Discovery of bauxite-type helium source rock in Jinzhong basin, central North China and its resource potential evaluation

1. Objective Among globally known industrial helium-enriched natural gas reservoirs, associated helium is dominantly crust-derived helium(4He), which is generated by the radioactive decay of uranium(U) and thorium(Th) in crustal rocks. These rocks with old ages are also defined as helium source rocks.Published accumulation models for helium have revealed that granite is the main and effective helium source rock in the crust(Li YH et al., 2018).

Military traumatic brain injury:a challenge straddling neurology and psychiatry

Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiological data, neuropathology, and the research achievements of diagnosis and treatment technology, and discussing its comorbidity and sequelae. To date, advances in neuroimaging and molecular biology have greatly boosted the studies on military traumatic brain injury(TBI). In particular, in terms of pathophysiological mechanisms, several preclinical studies have identified abnormal protein accumulation, blood–brain barrier damage, and brain metabolism abnormalities involved in the development of TBI. As an important concept in the field of psychiatry, TBI is based on organic injury, which is largely different from many other mental disorders. Therefore, military TBI is both neuropathic and psychopathic, and is an emerging challenge at the intersection of neurology and psychiatry.

Mutation analysis of FBN1 gene in two Chinese families with congenital ectopia lentis in northern China

AIM: To summarize the phenotypes and identify the underlying genetic cause of the fibrillin-1(FBN1) gene responsible for congenital ectopia lentis(EL) in two Chinese families in northern China.METHODS: A detailed family history and clinical data from all participants were collected by clinical examination. The candidate genes were captured and sequenced by targeted next-generation sequencing, and the results were confirmed by Sanger sequencing. Haplotyping was used to confirm the mutation sequence. Real-time PCR was used to determine the FBN1 messenger ribonucleic acid(m RNA) levels in patients with EL and in unaffected family members.RESULTS: The probands and other patients in the two families were affected with congenital isolated EL. A heterozygous FBN1 mutation in exon 21(c.2420_IVS20-8 del TCTGAAACAins CGAAAG) was identified in FAMILY-1. A heterozygous FBN1 mutation in exon 14(c.1633 C>T, p.R545 C) was identified in FAMILY-2. Each mutation cosegregated with the affected individuals in the family and did not exist in unaffected family members and 200 unrelated normal controls.CONCLUSION: The insertion-deletion mutation(c.2420 IVS20-8 del TCTGAAACA ins CGAAAG) in the FBN1 gene is first identified in isolated EL. The mutation(c.1633 C>T) in the FBN1 gene was a known mutation in EL patient. The variable phenotypes among the patients expand the phenotypic spectrum of EL in a different ethnic background.

Interpersonal psychotherapy-based psychological intervention for patient suffering from COVID-19:A case report

BACKGROUND Novel coronavirus disease 2019(COVID-19)was first found in Wuhan,China,and it has rapidly spread worldwide since the end of 2019.There is an urgent need to treat the physical and psychological aspects of COVID-19.Interpersonal psychotherapy(IPT)-based psychological intervention is an evidence-based therapy for depression and post-traumatic stress disorder.CASE SUMMARY This report describes a case of COVID-19 in a patient who transmitted the disease to his entire family.The patient received four sessions of IPT-based psychological intervention.We used the Hamilton Rating Scale for Depression and Patient Health Questionnaire to measure depression level,and the Hamilton Anxiety Scale and Generalized Anxiety Disorder to measure anxiety among the patients.CONCLUSION This case shows that IPT-based therapy can reduce COVID-19 patient depression and anxiety and the advantage of IPT-based therapy.

