As a novel type of B cell that expands with increasing age,which was first observed in 2011[1,2],age-associated B cells(ABCs)are becoming a hotspot area in the field of immunology.More importantly,ABCs accumulate prog...As a novel type of B cell that expands with increasing age,which was first observed in 2011[1,2],age-associated B cells(ABCs)are becoming a hotspot area in the field of immunology.More importantly,ABCs accumulate progressively in chronic inflammatory states such as autoimmunity,chronic infection,and aging,and are closely associated with developing autoimmune diseases[3].展开更多
B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is ...B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation.展开更多
基金supported by Ministry of Science and Technology of China(2021YFC2300500,2021YFC2302403)the National Natural Science Foundation of China(32141004,81825010).
文摘As a novel type of B cell that expands with increasing age,which was first observed in 2011[1,2],age-associated B cells(ABCs)are becoming a hotspot area in the field of immunology.More importantly,ABCs accumulate progressively in chronic inflammatory states such as autoimmunity,chronic infection,and aging,and are closely associated with developing autoimmune diseases[3].
基金grants from the National Natural Science Foundation of China(81825010,81730043,81621002,31811540397 AND 81961130394)。
文摘B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation.
