The performances of the Prostate Cancer Prevention Trial (PCPT) risk calculator and other risk calculators for prostate cancer (PCa) prediction in Chinese populations were poorly understood. We performed this stud...The performances of the Prostate Cancer Prevention Trial (PCPT) risk calculator and other risk calculators for prostate cancer (PCa) prediction in Chinese populations were poorly understood. We performed this study to build risk calculators (Huashan risk calculators) based on Chinese population and validated the performance of prostate-specific antigen (PSA), PCPT risk calculator, and Huashan risk calculators in a validation cohort. We built Huashan risk calculators based on data from 1059 men who underwent initial prostate biopsy from January 2006 to December 2010 in a training cohort. Then, we validated the performance of PSA, PCPT risk calculator, and Huashan risk calculators in an observational validation study from January 2011 to December 2014. All necessary clinical information were collected before the biopsy. The results showed that Huashan risk calculators 1 and 2 outperformed the PCPT risk calculator for predicting PCa in both entire training cohort and stratified population (with PSA from 2.0 ng ml^-1 to 20.0 ng ml^-1). In the validation study, Huashan risk calculator 1 still outperformed the PCPT risk calculator in the entire validation cohort (0.849 vs 0.779 in area under the receiver operating characteristic curve [AUC]) and stratified population. A considerable reduction of unnecessary biopsies (approximately 30%) was also observed when the Huashan risk calculators were used. Thus, we believe that the Huashan risk calculators (especially Huashan risk calculator 1) may have added value for predicting PCa in Chinese population. However, these results still needed further evaluation in larger populations.展开更多
Formaldehyde, as one of the simplest reactive carbonyl species(RCS), is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may res...Formaldehyde, as one of the simplest reactive carbonyl species(RCS), is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms,Alzheimer's disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a noninvasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups.展开更多
Three fluorinated 1,8-napthalimides were synthesized from acenaphthene.Their structures were characterized by NMR and EI-MS analyses.The structures of compounds 1b and 1c were also confirmed by X-ray diffraction analy...Three fluorinated 1,8-napthalimides were synthesized from acenaphthene.Their structures were characterized by NMR and EI-MS analyses.The structures of compounds 1b and 1c were also confirmed by X-ray diffraction analysis,which showed that they possessed different packing models.Their optoelectronic properties were investigated.The results indicated that all of the naphthalimides possess good solubility and low LUMO energy level,which make them good solution processing candidates in n-type semiconductor.展开更多
Three switchable macrocycles based on photochromic dithienylethene were synthesized under the template of dibenzylammonium hexafluorophosphate. Their structure were well-confirmed by NMR, ESI-MS and X-ray diffraction....Three switchable macrocycles based on photochromic dithienylethene were synthesized under the template of dibenzylammonium hexafluorophosphate. Their structure were well-confirmed by NMR, ESI-MS and X-ray diffraction. Their photochromism indicated that they showed good reversibility in solution. Additionally, the theoretical calculation suggested that photoirradiation can change the cavity of macrocvcles.展开更多
Some novel cycloaddition reactions based on benzyne and olefins have been developed.These reactions were performed in the absence of a transition metal catalyst,and they displayed good yields.These cycloaddition react...Some novel cycloaddition reactions based on benzyne and olefins have been developed.These reactions were performed in the absence of a transition metal catalyst,and they displayed good yields.These cycloaddition reactions of benzyne with olefins provide effective routes for synthesizing benzocyclobutenes,biaryl compounds and 9,10-dihydrophenanthrene derivatives.展开更多
文摘The performances of the Prostate Cancer Prevention Trial (PCPT) risk calculator and other risk calculators for prostate cancer (PCa) prediction in Chinese populations were poorly understood. We performed this study to build risk calculators (Huashan risk calculators) based on Chinese population and validated the performance of prostate-specific antigen (PSA), PCPT risk calculator, and Huashan risk calculators in a validation cohort. We built Huashan risk calculators based on data from 1059 men who underwent initial prostate biopsy from January 2006 to December 2010 in a training cohort. Then, we validated the performance of PSA, PCPT risk calculator, and Huashan risk calculators in an observational validation study from January 2011 to December 2014. All necessary clinical information were collected before the biopsy. The results showed that Huashan risk calculators 1 and 2 outperformed the PCPT risk calculator for predicting PCa in both entire training cohort and stratified population (with PSA from 2.0 ng ml^-1 to 20.0 ng ml^-1). In the validation study, Huashan risk calculator 1 still outperformed the PCPT risk calculator in the entire validation cohort (0.849 vs 0.779 in area under the receiver operating characteristic curve [AUC]) and stratified population. A considerable reduction of unnecessary biopsies (approximately 30%) was also observed when the Huashan risk calculators were used. Thus, we believe that the Huashan risk calculators (especially Huashan risk calculator 1) may have added value for predicting PCa in Chinese population. However, these results still needed further evaluation in larger populations.
基金support from National Natural Science Foundation of China (Nos. 21676113, 21402057, 21472059, 81671803) Youth Chen-Guang Project of Wuhan(2016070204010098)+2 种基金 the 111 Project B17019the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhensupported by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (No. CCNU16A02004)
文摘Formaldehyde, as one of the simplest reactive carbonyl species(RCS), is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms,Alzheimer's disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a noninvasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups.
基金support from National Natural Science Foundation of China(Nos.21072070,21272088)the Program for Academic Leader in Wuhan Municipality(No. 201271130441)+1 种基金supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education,the Natural Science Foundation of Hubei Province(No.2013CFB207)Excellent doctorial dissertationcultivation grant from Central China Normal University(No. 2013YBYB60)
文摘Three fluorinated 1,8-napthalimides were synthesized from acenaphthene.Their structures were characterized by NMR and EI-MS analyses.The structures of compounds 1b and 1c were also confirmed by X-ray diffraction analysis,which showed that they possessed different packing models.Their optoelectronic properties were investigated.The results indicated that all of the naphthalimides possess good solubility and low LUMO energy level,which make them good solution processing candidates in n-type semiconductor.
基金support from the National Natural Science Foundation of China(Nos.20931006,21072070, 21072071,21272088)Program for Changjiang Scholars and Innovative Research Team in University(No.IRT0953)the Program for Academic Leader in Wuhan Municipality(No. 201271130441)
文摘Three switchable macrocycles based on photochromic dithienylethene were synthesized under the template of dibenzylammonium hexafluorophosphate. Their structure were well-confirmed by NMR, ESI-MS and X-ray diffraction. Their photochromism indicated that they showed good reversibility in solution. Additionally, the theoretical calculation suggested that photoirradiation can change the cavity of macrocvcles.
基金financial support from the National Natural Science Foundation of China(Nos.20931006,21072070, 21072071,21272088)the Program for Academic Leader in Wuhan Municipality(No.201271130441)
文摘Some novel cycloaddition reactions based on benzyne and olefins have been developed.These reactions were performed in the absence of a transition metal catalyst,and they displayed good yields.These cycloaddition reactions of benzyne with olefins provide effective routes for synthesizing benzocyclobutenes,biaryl compounds and 9,10-dihydrophenanthrene derivatives.