Current Status and Development Countermeasures of Forest Land Resources in Southern Cixi City

Based on the investigation of the status of forest land resources in the southern parts of Cixi City,the problems exiting in the development of forestry(e.g.overdevelopment of industry and decline in water conservation quality)are pointed out,and countermeasures(e.g.coordination,integration,scientific planning,strict protection,orderly development and ecological compensation)are put forward,in order to provide a reference for the sustainable development of forestry in Cixi City.

Roles of functional catechol-Omethyltransferase genotypes in Chinese patients with Parkinson’s disease

Background:Recent studies have found that the functional catechol-O-methyltransferase(COMT)gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease(PD).In this case–control study,we investigated the most common functional COMT gene haplotypes that had been shown to influence COMT enzymatic activity and the association of the single and combined COMT haplotypes with clinical symptoms and pharmacotherapy in Chinese patients with PD.Methods:One hundred forty-three patients with idiopathic PD and 157 healthy individuals were enrolled in this study.Four single nucleotide polymorphisms(SNPs)in the COMT gene(formed by SNPs)were genotyped in each participant:rs6269 A>G;rs4633 C>T;rs4818 C>G;and rs4680 G>A.Results:The frequencies of rs4633 T carriers,rs4680 A carriers and the two linked rs4633-rs4680 T/A carriers were significantly higher in the early onset PD group than in the healthy controls(all P<0.05).Homozygosity for rs4633(TT),rs4680(AA)and of the two linked rs4633-rs4680(TT/AA)was significantly more frequent in patients who exhibited the“wearing-off”phenomenon,longer disease duration,higher levodopa equivalent doses(LED)and higher Unified Parkinson’s Disease Rating Scale(UPDRS)scores(P<0.05).No significant differences were observed in the clinical features of patients who carried individual rs6269 and rs4818,the two linked rs6269-rs4818 and the four combined COMT SNPs.Conclusions:The results showed a possible association of combined functional COMT SNPs with PD risk,disease duration,the“wearing-off”phenomenon,daily LEDs and higher UPDRS scores,which may be useful in instituting individualized therapy for patients with PD.