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海军潜艇员高尿酸血症患病情况调查及危险因素分析 被引量:2
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作者 沈爱玲 崔旭阳 +2 位作者 宋娟 唐睿珂 周丽娜 《中国疗养医学》 2023年第1期92-95,共4页
目的研究海军潜艇员高尿酸血症(hyperuricemia,HUA)患病情况及相关危险因素,探讨高尿酸血症的干预措施。方法回顾性分析2018年7月至2021年12月来院疗养的959名海军潜艇员不同年份、不同生活方式、不同年龄HUA患病情况,及HUA合并其他代... 目的研究海军潜艇员高尿酸血症(hyperuricemia,HUA)患病情况及相关危险因素,探讨高尿酸血症的干预措施。方法回顾性分析2018年7月至2021年12月来院疗养的959名海军潜艇员不同年份、不同生活方式、不同年龄HUA患病情况,及HUA合并其他代谢性相关疾病患病情况。结果959名潜艇员患HUA者238名,患病率24.82%,不同年份HUA患病率比较差异有高度统计学意义(P<0.01),呈逐年上升趋势;HUA与非HUA潜艇员在生活方式上比较,吸烟、饮酒方面无差异,而喜吃肉饮食习惯上差异有高度统计学意义(P<0.01);不同年龄组HUA患病率差异具有统计学意义(P<0.05),36~40岁是高危人群;HUA与非HUA潜艇员相比较,合并脂肪肝、高三酰甘油血症、谷丙转氨酶升高、血压偏高、体质指数肥胖患病率差异具有统计学意义(P<0.05),合并高胆固醇血症、空腹血糖偏高、体质指数超重患病率差异无统计学意义(P>0.05)。结论海军潜艇员高尿酸血症患病率较高,呈逐年上升趋势,36~40岁是高危人群,喜吃肉是HUA危险因素,与其他代谢性相关疾病脂肪肝、高三酰甘油血症、谷丙转氨酶升高、血压偏高、体质指数肥胖患病率呈正相关,个体和疗养机构及原单位应从主客观两方面入手进行高尿酸血症的预防干预。 展开更多
关键词 潜艇员 高尿酸血症 代谢性相关疾病 危险因素
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Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock 被引量:7
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作者 SHANG You JIANG Yuan-xu +4 位作者 Ding Ze-jun shen ai-ling XU San-peng YUAN Shi-ying YAO Shang-long 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第19期2682-2687,共6页
Background Valproic acid (VPA) improves early survival and organ function in a highly lethal poly-trauma and hemorrhagic shock model or other severe insults. We assessed whether VPA could improve organ function in a... Background Valproic acid (VPA) improves early survival and organ function in a highly lethal poly-trauma and hemorrhagic shock model or other severe insults. We assessed whether VPA could improve organ function in a rat model of septic shock and illustrated the possible mechanisms. Methods Forty Sprague-Dawley rats were randomly assigned to four groups (n=-10): control group, VPA group, LPS group, and LPS+VPA group. Lipopolysaccharide (LPS) (10 mg/kg) was injected intravenously to replicate the experimental model of septic shock. Rats were treated with VPA (300 mg/kg, i.v.) or saline. Six hours after LPS injection, blood was sampled for gas analysis, measurement of serum alanine aminotransferase, aspartate aminotransferase, urine nitrogen, creatinine and tumor necrosis factor-alpha. Lung, liver and kidney were collected for histopathological assessment. In addition, myeloperoxidase activity and tumor necrosis factor-α in pulmonary tissue were measured. Acetylation of histone H3 in lung was also evaluated by Western blotting. Results LPS resulted in a significant decrease in PaO2, which was increased by VPA administration followed LPS injection. In addition, LPS also induced an increase in the serum levels of alanine aminotransferase, aspartate aminotransferase, urine nitrogen, creatinine, and tumor necrosis factor-alpha. However, these increases were attenuated in the LPS+VPA group. The lungs, liver and kidneys from the LPS group were significantly damaged compared with the control group. However, the damage was attenuated in the LPS+VPA group. Myeloperoxidase activity and tumor necrosis factor-alpha levels in pulmonary tissue increased significantly in the LPS group compared with the control group. These increases were significantly inhibited in the LPS+VPA group. Acetylation of histone H3 in lung tissue in the LPS group was inhibited compared with the control. However, the level of acetylation of histone H3 in the LPS+VPA group was markedly elevated in contrast to the LPS group. Conclusions Treatment with VPA can attenuate multiple organ damage caused by LPS induced septic shock. Our data also suggest that the beneficial effects are in part due to the decrease in inflammatory cytokines and restoration of normal acetylation homeostasis. 展开更多
关键词 valproic acid septic shock INFLAMMATION ACETYLATION
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