Effect of glutamine nutrition support on the intestinal mucosal barrier function and inflammatory response in patients with severe acute pancreatitis

Objective:To study the effect of glutamine nutrition support on the intestinal mucosal barrier function and inflammatory response in patients with severe acute pancreatitis.Methods:Patients with severe acute pancreatitis who were treated in Pengzhou People's Hospital between May 2014 and November 2016 were selected as the research subjects and randomly divided into two groups, control group received conventional symptomatic treatment and conventional enteral nutrition intervention, and Gln group received conventional symptomatic treatment and glutamine enteral nutrition intervention. The contents of intestinal mucosal barrier damage markers and inflammatory mediators in serum as well as the expression of inflammatory signaling molecules in peripheral blood were detected before and after treatment;the number of intestinal flora was detected after treatment.Results:After treatment, LPS, DAO, HBD2, TNF-α, sTREM-1, IL-1β and IL-6 levels in serum as well as TLR4, NF-kB, MyD88 and p38MAPK mRNA expression in peripheral blood mononuclear cells of both groups of patients were significantly lower than those before treatment, LPS, DAO, HBD2, TNF-α, sTREM-1, IL-1β and IL-6 levels in serum as well as TLR4, NF-kB, MyD88 and p38MAPK mRNA expression in peripheral blood mononuclear cells of Gln group after treatment were significantly lower than those of control group, and the number of lactobacillus, bifidobacterium and bacteroides were significantly higher than those of control group while the number of escherichia coli and enterococcus were significantly lower than those of control group.Conclusion: Glutamine nutrition support for severe acute pancreatitis can reduce the intestinal mucosal barrier function injury and inhibit the inflammatory response activation.

Synthesis and study of Bi_2Ti_2O_7/TiO_2 composites as efficient visible-light-active photocatalysts in the reduction of aqueous Cr(VI)

In this work, Bi2Ti2O7/TiO2 composites were synthesized and studied as potential visible-light-activated photocatalysts in the reduction of aqueous Cr（VI）. Bi2Ti2O7/TiO2 composites with tunable compositions were synthesized via a solvothermal-calcination two-step method, simply by changing the molar ratios of Bi（NO3）3·5H2O to tetrabutyl titanate in the reactants. The compositions, structures and optical properties of the as-synthesized Bi2Ti2O7/TiO2 composites were characterized by X-ray diffraction, field emission scanning electron microscopy and UV–vis diffuse reflectance spectra. The photocatalytic activity of the as-synthesized Bi2Ti2O7/TiO2 composites was tested in the reduction of aqueous Cr（VI）under visible-light（λ420 nm） irradiation, and compared with that of TiO2 nanoparticles. It was observed that the as-synthesized Bi2Ti2O7/TiO2 composites exhibited much higher photocatalytic activity than TiO2 nanoparticles, and the most efficient composite（300 mg） can achieve the complete reduction of Cr（VI） in 300 mL of 50 mg/L K2Cr2O7 aqueous solution under visible-light（λ420 nm）irradiation in 90 min.