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Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma
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作者 Liang GE shao-feng liu 《Current Medical Science》 SCIE CAS 2022年第4期832-840,共9页
Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rare... Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rarely focused on hypopharyngeal carcinoma(HPC).In our study,the effect of FST expression on HPC tissues and cell lines was investigated.Methods:A total of 60 patients with HPC were recruited for this study.Levels of FST mRNA and protein were measured by quantitative polymerase chain reaction(PCR)and immunohistochemistry in HPC tissue samples and by qPCR in the HPC FaDu cells,as well as immortal nasopharyngeal epithelial cell line NP-69 cells.After silencing the FST expression in FaDu cells using lentivirus-mediated siRNA that was specific for FST mRNA,cell proliferation was determined by a Celigo assay.Tumor growth was monitored in nude mice and viability was determined by a methylthiazoletetrazolium assay.The ratio of cell cycle arrest and apoptosis was evaluated by flow cytometry.The colony formation ability was performed using Giemsa staining.In addition,wound healing and Transwell migration and invasion assays were performed for the analysis of cell motility.Results:FST expression was significantly higher in human HPC tissue and FaDu cells than in normal tissue and NP-69 cells.A higher expression of FST in HPC samples was positively correlated with advanced tumors.Moreover,FST knockdown by shRNA significantly decreased cell growth,colony formation,migration and invasion.Furthermore,FST silencing increased the cell apoptosis percentage,and arrested cell cycle in the S phase in FaDu cells.In addition,FST silencing suppressed tumor growth in vivo.Conclusions:Our results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC. 展开更多
关键词 FOLLISTATIN hypopharyngeal carcinoma migration INVASION PROLIFERATION apoptosis
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环硅氧烷阴离子开环均聚及共聚研究进展 被引量:6
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作者 夏爽 刘小兵 +4 位作者 赵娜 李玉全 赵祺 刘绍峰 李志波 《高分子学报》 SCIE CAS CSCD 北大核心 2018年第12期1482-1492,共11页
聚硅氧烷是一类典型的有机/无机杂化聚合物,具有耐高低温、优异的环境适应性等突出性能,在航空航天、国防科技等领域应用广泛.环硅氧烷单体阴离子开环聚合是制备不同链结构及功能化聚硅氧烷的重要途径,也是推动有机硅聚合物发展的重要... 聚硅氧烷是一类典型的有机/无机杂化聚合物,具有耐高低温、优异的环境适应性等突出性能,在航空航天、国防科技等领域应用广泛.环硅氧烷单体阴离子开环聚合是制备不同链结构及功能化聚硅氧烷的重要途径,也是推动有机硅聚合物发展的重要研究领域之一.本文以阴离子开环聚合制备聚硅氧烷所涉及的环硅氧烷单体为线索,梳理了与不同化学结构环硅氧烷单体均聚及共聚相匹配的引发体系、聚合条件,以及聚合产物状态,并对相关研究工作做了论述介绍.此外,本文基于此线索对代表性研究体系做了简明罗列,便于高效检索及整体对比认知. 展开更多
关键词 阴离子开环 环硅氧烷 聚硅氧烷 均聚 共聚
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有机催化CO_(2)/环氧/酸酐交替共聚合成聚碳酸酯/聚酯及其共聚物 被引量:2
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作者 马钰琨 刘绍峰 李志波 《高分子学报》 SCIE CAS CSCD 北大核心 2022年第9期1041-1056,共16页
发展环境友好高分子材料符合当代绿色及可持续发展的理念,同时也是解决目前环境问题的有效途径之一.二氧化碳(CO_(2))来源广泛且无毒,却是造成温室效应的主要气体.利用CO_(2)和环氧交替共聚可以制备聚碳酸酯材料,而环氧和酸酐交替共聚... 发展环境友好高分子材料符合当代绿色及可持续发展的理念,同时也是解决目前环境问题的有效途径之一.二氧化碳(CO_(2))来源广泛且无毒,却是造成温室效应的主要气体.利用CO_(2)和环氧交替共聚可以制备聚碳酸酯材料,而环氧和酸酐交替共聚则可以制备聚酯材料.聚碳酸酯/聚酯高分子材料在人们生活的诸多方面(食品包装和生物医药等)有着广泛的应用.有机催化剂作为一种新兴的“无金属”催化剂,在近20年中发展迅速且独具特色.近年来,我们课题组开发了一系列有机磷腈催化剂,其碱性和分子结构可调控,能够高效地催化各类环状单体的开环聚合,制备聚酯、聚醚、聚硅氧烷、聚碳酸酯等多种高分子材料.此外,有机磷腈催化剂与路易斯酸等相结合,能够方便地构筑组成多样化的二元有机催化体系,通过协同催化效应实现独特的催化性能.本专论主要包括CO_(2)/环氧交替共聚制备聚碳酸酯、环氧/酸酐交替共聚制备聚酯、混合单体三元共聚制备聚碳酸酯/聚酯共聚物3个部分.根据催化体系的不同,分别介绍了近年来有机催化CO_(2)/环氧/酸酐交替共聚合成聚碳酸酯/聚酯及其共聚物的研究进展,对聚合机理进行了适当的解释和讨论,并展望了该领域未来的发展,包括新型高效高选择性有机催化剂、新型单体和可持续高分子材料等方向. 展开更多
