300 MPa grade biodegradable Zn-(0.6,0.8)Mn-(<0.1)Mg alloys with yield strengths>300 MPa and elongations>15%have been developed,which are designated as Zn06Mn006Mg(HE)and Zn08Mn005Mg(HE)in as-extruded state.Th...300 MPa grade biodegradable Zn-(0.6,0.8)Mn-(<0.1)Mg alloys with yield strengths>300 MPa and elongations>15%have been developed,which are designated as Zn06Mn006Mg(HE)and Zn08Mn005Mg(HE)in as-extruded state.They are the newest members of a small group of biodegradable Zn alloys with mechanical properties beyond the generally accepted benchmark for orthopedic implants.Immersed in simulated body fluid for 30 days,Zn06Mn006Mg(HE)and Zn08Mn005Mg(HE)exhibit corrosion rates of 38 and 53μm y^(-1),respectively.They show high antibacterial rates of 93%-97%against E.coli.In 25%-75%extracts of both the alloys,MC3T3-E1 cell viabilities for 1 day and 3 days are all over 100%,indicating complete cytocompatibility.In 100%extracts for 3 days,both alloys show non-toxicity.After a longtime room temperature storage of 72 weeks,natural embrittling alike Zn-Mg alloys does not happen.The Zn-Mn-Mg alloys still have mechanical properties exceeding the benchmark by a large margin.The in vitro study shows the newly developed BHSDLA Zn-Mn-Mg alloys are promising candidates for orthopedic implants.展开更多
Trauma kills more than four million people worldwide each year,with chest trauma accounting for 25%of these deaths.Rib fractures are the main manifestation of chest trauma.Biodegradable Zn alloys offer a new option to...Trauma kills more than four million people worldwide each year,with chest trauma accounting for 25%of these deaths.Rib fractures are the main manifestation of chest trauma.Biodegradable Zn alloys offer a new option to overcome clinical problems caused by permanent rib fracture internal fixation mate-rials,e.g.,long-term stress masking and secondary surgery.In this study,the fabrication procedure of biodegradable Zn-0.5Li alloy rib plates is successfully developed,which consists of casting,hot-warm rolling,cutting,and pressing sequentially.Biomechanical three-point bending performance of the Zn al-loy rib plates is comparable to that of commercial pure Ti rib plates,much higher than that of pure Zn rib plates.In addition,the Zn alloy exhibits the best antibacterial ability against E.coli and S.aureus among the three materials.Although the Zn alloy exhibits a weaker MC3T3 cytocompatibility than pure Ti,it is better than pure Zn.This study provides a foundation for the future development of various biodegrad-able Zn alloy rib plates.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(No.52071028)Fundamental Research Funds for the Central Universities(No.FRF-TP-19-022A3Z).
文摘300 MPa grade biodegradable Zn-(0.6,0.8)Mn-(<0.1)Mg alloys with yield strengths>300 MPa and elongations>15%have been developed,which are designated as Zn06Mn006Mg(HE)and Zn08Mn005Mg(HE)in as-extruded state.They are the newest members of a small group of biodegradable Zn alloys with mechanical properties beyond the generally accepted benchmark for orthopedic implants.Immersed in simulated body fluid for 30 days,Zn06Mn006Mg(HE)and Zn08Mn005Mg(HE)exhibit corrosion rates of 38 and 53μm y^(-1),respectively.They show high antibacterial rates of 93%-97%against E.coli.In 25%-75%extracts of both the alloys,MC3T3-E1 cell viabilities for 1 day and 3 days are all over 100%,indicating complete cytocompatibility.In 100%extracts for 3 days,both alloys show non-toxicity.After a longtime room temperature storage of 72 weeks,natural embrittling alike Zn-Mg alloys does not happen.The Zn-Mn-Mg alloys still have mechanical properties exceeding the benchmark by a large margin.The in vitro study shows the newly developed BHSDLA Zn-Mn-Mg alloys are promising candidates for orthopedic implants.
基金financially supported by the National Natural Science Foundation of China(Nos.51871020,52071028,81700799,and 82070926).
文摘Trauma kills more than four million people worldwide each year,with chest trauma accounting for 25%of these deaths.Rib fractures are the main manifestation of chest trauma.Biodegradable Zn alloys offer a new option to overcome clinical problems caused by permanent rib fracture internal fixation mate-rials,e.g.,long-term stress masking and secondary surgery.In this study,the fabrication procedure of biodegradable Zn-0.5Li alloy rib plates is successfully developed,which consists of casting,hot-warm rolling,cutting,and pressing sequentially.Biomechanical three-point bending performance of the Zn al-loy rib plates is comparable to that of commercial pure Ti rib plates,much higher than that of pure Zn rib plates.In addition,the Zn alloy exhibits the best antibacterial ability against E.coli and S.aureus among the three materials.Although the Zn alloy exhibits a weaker MC3T3 cytocompatibility than pure Ti,it is better than pure Zn.This study provides a foundation for the future development of various biodegrad-able Zn alloy rib plates.