基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的改善作用

目的:探讨基于网络的整合心理干预对新冠肺炎患者抑郁焦虑症状的有效性。创新点:针对大规模公共卫生事件的患者,首次采用基于网络的整合心理干预技术开展抑郁焦虑症状的治疗。这不仅能够让隔离患者更便捷地获得心理干预,而且减少了心理医生的感染暴露机会。方法:纳入26例伴有抑郁焦虑症状的新冠肺炎患者,随机分为干预组和对照组。干预组给予基于网络的整合心理干预,患者在医生指导下,通过智能手机聆听音频材料,并接受整合心理干预,包括放松训练、正念治疗、"安全地"技术和蝴蝶拥抱法;对照组则给予支持性心理治疗。通过HAMD-17与HAMA量表评估患者的抑郁焦虑水平。我们发现在1周末及2周末干预组患者HAMD-17与HAMA减分均明显优于对照组。结论:基于网络的整合心理干预可有效改善伴有抑郁焦虑症状的新冠肺炎患者的情绪症状,且对隔离患者来说更便捷,也减少了心理医生的感染暴露机会。

对围产期新冠肺炎患者开展辩证行为治疗为基础的心理治疗:案例报告

目的:孕产妇的心理健康风险较为突出,但尚未有文献说明何种心理干预方式对患有新冠肺炎的围产期孕妇有效。本文报告了一例确诊新冠肺炎的35周2天孕妇在入住隔离病房后,使用辩证行为治疗(DBT)相关技术对其存在的抑郁和焦虑症状在围产期进行持续心理干预的案例,旨在探究以DBT为基础的短程心理治疗对围产期新冠肺炎患者的抑郁和焦虑症状的改善作用。创新点:首例对确诊新冠肺炎的孕产妇进行产前及产后心理评估及干预的案例。也是首次报道在公共卫生危机事件的个体干预中使用了DBT相关技术。方法:患者,女,30岁,孕35周+2天,干咳两天就诊,在当地医院进行新型冠状病毒核酸测验提示阳性后转入浙江大学医学院附属第一医院住院治疗。2020年2月8日行剖腹产,产后继续在隔离病房治疗。入院后精神科访谈及心理测量均提示存在抑郁和焦虑症状,于2月7日、10日、16日进行三次心理干预,主要使用DBT相关干预技术,包括放松训练、正念练习、情绪控制技巧训练、人际支持等。期间根据患者的需要及时调整干预策略。通过三次心理干预,患者的抑郁、焦虑症状得到改善,抑郁和焦虑量表评分与基线比显著下降。结论:本报告显示了对确诊新冠肺炎的隔离病房患者及时进行心理干预的必要性。心理干预能有效改善患者的抑郁、焦虑症状,减少或避免了精神类药物的使用,为新冠肺炎的临床治疗提供了支持。此报告也为以DBT为基础的心理治疗在危机干预中的应用提供了临床证据。

Association of Genetic Polymorphisms with Age at Onset in Han Chinese Patients with Bipolar Disorder

Dear Editor,Bipolar disorder (BD) is a chronic and disabling disorder characterized by manic, hypomanic, or depressive episodes, with an estimated lifetime prevalence ranging from 1% to 5%. Globally, it is a leading cause of disability and a socioeconomic burden.

Optic nerve sheath diameter measured using magnetic resonance imaging and factors that influence results in healthy Chinese adults: a cross-sectional study

To the Editor:Identifying the increase in intracranial pressure(ICP)is very important in the management of neurosurgical and neurological disorders,because raised ICP is associated with poor outcomes such as brain herniation and death.Although the intraparenchymal or intraventricular invasive methods remain the gold standard for ICP measurement,they cannot be routinely employed because of the lack of an adequate number of neurosurgeons.In addition,because of contraindications(eg,blood coagulation disorders and severe platelet disorders)and complications(eg,infection and hemorrhage),the invasive approach is not always possible.[1]Therefore,accurate non-invasive methods are needed to estimate ICP in clinical practice.A large number of studies have shown that the optic nerve sheath diameter(ONSD)is an indirect marker of ICP,and that there is a linear relationship between the two parameters.[1,2]Therefore,ONSD and its accurate measurement methods are getting more and more attention from scholars.