Evodiamine and its derivatives have an asymmetric center at the C13 b position.Herein,isomers of evodiamine derivatives 2 and 3 were obtained by straightforward asymmetric total synthesis.Their inhibitory activities t...Evodiamine and its derivatives have an asymmetric center at the C13 b position.Herein,isomers of evodiamine derivatives 2 and 3 were obtained by straightforward asymmetric total synthesis.Their inhibitory activities toward topoisomerases Ⅰ and Ⅱ and their cytotoxicities in cancer cell lines were evaluated.All the four isomers exhibited good to excellent antitumor potency and the（S）-isomers were generally more active than the（R）-isomers.The binding modes of（S）-2 with topoisomerases Ⅰ and Ⅱ were also clarified by molecular docking.展开更多
This paper presents a novel method for assisting surgeons in automatically computing an optimal surgical plan by directly specifying the desired correction to a facial outline. First, the desired facial appearance is ...This paper presents a novel method for assisting surgeons in automatically computing an optimal surgical plan by directly specifying the desired correction to a facial outline. First, the desired facial appearance is designed using a 3D sculpturing tool, while the cut regions of the skull are defined based on facial anatomy. Then, the deformation of the face meshes is performed using an improved biomechanical model in which virtual external forces are driven by the displacements corresponding to the differences of node coordinates between the original and specified face meshes, and free nodes and fixed nodes are defined in terms of the contact surfaces between the soft tissues and the bones within the cut regions. Finally, the shape of the contact surfaces is updated following the deformation of the soft tissues. After registering the deformable contact surfaces and the cut surfaces, the final positions of the cut bones are estimated. Evaluation of preliminary experimental results quantitatively shows the effectiveness of the proposed approach.展开更多
基金supported by National Natural Science Foundation of China (Nos.81222044,81373278)Key Project of Science and Technology of Shanghai (Nos.11431920402,14YF1405400)
文摘Evodiamine and its derivatives have an asymmetric center at the C13 b position.Herein,isomers of evodiamine derivatives 2 and 3 were obtained by straightforward asymmetric total synthesis.Their inhibitory activities toward topoisomerases Ⅰ and Ⅱ and their cytotoxicities in cancer cell lines were evaluated.All the four isomers exhibited good to excellent antitumor potency and the（S）-isomers were generally more active than the（R）-isomers.The binding modes of（S）-2 with topoisomerases Ⅰ and Ⅱ were also clarified by molecular docking.
基金supported by the Academic Discipline Project(No.S30602)the Shanghai Science Foundation of China(No.08ZR1409300)
文摘This paper presents a novel method for assisting surgeons in automatically computing an optimal surgical plan by directly specifying the desired correction to a facial outline. First, the desired facial appearance is designed using a 3D sculpturing tool, while the cut regions of the skull are defined based on facial anatomy. Then, the deformation of the face meshes is performed using an improved biomechanical model in which virtual external forces are driven by the displacements corresponding to the differences of node coordinates between the original and specified face meshes, and free nodes and fixed nodes are defined in terms of the contact surfaces between the soft tissues and the bones within the cut regions. Finally, the shape of the contact surfaces is updated following the deformation of the soft tissues. After registering the deformable contact surfaces and the cut surfaces, the final positions of the cut bones are estimated. Evaluation of preliminary experimental results quantitatively shows the effectiveness of the proposed approach.
