF LIQUID-FILLED TUBES UNDER LATERAL IMPACT 被引量:3
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作者 Guoyun Lu Jianping Lei +2 位作者 Zhijun Han Zhifang Liu shanyuan zhang 《Acta Mechanica Solida Sinica》 SCIE EI 2012年第6期609-615,共7页
In this paper, numerical simulation of impact cases of liquid-filled tube impacted by missiles is conducted with a commercial finite element code LS-DYNA, and the results obtained are compared with the experimental da... In this paper, numerical simulation of impact cases of liquid-filled tube impacted by missiles is conducted with a commercial finite element code LS-DYNA, and the results obtained are compared with the experimental data to verify the validity of the numerical simulation model adopted. With the verified numerical method, the processes of dynamic response of a blunt indenter impacting an empty or liquid-filled three-span continuous tubular beam are studied when the parameter such ms the indenter's mass, liquid's density or impact velocity is varied and the other conditions are kept the same. The simulation results indicate that the criticM perforation energy and the deformation of the wall of the pipe are significantly influenced by the presence of the liquid and the pressure. The liquid filling the tube provides a 'foundation' pressure to resist and localize the deformation, which may affect the perforation process and lead to a reduction of the ballistic limit. The simulation results also indicate that the increase of the fluid density filled in the tube will decrease the ballistic limit, but the fluid density must be in some scope. The relationship between the ballistic limit velocity of the tube and the mass of the impact missile is nonlinear in the Cartesian coordinate while it becomes linear through logarithmic transformation. 展开更多
关键词 impact PERFORATION fluid-structure interaction TUBE
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