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新辅助化疗对不同分子亚型乳腺癌免疫标记表达的影响 被引量:5
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作者 沈方媛 曾斌 +1 位作者 吴慧 杨露 《暨南大学学报(自然科学与医学版)》 CAS CSCD 北大核心 2018年第3期229-235,共7页
目的:分析不同分子亚型乳腺癌患者新辅助化疗后临床病理缓解及免疫标记表达变化情况,探讨这些指标变化的临床意义及与新辅助化疗疗效的相关性.方法:收集221例接受蒽环类联合紫杉类药物新辅助化疗并成功施行手术的乳腺癌患者,通过S-P免... 目的:分析不同分子亚型乳腺癌患者新辅助化疗后临床病理缓解及免疫标记表达变化情况,探讨这些指标变化的临床意义及与新辅助化疗疗效的相关性.方法:收集221例接受蒽环类联合紫杉类药物新辅助化疗并成功施行手术的乳腺癌患者,通过S-P免疫组化检测对比新辅助化疗前后雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)及细胞增殖抗原(Ki-67)的表达情况.结果:在221例乳腺癌患者中,Luminal A型的临床有效缓解率(CR+PR)低于其他3组病例(P=0.037),三阴性(17.54%)及Her-2过表达型(25.64%)的病理完全缓解率(p CR)明显高于Luminal A型(7.14%)及Luminal B型(7.23%).新辅助化疗后不同分子亚型乳腺癌患者的ki-67的下降是有差异的(P=0.04)且Ki-67的变化与新辅助化疗的疗效相关联(CR+PR)(P=0.000),而ER、PR、Her-2受体状态的变化无统计学差异(P>0.05).结论:新辅助化疗可以明显降低Ki-67的表达且与分子分型密切相关,但对ER、PR及Her-2表达的影响甚微.Ki-67可作为新辅助化疗疗效的预测指标. 展开更多
关键词 乳腺癌 分子亚型 新辅助化疗 化疗疗效 免疫组化
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Internal Strain Measurement in 3D Braided Composites Using Co-braided Optical Fiber Sensors 被引量:3
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作者 shenfangyuan RuiHUANG YunjiangRAO 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2004年第2期199-202,共4页
3D braided composite technology has stimulated a great deal of interest in the world at large. But due to the three-dimensional nature of these kinds of composites, coupled with the shortcomings of currently-adopted e... 3D braided composite technology has stimulated a great deal of interest in the world at large. But due to the three-dimensional nature of these kinds of composites, coupled with the shortcomings of currently-adopted experimental test methods, it is difficult to measure the internal parameters of this materials, hence causes it difficult to understand the material performance. A new method is introduced herein to measure the internal strain of braided composite materials using co-braided fiber optic sensors. Two kinds of fiber optic sensors are co-braided into 3D braided composites to measure internal strain. One of these is the Fabry-Parrot (F-P) fiber optic sensor; the other is the polarimetric fiber optic sensor. Experiments are conducted to measure internal strain under tension, bending and thermal environments in the 3D carbon fiber braided composite specimens, both locally and globally. Experimental results show that multiple fiber optic sensors can be braided into the 3D braided composites to measure the internal parameters, providing a more accurate measurement method and leading to a better understanding of these materials. 展开更多
关键词 Textile composites Mechanical properties Nondestructive testing BRAIDING
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