Objective:To use immunochemical detection of fecal hemoglobin amount as a technical method,to perform a fecal immunochemical test(FIT)on the fecal specimens of research subjects who were going to undergo colonoscopy.T...Objective:To use immunochemical detection of fecal hemoglobin amount as a technical method,to perform a fecal immunochemical test(FIT)on the fecal specimens of research subjects who were going to undergo colonoscopy.The recorded results are compared and analyzed,and the sensitivity and specificity of the detection method in the diagnosis of colorectal cancer were evaluated.Methods:Three hundred of individuals who were going to undergo colonoscopy were tested for GFOBT and FIT in feces in advance,and 20μg/g was used as the threshold for determining positive FIT result.The results were analyzed and compared with the results of colonoscopy.Results:The sensitivity of FIT to the diagnosis of colorectal cancer was 80.95%,and the specificity was 86.54%.The positive predictive values of FIT test in colorectal cancer screening were 53.1%and 81.77%,respectively.Conclusion:FIT is more sensitive and specific for detecting colorectal cancer and adenoma.The fecal occult blood test(FOBT)is stronger,and FIT test detection is more valuable in colon cancer screening.展开更多
Silkworm pupa protein(SPP)that obtained by traditional method usually had a high fat content,which would impose restrictions on the further use of SPP.Herein,various functionalized ionic liquids(ILs)were used to extra...Silkworm pupa protein(SPP)that obtained by traditional method usually had a high fat content,which would impose restrictions on the further use of SPP.Herein,various functionalized ionic liquids(ILs)were used to extract SPP from silkworm pupae,the structure-performance relationship of ILs with their SPP separation performance were explored at the same time.The research showed that the maximum extraction yield of SPP was up to 62.6%with less than 0.5%low fat content by using 1-ethyl-3-methylimidazolium chloride([Emim]Cl),when the dissolution experiment was conducted at 90°C for 24 h with ethanol bath as the regeneration solvent.Comparing with the structure of raw material,the regenerated SPP maintained the native protein backbone.Meanwhile,all regenerated SPP showed a decreased crystallinity,which also exhibited decreased fraction of theα-helix comparing to thatβ-sheet united with coil random structures.展开更多
Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to in...Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.展开更多
基金Science and technology Projects for the Benefit of the people of the Ningxia Hui Autonomous Region(2016KJHM101)。
文摘Objective:To use immunochemical detection of fecal hemoglobin amount as a technical method,to perform a fecal immunochemical test(FIT)on the fecal specimens of research subjects who were going to undergo colonoscopy.The recorded results are compared and analyzed,and the sensitivity and specificity of the detection method in the diagnosis of colorectal cancer were evaluated.Methods:Three hundred of individuals who were going to undergo colonoscopy were tested for GFOBT and FIT in feces in advance,and 20μg/g was used as the threshold for determining positive FIT result.The results were analyzed and compared with the results of colonoscopy.Results:The sensitivity of FIT to the diagnosis of colorectal cancer was 80.95%,and the specificity was 86.54%.The positive predictive values of FIT test in colorectal cancer screening were 53.1%and 81.77%,respectively.Conclusion:FIT is more sensitive and specific for detecting colorectal cancer and adenoma.The fecal occult blood test(FOBT)is stronger,and FIT test detection is more valuable in colon cancer screening.
基金supported financially by the National Natural Science Foundation of China(Nos.81673400 and 21878292)。
文摘Silkworm pupa protein(SPP)that obtained by traditional method usually had a high fat content,which would impose restrictions on the further use of SPP.Herein,various functionalized ionic liquids(ILs)were used to extract SPP from silkworm pupae,the structure-performance relationship of ILs with their SPP separation performance were explored at the same time.The research showed that the maximum extraction yield of SPP was up to 62.6%with less than 0.5%low fat content by using 1-ethyl-3-methylimidazolium chloride([Emim]Cl),when the dissolution experiment was conducted at 90°C for 24 h with ethanol bath as the regeneration solvent.Comparing with the structure of raw material,the regenerated SPP maintained the native protein backbone.Meanwhile,all regenerated SPP showed a decreased crystallinity,which also exhibited decreased fraction of theα-helix comparing to thatβ-sheet united with coil random structures.
文摘Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.
