Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the ac...Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the activity of ALK-tyrosine kinase inhibitors(ALK-TKIs)against rare ALK rearrangements is variable,with limited clinical evidence.Here,we reported the case of a novel kinase D interacting substrate 220(KIDINS220)-ALK fusion that showed favorable response to alectinib.展开更多
The distributed parameterized intelligent product platform(DPIPP)contains many agents of a product minimum approximate autonomous subsystem(generalized module).These distributed agents communicate,coordinate,and coope...The distributed parameterized intelligent product platform(DPIPP)contains many agents of a product minimum approximate autonomous subsystem(generalized module).These distributed agents communicate,coordinate,and cooperate using their knowledge and skills and eventually accomplish the design for mass customization in a loosely coupled environment.In this study,a new method of isomorphism analysis on generalized modules oriented to DPIPP is proposed.First,on the basis of the bill of material partition and generalized module mining,the parameters of the main characteristics are extracted to construct the main characteristic parameter matrix.Second,similarity calculation of generalized modules is realized by improving the clustering using representatives algorithm,and isomorphism model sets are obtained.Generalized modules with a similar structure are combined to complete the isomorphism analysis.The effectiveness of the proposed method is verified by taking high-and medium-pressure valve data as an example.展开更多
基金supported by the National Natural Science Foundation of China(Grants No.81872489 and 82073369)the Natural and Science Foundation of Sichuan Province(Grant No.2022NSFSC1412)。
文摘Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the activity of ALK-tyrosine kinase inhibitors(ALK-TKIs)against rare ALK rearrangements is variable,with limited clinical evidence.Here,we reported the case of a novel kinase D interacting substrate 220(KIDINS220)-ALK fusion that showed favorable response to alectinib.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.51505343 and 51705374)the China Postdoctoral Science Foundation(Grant No.2017M622509)The authors would like to thank the editors and the reviewers for their insightful comments and helpful suggestions to improve the manuscript.
文摘The distributed parameterized intelligent product platform(DPIPP)contains many agents of a product minimum approximate autonomous subsystem(generalized module).These distributed agents communicate,coordinate,and cooperate using their knowledge and skills and eventually accomplish the design for mass customization in a loosely coupled environment.In this study,a new method of isomorphism analysis on generalized modules oriented to DPIPP is proposed.First,on the basis of the bill of material partition and generalized module mining,the parameters of the main characteristics are extracted to construct the main characteristic parameter matrix.Second,similarity calculation of generalized modules is realized by improving the clustering using representatives algorithm,and isomorphism model sets are obtained.Generalized modules with a similar structure are combined to complete the isomorphism analysis.The effectiveness of the proposed method is verified by taking high-and medium-pressure valve data as an example.