关键词 有机催化剂 开环聚合 交替共聚 聚碳酸酯 聚酯
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Characteristics of Electroencephalogram Arousals of Sleep- disordered Breathing Children at Different Sleep Stages 被引量:3
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作者 Da-Bo liu Yu-Jing Yao +5 位作者 Zhen-Yun Huano Jian-Wen Zhong Jia-Jian Xu Shu-Yao Qiu shao-feng liu Xin-Hua Yi 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第23期2876-2878,共3页
Sleep-disordered breathing (SDB) is the most common sleep- related disorder, and it can seriously affect sleep conditions, growth, and neurocognitive function. Recent research even demonstrates that hypertensive pat... Sleep-disordered breathing (SDB) is the most common sleep- related disorder, and it can seriously affect sleep conditions, growth, and neurocognitive function. Recent research even demonstrates that hypertensive patients with SDB are at an increased risk of developing resistant hypertension. 展开更多
关键词 Electroencephalogram Arousals Limb Arousal Index Primary Snoring Respiratory Arousal Index Sleep-disordered Breathing Spontaneous Arousal Index
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Bimetallic Aluminum Complexes Supported by Bis(salicylaldimine) Ligand: Synthesis, Characterization and Ring-opening Polymerization of Lactide 被引量:2
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作者 Tong Shi Quan-De Zheng +2 位作者 Wei-Wei Zuo shao-feng liu Zhi-Bo Li 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2018年第2期149-156,共8页
Two types of bifunctional bis(salicylaldimine) ligands(syn-L and anti-L) were designed and synthesized to support bimetallic aluminum complexes. Owing to the rigid anthracene skeleton, syn-L and anti-L successfull... Two types of bifunctional bis(salicylaldimine) ligands(syn-L and anti-L) were designed and synthesized to support bimetallic aluminum complexes. Owing to the rigid anthracene skeleton, syn-L and anti-L successfully locked two Al centers in close proximity(syn-Al2) and far apart(anti-Al2), respectively. The distance between two Al centers in syn-Al2 was defined by X-ray diffraction as 6.665 ?, which is far shorter than that in anti-Al2. In the presence of stoichiometrical Bn OH, syn-Al2 and anti-Al2 were both efficient for ring-opening polymerization(ROP) of rac-LA with the former being more active. In the presence of excess Bn OH, syn-Al2 showed an efficient and immortal feature, consistent with high conversions, matched Mns, narrow molecular weight distributions and end group fidelity, while anti-Al2 had a much lower activity or even became entirely inactive due to rapid decomposition, indicated by in situ ~1H-NMR experiments of Al complexes with Bn OH. 展开更多
关键词 Bimetallic catalyst Aluminum complex Ring-opening polymerization Immortal polymerization POLYESTER
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