The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycolipid(TH-GL)on indomethacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulce...The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycolipid(TH-GL)on indomethacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulcer model was established by oral administration of 30mgkg^(-1) IDM after 7 days of TH-GL or omeprazole(OME)administration in rats.Then the macroscopic gastric injury symptoms,gastric mucosa protective factor cyclooxygenase 1(COX-1),cyclooxygenase 2(COX-2),prostaglandin E_(2)(PGE_(2)),the levels of oxidative stress,and inflammatory cytokine expression levels in the rats were analyzed.The experimental results showed that multiple ulcers appeared on the gastric surface of the rats in the model group.Compared to the model group,TH-GL significantly alleviated gastric ulcers and reduced the gastric damage index in rats.In addition,TH-GL significantly promoted the expression of constitutive enzyme COX-1 while inhibited the expression of inducible enzyme COX-2,and make PGE2 maintain at normal levels.TH-GL also inhibited oxidative stress and inflammatory responses,increased superoxide dismutase(SOD)activity and glutathione(GSH)content,decreased the level of malondialdehyde(MDA)and the content of pro-inflammatory factor.In conclusion,these results suggested that TH-GL could maintain the expression levels of COX-1 and PGE2 while inhibit the expression of COX-2 in the gastric of rat and then prevent IDM-induced gastric ulcer,which may be related to the regulation of oxidative stress and inflammatory response.Therefore,TH-GL might be a new option for the prevention of gastric diseases induced by IDM.展开更多
目的:研究点阵CO_(2)激光联合吡美莫司乳膏外用治疗白癜风的临床效果。方法:选取2019年10月-2021年10月笔者医院门诊收治的90例白癜风患者作为研究对象,随机均分为观察组(点阵CO_(2)激光联合吡美莫司乳膏外用治疗)和对照组(吡美莫司乳...目的:研究点阵CO_(2)激光联合吡美莫司乳膏外用治疗白癜风的临床效果。方法:选取2019年10月-2021年10月笔者医院门诊收治的90例白癜风患者作为研究对象,随机均分为观察组(点阵CO_(2)激光联合吡美莫司乳膏外用治疗)和对照组(吡美莫司乳膏外用治疗),各45例。比较两组治疗6个月后疗效、病情改善情况[复色时间、白癜风面积评分指数(Vitiligo area scoring index,VASI)],治疗前及治疗6个月后疾病相关因子(CD4^(+)、CD8^(+)),及两组用药期间不良反应发生情况。结果:治疗6个月后,观察组治疗有效率明显高于对照组(P<0.05);观察组复色时间、VASI水平均明显低于对照组(P<0.05);治疗6个月后,观察组CD4^(+)水平均明显高于治疗前及同期对照组,CD8^(+)水平均明显低于治疗前及同期对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论:点阵CO_(2)激光联合吡美莫司乳膏外用治疗白癜风疗效显著,能够促进白癜风皮损恢复,改善机体免疫功能。展开更多
The dynamic response performance of a large,cylindrical,fluid-filled steel container under high-speed impact is evaluated through fluid-structure interaction analysis using arbitrary Lagrange-Eulerian(ALE)method.The A...The dynamic response performance of a large,cylindrical,fluid-filled steel container under high-speed impact is evaluated through fluid-structure interaction analysis using arbitrary Lagrange-Eulerian(ALE)method.The ALE method is adopted to accurately calculate the structural behavior induced by the internal liquid impact of the container.The stress and strain results obtained from the finite element analysis are in line with the experimental shell impact data.The influences of drop angle,drop height,and flow impact frequency are discussed.Calculation results indicate that the impact stress and damage of the container increase with drop height.However,the amplitude of the oscillation and the impact stress increase when the container and flow impact resonance occur at a certain drop height.The impact stress shows a nonlinear relationship with drop angle.展开更多
基金supported by the National Key R&D Pro-grams of China(No.2018YFD0901103)the Hainan Provincial Natural Science Foundation of China(No.2019 RC093).
文摘The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycolipid(TH-GL)on indomethacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulcer model was established by oral administration of 30mgkg^(-1) IDM after 7 days of TH-GL or omeprazole(OME)administration in rats.Then the macroscopic gastric injury symptoms,gastric mucosa protective factor cyclooxygenase 1(COX-1),cyclooxygenase 2(COX-2),prostaglandin E_(2)(PGE_(2)),the levels of oxidative stress,and inflammatory cytokine expression levels in the rats were analyzed.The experimental results showed that multiple ulcers appeared on the gastric surface of the rats in the model group.Compared to the model group,TH-GL significantly alleviated gastric ulcers and reduced the gastric damage index in rats.In addition,TH-GL significantly promoted the expression of constitutive enzyme COX-1 while inhibited the expression of inducible enzyme COX-2,and make PGE2 maintain at normal levels.TH-GL also inhibited oxidative stress and inflammatory responses,increased superoxide dismutase(SOD)activity and glutathione(GSH)content,decreased the level of malondialdehyde(MDA)and the content of pro-inflammatory factor.In conclusion,these results suggested that TH-GL could maintain the expression levels of COX-1 and PGE2 while inhibit the expression of COX-2 in the gastric of rat and then prevent IDM-induced gastric ulcer,which may be related to the regulation of oxidative stress and inflammatory response.Therefore,TH-GL might be a new option for the prevention of gastric diseases induced by IDM.
文摘目的:研究点阵CO_(2)激光联合吡美莫司乳膏外用治疗白癜风的临床效果。方法:选取2019年10月-2021年10月笔者医院门诊收治的90例白癜风患者作为研究对象,随机均分为观察组(点阵CO_(2)激光联合吡美莫司乳膏外用治疗)和对照组(吡美莫司乳膏外用治疗),各45例。比较两组治疗6个月后疗效、病情改善情况[复色时间、白癜风面积评分指数(Vitiligo area scoring index,VASI)],治疗前及治疗6个月后疾病相关因子(CD4^(+)、CD8^(+)),及两组用药期间不良反应发生情况。结果:治疗6个月后,观察组治疗有效率明显高于对照组(P<0.05);观察组复色时间、VASI水平均明显低于对照组(P<0.05);治疗6个月后,观察组CD4^(+)水平均明显高于治疗前及同期对照组,CD8^(+)水平均明显低于治疗前及同期对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论:点阵CO_(2)激光联合吡美莫司乳膏外用治疗白癜风疗效显著,能够促进白癜风皮损恢复,改善机体免疫功能。
基金supported by the Prospective Joint Research Fund of the Jiangsu Provincial Department of Science and Technology Agency(No.BY2016073-11)
文摘The dynamic response performance of a large,cylindrical,fluid-filled steel container under high-speed impact is evaluated through fluid-structure interaction analysis using arbitrary Lagrange-Eulerian(ALE)method.The ALE method is adopted to accurately calculate the structural behavior induced by the internal liquid impact of the container.The stress and strain results obtained from the finite element analysis are in line with the experimental shell impact data.The influences of drop angle,drop height,and flow impact frequency are discussed.Calculation results indicate that the impact stress and damage of the container increase with drop height.However,the amplitude of the oscillation and the impact stress increase when the container and flow impact resonance occur at a certain drop height.The impact stress shows a nonlinear relationship with drop angle.
