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Deformation of the Haiyuan-Liupanshan fault zone inferred from the denser GPS observations 被引量:4
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作者 Yanchuan Li Chunyan Qu +5 位作者 Xinjian Shan Xiaogang Song Guohong Zhang Weijun Gan shaoyan wen Zhenjie Wang 《Earthquake Science》 CSCD 2015年第5期319-331,共13页
The Haiyuan-Liupanshan fault, an active tec- tonic feature at the Tibetan Plateau's northeastern bound- ary, was ruptured by two M8 earthquakes (1920 and 1927) bracketing an unbroken section (the Tianzhu seismic ... The Haiyuan-Liupanshan fault, an active tec- tonic feature at the Tibetan Plateau's northeastern bound- ary, was ruptured by two M8 earthquakes (1920 and 1927) bracketing an unbroken section (the Tianzhu seismic gap). A high seismic hazard is expected along the gap. To monitor deformation characteristics and do a seismic risk assessment, we made measurements at two newly built campaign-mode Global Positioning System (GPS) stations and 13 pre-existing stations in 2013 and 2014. Adding existing data from 1999 to 2014, we derived a new velocity field. Based on the horizontal velocity, we used three block models to invert the deformation of four crustal blocks. The results suggest non-uniform deformation in the interior of the Lanzhou block, the Ordos block and the Alaxan block, but uniform deformation in the Qilian block. Fault slip rates derived from block models show a decreasing trend from west to east, (2.0-3.2 mm/a on the Haiyuan fault to 0.9-1.5 mm/a on the Liupanshan fault). The Haiyuan fault evidences sinistral striking-slip movement, while the Liupanshan fault is primarily thrusting due to transformation of the displacement between the strike-slip and crustal shortening. The locking depth of each seg- ment along the Haiyuan fault obtained by fitting the fault parallel velocities varies drastically from west to east (21.8-7.1 km). The moment accumulation rate, calculated using the slip rate and locking depth, is positively corre- lated with the locking depth. Given the paucity of large seismic events during the previous millennium, the Tuo- laishan segment and the Maomaoshan segment have higher likelihood of nucleation for a future event. 展开更多
关键词 Haiyuan-Liupanshan fault Block strainmodel Fault deformation GPS
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高表达磷酸丝氨酸转氨酶1抑制胃癌细胞增殖的实验研究
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作者 温绍艳 蔡明志 梁寒 《中国肿瘤临床》 CAS CSCD 北大核心 2021年第23期1196-1200,共5页
目的:代谢重塑是肿瘤重要特征之一,多种关键代谢酶在肿瘤发生、发展过程中功能异常。磷酸丝氨酸转氨酶1(phosphoserine aminotransferase 1,PSAT1)催化磷酸丝氨酸生成,促进了肺腺癌、胶质瘤、乳腺癌、结肠癌等肿瘤的恶性发展。本研究分... 目的:代谢重塑是肿瘤重要特征之一,多种关键代谢酶在肿瘤发生、发展过程中功能异常。磷酸丝氨酸转氨酶1(phosphoserine aminotransferase 1,PSAT1)催化磷酸丝氨酸生成,促进了肺腺癌、胶质瘤、乳腺癌、结肠癌等肿瘤的恶性发展。本研究分析PSAT1在胃癌中的生物功能。方法:利用Kaplan-Meier plotter数据库分析PSAT1与胃癌患者预后的关系;利用RT-qPCR检测PSAT1在胃癌细胞株中的mRNA表达水平;构建PSAT1慢病毒高表达载体,在胃癌BGC823和NCI-N87细胞中高表达PSAT1;通过CCK-8、克隆形成和裸鼠皮下成瘤试验分析PSAT1对胃癌细胞增殖能力的影响。结果:Kaplan-Meier plotter数据库分析显示PSAT1高表达的胃癌患者有更好的总生存期(P=1.7e-6,HR=0.52)。在胃癌KATOⅢ、AGS、SNU16、NCI-N87、MKN45、BGC823、MGC803和SGC7901细胞中,PSAT1的表达水平低于永生化的胃上皮细胞GES1。CCK8试验结果显示PSAT1高表达后可以显著抑制胃癌BGC823(120 h,P<0.0001)和NCI-N87(96 h,P<0.0001)细胞的体外增殖能力。克隆形成试验同样证实PSAT1可以抑制胃癌BGC823(P=0.0296)和NCI-N87(P=0.0365)细胞的克隆形成能力。进一步动物实验表明PSAT1抑制了BGC823细胞在裸鼠体内的增殖(n=7,P=0.0091)。结论:PSAT1高表达提示胃癌患者有更好的预后;PSAT1在多数胃癌细胞株中的表达低于GES1细胞;PSAT1高表达可显著抑制胃癌细胞体外、体内的增殖。 展开更多
关键词 胃癌 磷酸丝氨酸转氨酶1 增殖
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