The application of nanotechnology significantly benefits clinical practice in cancer diagnosis, treatment, and management.Especially, nanotechnology offers a promise for the targeted delivery of drugs, genes, and prot...The application of nanotechnology significantly benefits clinical practice in cancer diagnosis, treatment, and management.Especially, nanotechnology offers a promise for the targeted delivery of drugs, genes, and proteins to tumor tissues and therefore alleviating the toxicity of anticancer agents in healthy tissues.This article reviews current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes, superparamagnetic nanoparticles, and nucleic acid-based nanoparticles [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO)] as well as nanotechnologies for combination therapeutic strategies, for example, nanotechnologies combined with multidrug-resistance modulator, ultrasound, hyperthermia, or photodynamic therapy.This review raises awareness of the advantages and challenges for the application of these therapeutic nanotechnologies, in light of some recent advances in nanotechnologic drug delivery and cancer therapy.展开更多
A new flow field mathematical model is proposed to describe accurately the flow field structure and calculate the static characteristics of the pilot stage in a deflector jet servo valve(DJSV). The flow field is divid...A new flow field mathematical model is proposed to describe accurately the flow field structure and calculate the static characteristics of the pilot stage in a deflector jet servo valve(DJSV). The flow field is divided into five regions, a 3D turbulent jet is adopted to describe the free jet region, and a velocity distribution expression of the jet is proposed. The jet entrainment model is put forward in the pressure recovery region to describe the coupling relationship between the pressure in the receiving chamber and the jet flow. The static characteristics, including pressure-flow characteristics, pressure characteristics,and flow characteristics of the pilot stage are obtained. The flow field structure and the static characteristics are verified by finite element analysis(FEA) and experiment, respectively, and the mathematical model results are in good agreement with the experimental and simulation results.展开更多
基金National Natural Science Foundation of China (No.30811120440)Shanghai Science and Technology Committee (No.08410701800)
文摘The application of nanotechnology significantly benefits clinical practice in cancer diagnosis, treatment, and management.Especially, nanotechnology offers a promise for the targeted delivery of drugs, genes, and proteins to tumor tissues and therefore alleviating the toxicity of anticancer agents in healthy tissues.This article reviews current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes, superparamagnetic nanoparticles, and nucleic acid-based nanoparticles [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO)] as well as nanotechnologies for combination therapeutic strategies, for example, nanotechnologies combined with multidrug-resistance modulator, ultrasound, hyperthermia, or photodynamic therapy.This review raises awareness of the advantages and challenges for the application of these therapeutic nanotechnologies, in light of some recent advances in nanotechnologic drug delivery and cancer therapy.
基金supported by the National Natural Science Foundation of China (Nos. 51775383 and 52175059)。
文摘A new flow field mathematical model is proposed to describe accurately the flow field structure and calculate the static characteristics of the pilot stage in a deflector jet servo valve(DJSV). The flow field is divided into five regions, a 3D turbulent jet is adopted to describe the free jet region, and a velocity distribution expression of the jet is proposed. The jet entrainment model is put forward in the pressure recovery region to describe the coupling relationship between the pressure in the receiving chamber and the jet flow. The static characteristics, including pressure-flow characteristics, pressure characteristics,and flow characteristics of the pilot stage are obtained. The flow field structure and the static characteristics are verified by finite element analysis(FEA) and experiment, respectively, and the mathematical model results are in good agreement with the experimental and simulation results.
