Synthesis,O_2-binding ability and catalytic oxidation performance of cobalt(Ⅱ) complexes with dihydroxamic acid functionalized N-pivot lariat ethers

Novel Co（Ⅱ） complexes with dihydroxamic acids functionalized N-pivot lariat ether CoL^1-CoL^4 were synthesized and characterized.Their oxygenation constants（ln K_（O2）） and thermodynamic parameters（△H°,△S°） were measured.And their catalytic performance in oxidation of p-xylene to p-toluic acid（PTA） was investigated.The enhancement of O_2-binding and catalytic oxidation activity by the oxa aza crown ether ring of the cobalt complexes were discussed.

Association between HLA-B*46:01 and cutaneous adverse drug reactions in Han Chinese

The majority of patients who experience cutaneous adverse drug reactions(cADRs)concurrently receive multiple medications,meaning that the causative drug remains unidentified.We explored the association between human leukocyte antigen(HLA)alleles and cADRs,regardless of the allergenic drug,to investigate whether different drug-induced cADRs were associated with the same or similar risk alleles in a Han Chinese population.We genotyped a sample of 146 cADR patients and 230 population controls from the same hospital and systematically analyzed the association between HLA Class I genes and cADRs.The carrier frequency of HLAB∗46:01 in cADR patients was found to be significantly higher than that in population controls(P=.0021,odds ratio[OR]=2.18,95%confidence interval[CI]:1.33-2.58).Subgroup analysis showed that HLA-B∗46:01 was significantly associated with urticaria and erythema multiforme(P=.0077,OR=2.53,95%CI:1.30-4.91;and P=.0049,OR=2.77,95%CI:1.39-5.50,respectively).Furthermore,a significant association was also detected between HLA-A∗02:01 and erythema multiforme(P=.0038,OR=2.65,95%CI:1.31-5.33).This study is the first to demonstrate that HLA-B∗46:01 is a risk allele for cADRs in a Han Chinese population,indicating that screening for HLA-B∗46:01 prior to the administration of medication may predict the risk of developing cADRs.